Results 141 to 150 of about 49,324 (252)

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1405-1421, December 2025.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Immunogenicity assessment of concizumab in patients with Hemophilia A and b: Assays developed to measure anti-drug antibodies and integrated results from clinical trials [PDF]

Luis Perez Tosar
openalex   +1 more source

FIGO good practice recommendations: Assisted vaginal birth and the second stage of labor

International Journal of Gynecology &Obstetrics, Volume 171, Issue 3, Page 970-982, December 2025.
Abstract Cesarean birth (CB) rates are increasing globally, with a current prevalence of 21.1% and a projected prevalence of 28.5% by 2030. Conversely, assisted vaginal birth (AVB) rates are declining, with reported rates of less than 10% in low‐ and middle‐income countries (LMICs) and 10%–15% in high‐income countries (HICs). In some African countries,
Akaninyene E. Ubom, Eytan R. Barnea, Nicoletta DiSimone, Martin Mueller, Jolly Beyeza‐Kashesya, Ines Nunes, Albaro J. Nieto‐Calvache, Elif G. Topcu, Zechariah J. Malel, Bo Jacobsson, Alison Wright, the FIGO Childbirth and Postpartum Hemorrhage Committee   +11 more
wiley   +1 more source

Acquired Haemophilia Occurring in Association With Bullous Pemphigoid

JEADV Clinical Practice, Volume 4, Issue 5, Page 1196-1201, December 2025.
Capsule summary This case series of seven elderly patients describes the rare association between bullous pemphigoid (BP) and acquired haemophilia A (AHA). AHA typically developed within six months of BP onset, often coinciding with disease flares, and presented with distinctive bleeding manifestations such as haemorrhagic bullae and gastrointestinal ...
Wen Yang Benjamin Ho, Zi Teng Chai, Haur Yueh Lee, Yen Loo Lim   +3 more
wiley   +1 more source

Molecular diagnosis of hemophilia A and B. Report of five families from Costa Rica

Revista de Biología Tropical, 2004
Hemophilia Aand B are X-chromosome linked bleeding disorders caused by deficiency of the respective coagulation factor VIII and IX. Affected individuals develop a variable phenotype of hemorrhage caused by a broad range of mutations within the Factor ...
Lizbeth Salazar-Sánchez, Guillermo Jiménez-Cruz, Pilar Chaverri, Winnie Schröder, Karin Wulff, Gerardo Jiménez-Arce, Miriam Sandoval, Patricia Ramírez, F.H Herrmann   +8 more
doaj  

PB0165 Gene Correction of Human Hemophilia B Mutation by PAM-Flexible Cas9-Mediated Base-Editing Approach

, 2023
Takafumi Hiramoto, Yuji Kashiwakura, Morisada Hayakawa, Nemekhbayar Baatartsogt, N Kamoshita, Tomoyuki Abe, Hiroaki Inaba, Hiroshi Nishimasu, Hideki Uosaki, Yutaka Hanazono, Osamu Nureki, Tsukasa Ohmori   +11 more
openalex   +1 more source

Optimising outcomes in lateral unicompartmental knee arthroplasty: Analysing 25 years of registry data

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 33, Issue 12, Page 4324-4334, December 2025.
Abstract Purpose Limited data and experience surround lateral unicompartmental knee arthroplasty (UKA), contributing to uncertainty regarding its broader application in clinical practice. To understand how to optimise lateral UKA outcomes, this study aimed to evaluate the implant survival of lateral UKA and compare it to total knee arthroplasty (TKA ...
Kristine Ifigenia Bunyoz, Martin Lindberg‐Larsen, Kirill Gromov, Anders Troelsen   +3 more
wiley   +1 more source

Impact of Anticoagulation Therapy on Healthcare Utilization in Patients With Epistaxis

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 6, December 2025.
ABSTRACT Objective Epistaxis can occur in individuals on anticoagulants, raising concerns about the potential impact on healthcare utilization. This retrospective analysis aims to compare measures of healthcare utilization of two cohorts: adult epistaxis patients without anticoagulant use compared to adult epistaxis patients on anticoagulants.
Boston Andersen, Alec Kadrie, Meghana Chanamolu, M. Boyd Gillespie   +3 more
wiley   +1 more source

Evaluating the Safety and Efficacy of Concizumab in Hemophilia A/B Patients: A Systematic Review

Clinical and Applied Thrombosis/Hemostasis
Background Hemophilia A and B are X-linked recessive bleeding disorders caused by deficiencies of coagulation factors VIII and IX, respectively. These conditions lead to spontaneous bleeding, joint damage, inhibitor development, and the burden of ...
Erum Siddiqui MBBS, Maliha Khalid MBBS, Muhammad Saad Khan MBBS, Kanza Farhan MBBS, Muhammad Mohsin Khan MBBS, Aminath Waafira MBBS   +5 more
doaj   +1 more source

Cell and Gene Therapy: Transforming Treatment Paradigms for Patient‐Centric Care

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT Cell and gene therapies (CGTs) are transforming medicine by offering potential cures for diseases previously considered untreatable. Despite rapid advancements, challenges remain in optimizing efficacy and safety and ensuring patient accessibility and preference due to high costs and clinical uncertainties, particularly for rare diseases and ...
Sojeong Yi, Chia‐Yung Wu, Avery McIntosh, Maria E. Santaella, Tara M. Robinson, Michael Z. Liao   +5 more
wiley   +1 more source