Results 141 to 150 of about 13,000,271 (286)

Spontaneous urinary bladder rupture in a dog with lymphoplasmacytic cystitis

open access: yesJournal of Small Animal Practice, EarlyView.
A 10‐year‐old male mixed‐breed dog presented with vomiting and anuria. The dog was living indoors, and no trauma was reported by the owner. Ultrasonography and a retrograde urethrogram revealed the presence of a urinary bladder leakage. A celiotomy was performed to repair a urinary bladder tear, along with a biopsy of the urinary bladder wall ...
C. Donà   +6 more
wiley   +1 more source

Evaluating the Safety and Efficacy of Concizumab in Hemophilia A/B Patients: A Systematic Review

open access: yesClinical and Applied Thrombosis/Hemostasis
Background Hemophilia A and B are X-linked recessive bleeding disorders caused by deficiencies of coagulation factors VIII and IX, respectively. These conditions lead to spontaneous bleeding, joint damage, inhibitor development, and the burden of ...
Erum Siddiqui MBBS   +5 more
doaj   +1 more source

Molecular diagnosis of hemophilia A and B. Report of five families from Costa Rica

open access: yesRevista de Biología Tropical, 2004
Hemophilia Aand B are X-chromosome linked bleeding disorders caused by deficiency of the respective coagulation factor VIII and IX. Affected individuals develop a variable phenotype of hemorrhage caused by a broad range of mutations within the Factor ...
Lizbeth Salazar-Sánchez   +8 more
doaj  

Marstacimab for the Treatment of Hemophilia A or B

open access: yesBiologics: Targets and Therapy
Hemophilia A and B, caused by deficiencies of coagulation factors VIII or IX, result in impaired thrombin generation with consequent spontaneous or trauma-related bleeding, particularly hemarthroses. Although prophylactic factor replacement therapy remains the global standard of care for hemophilia, it has significant limitations, including intravenous
openaire   +2 more sources

Understanding supply sustainability of plasma‐derived medicinal products: Drivers and consequences of shortages

open access: yesVox Sanguinis, EarlyView.
Abstract Plasma‐derived medicinal products (PDMPs), particularly immunoglobulins (Igs), are essential treatments for numerous diseases, often serving as the primary therapeutic option and playing a critical role in patient care. The human origin of these products, however, can lead to supply constraints due to a lack of plasma collection, market ...
Miriam Belmonte   +4 more
wiley   +1 more source

Development and Validation of a Liquid Chromatography High‐Resolution Mass Spectrometry Method for Blood Desmopressin Quantification and Its Application in Hemophilia A Patients

open access: yesRapid Communications in Mass Spectrometry, Volume 39, Issue 18, 30 September 2025.
ABSTRACT Desmopressin (DDAVP), which indirectly increases Coagulation Factor VIII concentrations in the blood, is a common treatment for bleeding disorders such as von Willebrand disease or hemophilia A. However, DDAVP exhibits significant variability in response due to interindividual differences in pharmacokinetics.
Sophie Hodin   +7 more
wiley   +1 more source

Nine independentF9 mutations in the Mexican hemophilia B population: Nonrandom recurrences of point mutation events in the human germline [PDF]

open access: gold, 2000
Ana Rebeca Jaloma‐Cruz   +9 more
openalex   +1 more source

Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B.

open access: yesMolecular Therapy, 2020
Lindsey A. George   +14 more
semanticscholar   +1 more source

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