Results 21 to 30 of about 7,615 (137)

Multiple Introductions of Rabbit Hemorrhagic Disease Virus Lagovirus europaeus/GI.2 in Africa [PDF]

Biology, 2021
Rabbit hemorrhagic disease (RHD) causes high mortality and morbidity in European rabbits (Oryctolagus cuniculus). In Africa, the presence of the causative agent, the rabbit hemorrhagic disease virus (RHDV), was first confirmed in 1992 (genotype Lagovirus europaeus/GI.1).
Faten Ben Chehida, Ana M. Lopes, João V. Côrte-Real, Soufien Sghaier, Rim Aouini, Lilia Messadi, Joana Abrantes   +6 more
openaire   +4 more sources

Ecosystem Effects of Variant Rabbit Hemorrhagic Disease Virus, Iberian Peninsula

Emerging Infectious Diseases, 2014
The Aragón monitoring scheme is run by the Fish and Game Department, Government of Aragón. M.D.M. was supported by a JAE-DOC contract (Programa Junta para la Ampliación de Estudios), funded by CSIC and the European Social Fund. C.F. was supported by a Post-Doctoral Fellowship funded by NSERC, Government of Canada. C.G.
Miguel Delibes-Mateos, Catarina Ferreira, Francisco Carro, Marco A. Escudero, Christian Gortázar   +4 more
openaire   +5 more sources

Confirmation and Phylogenetic Analysis of Rabbit Hemorrhagic Disease Virus in Free-living Rabbits from the Netherlands [PDF]

Journal of Wildlife Diseases, 2006
The number of free-living European rabbits (Oryctolagus cuniculus) in the Netherlands has declined dramatically in recent years. Although rabbit hemorrhagic disease virus (RHDV) infection has been implicated as a possible cause of this decline, the definitive diagnosis has not been reported.
G. H. van Bolhuis, F. van Zijderveld, D. van Riel, J. M. Drees, A.D.M.E. Osterhaus, Thijs Kuiken, M. W. G. van de Bildt   +6 more
openaire   +4 more sources

Macrophage tropism of rabbit hemorrhagic disease virus is associated with vascular pathology

Virus Research, 1999
To delineate the interactions between rabbit hemorrhagic disease virus (RHDV) and host cells, organ and cellular targets of infection were identified in vivo. Viral specific antigens were detected by immunohistochemistry in liver, lung, spleen and lymph nodes cells.
Ramiro-Ibáñez, F., Martín-Alonso, José Manuel, García-Palencia, P., Parra, Francisco, Alonso Martí, Covadonga   +4 more
openaire   +5 more sources

New Variant of Rabbit Hemorrhagic Disease Virus, Portugal, 2012–2013

Emerging Infectious Diseases, 2013
The Portuguese Foundation for Science and Technology supported the doctoral fellowship of A.M.L. (SFRH/BD/78738/2011) and the postdoctoral fellowship of J.A. (SFRH/ BPD/73512/2010). The Portuguese Foundation for Science and Technology Projects PTDC/CVT/108490/2008 and FCT-ANR/ BIA-BIC/0043/2012 supported this work.
Abrantes, Joana, Lopes, Ana M., Dalton, Kevin Paul, Melo, P., Correia, J. J., Ramada, M., Alves, P. C., Parra Fernández, José Francisco, Esteves, Pedro J.   +8 more
openaire   +4 more sources

Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic [PDF]

Journal of Virology, 1996
A new rabbit calicivirus related to the rabbit hemorrhagic disease virus (RHDV) was identified. The new virus contains significant differences from the previously characterized RHDV isolates in terms of pathogenicity, viral titer, tropism, and primary sequence of the structural protein.
M L Pacciarini, P Fusi, C Rossi, Antonio Lavazza, Lorenzo Capucci   +4 more
openaire   +3 more sources

Transplanting neural stem cells overexpressing miRNA‐21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28‐let‐7 signaling pathway

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Intracerebral hemorrhage (ICH) remains a devastating neurological disorder with limited therapeutic options. Neural stem cell (NSC)‐based therapies have emerged as a potential regenerative approach, yet the molecular mechanisms regulating NSC behavior require further elucidation.
Wei Dai, Yongxia Li, Jiarui Du, Gang Shen, Meimei Fan, Zuopeng Su, Fulin Xu, Fang Yuan   +7 more
wiley   +1 more source

Rabbit Hemorrhagic Disease Virus Isolated from Diseased Alpine Musk Deer (Moschus sifanicus) [PDF]

Viruses, 2020
Rabbit hemorrhagic disease virus (RHDV) is the causative agent of rabbit hemorrhagic disease (RHD), and its infection results in mortality of 70–90% in farmed and wild rabbits. RHDV is thought to replicate strictly in rabbits. However, there are also reports showing that gene segments from the RHDV genome or antibodies against RHDV have been detected ...
Shijun Bao, Kai An, Chunguo Liu, Xiaoyong Xing, Xiaoping Fu, Huiwen Xue, Fengqin Wen, Xijun He, Jingfei Wang   +8 more
openaire   +4 more sources

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

Cancer Communications, EarlyView.
Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grade serous ovarian cancer (HGSOC), but the underlying ...
Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu   +11 more
wiley   +1 more source