Results 141 to 150 of about 13,086,034 (342)

Treatment of hemophilia B: focus on recombinant factor IX

Biologics: Targets & Therapy, 2013
Massimo Franchini, Francesco Frattini, Silvia Crestani, Cinzia Sissa, Carlo BonfantiDepartment of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantua, ItalyAbstract: Hemophilia B is a recessive X-linked bleeding disorder characterized by ...
Franchini M, Frattini F, Crestani S, Sissa C, Bonfanti C   +4 more
doaj  

Prophylaxis in Hemophilia

Clinical and Biomedical Research, 2023
Hemophilia is an inherited X-linked coagulopathy defined by a deficiency or abnormality in the clotting function of factor VIII (Hemophilia A) or factor IX (Hemophilia B).
Júlia Plentz Portich, Dayenne Catelli, Ebellins Tabares Calvache, Cristiane Seganfredo Weber, Daniel Sander Hoffmann, Guilherme Rasia Bosi, Leo Sekine, Lucia Mariano da Rocha Silla   +7 more
doaj  

Hemophilia B in a male with a four-base insertion that arose in the germline of his mother [PDF]

, 1989
C. D. K. Bottema, Rhett P. Ketterling, H.I. Cho, Steve S. Sommer   +3 more
openalex   +1 more source

Orthopaedic Surgery Outcomes in Patients With Haemophilia A or B Treated With Extended Half‐Life Recombinant Factor VIII and IX Fc Fusion Proteins: A Multicentre Prospective Study

Haemophilia, EarlyView.
ABSTRACT Introduction Haemophilia A and B are hereditary bleeding disorders that require multidisciplinary perioperative management. Data on orthopaedic surgery outcomes with extended‐half‐life (EHL) recombinant Fc‐fusion factor VIII (rFVIIIFc) and factor IX (rFIXFc) products remain limited.
Luigi Piero Solimeno, Roberta Gualtierotti, Emanuele Guido, Jacopo Acquati Lozej, Enrica Cristini, Alessandro Ciavarella, Sara Arcudi, Christian Carulli, Lisa Pieri, Simona Maria Siboni, Flora Peyvandi   +10 more
wiley   +1 more source

A Dutch family with moderately severe hemophilia B (Factor IX_Heerde) has a missense mutation identical to that of factor lX_{London 2} [PDF]

, 1989
S R Poort, E Briët, R M Bertina, P H Reitsma   +3 more
openalex   +1 more source

Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice [PDF]

, 2006
Recombinant adenovirus (rAd)-mediated apoE gene transfer to the liver of apoE(-/-) mice is anti-atherogenic. However, first generation rAd vectors were associated with immune clearance of transduced hepatocytes, while an improved [E1(-), E3(-) polymerase(
Amalfitano, A, Dickson, G, Graham, IR, Harris, JD, Owen, JS   +4 more
core  

The UK Infected Blood Inquiry: A Personal Reflection

Haemophilia, EarlyView.
Peter R. Foster
wiley   +1 more source

F8 Variants and Inhibitor Development in a Multiethnic Cohort of Nonsevere Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Background Neutralising antibodies (inhibitors) against factor VIII can result in severe bleeding in persons with nonsevere haemophilia A (NSHA). The INSIGHT study of 1112 persons with NSHA in a predominantly White population identified 19 different F8 missense variants that were associated with inhibitor development. Objective To describe the
Ming Y. Lim, Kristy Lee, Jill M. Johnsen, Nigel S. Key   +3 more
wiley   +1 more source

A de novo intragenic deletion of the potential EGF domain of the factor IX gene in a family with severe hemophilia B [PDF]

, 1986
Michel Vidaud, Claude Chabret, C. Gazengel, L. Grunebaum, Jean‐Pierre Cazenave, M. Goossens   +5 more
openalex   +1 more source

High-levelexpression of functional recombinant human coagulation factor VII in insect cells [PDF]

: Recombinant coagulation factor VII (FVII) is used as a potential therapeutic intervention in hemophilia patients who produce antibodies against the coagulation factors.
AD Shapiro, Ali Jahanian Najafabadi, Amaneh Mohammadi Roushandeh, B Brenner, B Furie, BG Maick, CR Hay, DA Roth, DE Lynn, DR O’Reilly, G Bray, G Kemball-Cook, HJ Cha, I Nillson, KR Kim, Mahdi Edalati Fathabad, Mahdi Rouhbakhsh, Mahshid Mohammadipour, Mehryar Habibi Roudkenar, MK Miller, Mohamad Ali Shokrgozar, Mohamad Salimi, N Wajih, Nasser Masroori, R Halabian, R Toso, Raheleh Halabian, SM Ruiz, SM Wu, T Li, UK Laemmli   +30 more
core   +1 more source