Results 61 to 70 of about 13,243,158 (348)

Recurrent bleeding after rubber band ligation diagnosed as mild hemophilia B: a case report and literature review

BMC Surgery, 2022
Background Hemophilia is a recessive hemorrhagic disease relevant to X chromosome. In mild hemophilia cases, spontaneous bleeding is rare and the blood clotting function is normal, but severe bleeding may occur after trauma or surgery.
Xiaoying Jiang, Min Xu, Yaqing Ding, Yongqing Cao, Yibin Pan   +4 more
doaj   +1 more source

Association of psychological and physical health with quality of life in patients with haemophilia: a brief review [PDF]

Hemophilia is an inherited bleeding disorder that is caused by an x-linked deficiency of clotting factors VIII in hemophilia A and IX in hemophilia B.
Choudhry, Dimple, Dutta, Himanish, Jhandai, Malika, Kumar Atri, Sudhir, Sangeeta   +4 more
core   +2 more sources

Multiple Comorbid Conditions among Middle-Aged and Elderly Hemophilia Patients: Prevalence Estimates and Implications for Future Care [PDF]

, 2011
Introduction. Advances in hemophilia care and treatment have led to increases in the life expectancy among hemophiliacs. As a result, persons with hemophilia are reaching an older age and experiencing various age-related health conditions never seen ...
Brown, Deborah, Escobar, Miguel A., Khleif, Aroub A., Rodriguez, Nidra   +3 more
core   +3 more sources

A natural choice for hemophilia B [PDF]

Blood, 2015
In this issue of Blood, Crudele et al describe a novel study of adeno-associated virus (AAV) vector-mediated gene therapy that induced immune tolerance to factor IX (FIX) in a hemophilia B (HB) dog with previously formed anti-FIX inhibitor antibodies (IAs).
openaire   +3 more sources

Adeno-Associated Mediated Gene Transfer for Hemophilia B:8 Year Follow up and Impact of Removing "Empty Viral Particles" on Safety and Efficacy of Gene Transfer

Blood, 2018
Background: We have previously shown that a single intravenous administration of a self-complementary adeno-associated virus (scAAV) vector containing a codon-optimised factor IX gene, under control of a synthetic liver specific promoter and ...
A. Nathwani, U. Reiss, E. Tuddenham, P. Chowdary, J. McIntosh, A. Riddell, J. Pie, J. Mahlangu, M. Recht, Yu-min P Shen, K. Halka, M. Meagher, A. Nienhuis, A. Davidoff, S. Mangles, C. Morton, Junfang Zhou, V. Radulescu   +17 more
semanticscholar   +1 more source

Randomized trial of a DVD intervention to improve readiness to self-manage joint pain [PDF]

, 2011
Report of a randomized controlled trial of a motivational intervention to promote self-management of joint painA DVD (digital video disk) intervention to increase readiness to self-manage joint pain secondary to hemophilia was informed by a 2-phase ...
Abraham, Altman, Angst, Barlow, Barlow, Barry, Biller, Bode, Carr, Choiniere, Dijkstra, Elander, Elander, Elander, Fischer, Glenn, Habib, Hadjistavropoulos, Hays, Hays, Heapy, Jensen, Jensen, Jensen, Jensen, Kazis, Kerns, Kerns, Kerns, LeFort, Liao, Luck, McCracken, Moore, Nielsen, Prochaska, Richmond, Ruta, Szende, Turk, Turk, Von Korff, Vowles, Warsi   +43 more
core   +2 more sources

CRISPR/Cas9‐mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse [PDF]

, 2016
The X‐linked genetic bleeding disorder caused by deficiency of coagulator factor IX, hemophilia B, is a disease ideally suited for gene therapy with genome editing technology. Here, we identify a family with hemophilia B carrying a novel mutation, Y371D,
Dali Li, Honghui Han, Kewen Hu, Kung SH, Li Zeng, Lie Ma, Lijuan Wu, Liren Wang, Mingyao Liu, Ning Ma, Qi Li, Wenqing Lu, Yanhong Yu, Yanjiao Shao, Yanlin Ma, Yuanhua Huang, Yuting Chen, Yuting Guan, Zhenliang Sun   +18 more
core   +2 more sources

Endothelial cells derived from patients' induced pluripotent stem cells for sustained factor VIII delivery and the treatment of hemophilia A. [PDF]

, 2020
Hemophilia A (HA) is a bleeding disorder characterized by spontaneous and prolonged hemorrhage. The disease is caused by mutations in the coagulation factor 8 gene (F8) leading to factor VIII (FVIII) deficiency.
Agu, Emmanuel, Conroy, Kelsey, Cortez-Toledo, Elizabeth, Gao, Kewa, Hyllen, Alicia A, Nolta, Jan A, Pan, Guangjin, Rose, Melanie, Wang, Aijun, Zhou, Ping   +9 more
core   +1 more source

Blood clot inspired pore‐gradient nanofiber sponge with “outer filtration” and “inner adsorption” bifunction for rapid stop of uncontrolled hemorrhage

BMEMat, EarlyView.
In this study, by mimicking the nanofiber structure and netting blood cells function of fibrin network in blood clots, we developed a novel bioinspired quaternized chitosan nanofiber sponge with distinct blood cell filtration and blood plasma absorption bifunction for rapid hemostasis.
Fujin Zhou, Yong Yang, Yixuan Li, Ruolin Cao, Zheng Chen, Zhi Wang, Naiwen Tan, Lei Tian, Botao Song   +8 more
wiley   +1 more source

Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life

Hematology Reports
Background/Objectives: Hemophilia A is an X-linked recessive illness produced by a deficiency of coagulation factor VIII. This study aimed to evaluate serum vitamin D in hemophilic pediatric patients and its correlation with joint health and quality of ...
Aida M. S. Salem, Takwa Mohamed AbdEltwwab, Hanan Hosni Moawad, Marwa O. Elgendy, Reham S. Al-Fakharany, Ahmed Khames, Mohamed Hussein Meabed   +6 more
doaj   +1 more source