Results 61 to 70 of about 301,643 (264)

The benefits of prophylaxis in patients with hemophilia B [PDF]

open access: yesExpert Review of Hematology, 2018
Introduction: The health benefits of prophylactic dosing regimens for clotting factor therapy in patients with hemophilia include reduced joint damage and improved quality of life; as such, prophylaxis is recommended in treatment guidelines. However, many patients with hemophilia B are treated on demand, and prophylaxis has been utilized less ...
openaire   +3 more sources

Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope

open access: yesActa Crystallographica Section D, EarlyView.
The structure of the humanized Fab from murine monoclonal antibody 5E5 specific for tumor antigen Tn‐MUC1 has been determined to 1.57 Å resolution. The humanization process has imposed changes in the framework regions of the Fv which may have affected the Vh–Vl interface.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific ...
Wei Li   +7 more
wiley   +1 more source

Spectrum of hemophilia in Diyala-Iraq

open access: yesDiyala Journal of Medicine, 2019
Background: Deficiencies of coagulation factors have been recognized for centuries. The most common inherited factor deficiencies are the hemophilias, X-linked diseases caused by deficiency of factor VIII (hemophilia A) or factor IX ( hemophilia B ...
Imad Ahmed Lateef   +3 more
doaj   +2 more sources

Patient and parent preferences for characteristics of prophylactic treatment in hemophilia

open access: yesPatient Preference and Adherence, 2015
Roberto Furlan,1 Sangeeta Krishnan,2 Jeffrey Vietri3 1Advanced Methods, Kantar Health, Epsom, Surrey, UK; 2Global Health Economics and Outcomes Research, Biogen, MA, USA; 3Health Outcomes, Kantar Health, Milan, Italy Introduction: New longer-acting ...
Furlan R, Krishnan S, Vietri J
doaj  

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

open access: yesJournal of Translational Medicine, 2017
Background Adeno-associated virus (AAV) gene therapy vectors have shown the best outcomes in human clinical studies for the treatment of genetic diseases such as hemophilia.
David M. Markusic   +8 more
doaj   +1 more source

Circadian misalignment disrupts biomarkers of cardiovascular disease risk and promotes a hypercoagulable state

open access: yesEuropean Journal of Neuroscience, Volume 60, Issue 7, Page 5450-5466, October 2024.
We studied the impact of circadian misalignment on 238 plasma proteins linked to cardiovascular physiology. We identified 42 proteins with altered abundance, five proteins regulated by the circadian clock, and changes in many proteins in the coagulation pathway.
Andrew W. McHill   +3 more
wiley   +1 more source

Autologous and Heterologous Cell Therapy for Hemophilia B toward Functional Restoration of Factor IX

open access: yesCell Reports, 2018
Summary: Hemophilia B is an ideal target for gene- and cell-based therapies because of its monogenic nature and broad therapeutic index. Here, we demonstrate the use of cell therapy as a potential long-term cure for hemophilia B in our FIX-deficient ...
Suvasini Ramaswamy   +7 more
doaj  

Sharp Bounds for Neuman Means in Terms of Geometric, Arithemtic and Quadratic Means [PDF]

open access: yesarXiv, 2014
In this paper, we find the greatest values $\alpha_{1}$, $\alpha_{2}$, $\alpha_{3}$, $\alpha_{4}$, $\alpha_{5}$, $\alpha_{6}$, $\alpha_{7}$, $\alpha_{8}$ and the least values $\beta_{1}$, $\beta_{2}$, $\beta_{3}$, $\beta_{4}$, $\beta_{5}$, $\beta_{6}$, $\beta_{7}$, $\beta_{8}$ such that the double inequalities $$A^{\alpha_{1}}(a,b)G^{1-\alpha_{1}}(a,b)<
arxiv  

Contrasting Approaches in the Implementation of GRADE Methodology in Guidelines for Haemophilia and Von Willebrand Disease

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction The 2024 ISTH clinical practice guideline (CPG) for treatment of congenital haemophilia, the NBDF‐McMaster Guideline on Care Models for Haemophilia Management, and ASH ISTH NBDF WFH guidelines on the diagnosis and management of VWD all utilised GRADE methodology.
Mark W. Skinner   +59 more
wiley   +1 more source

Mild-severe hemophilia B impacts relationships of US adults and children with hemophilia B and their families: results from the B-HERO-S study

open access: yesPatient Related Outcome Measures, 2019
Susan Cutter,1 Christine Guelcher,2 Susan Hunter,3 Dawn Rotellini,4 Spencer Dunn,5 David L Cooper61Penn Comprehensive Hemophilia and Thrombosis Program, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 2Comprehensive Hemostasis and ...
Cutter S   +5 more
doaj  

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