Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor
MedComm, Volume 6, Issue 9, September 2025.Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang +9 more
wiley +1 more source
Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease
Emerging Infectious Diseases, 2016 We report a case of probable Zaire Ebola virus–related ophthalmologic complications in a physician from the United States who contracted Ebola virus disease in Liberia.
John R. Chancellor +12 more
doaj +1 more source
Ebola virus disease in West Africa — the first 9 Months of the epidemic and forward projections [PDF]
, 2014 BACKGROUND On March 23, 2014, the World Health Organization (WHO) was notified of an outbreak of Ebola virus disease (EVD) in Guinea. On August 8, the WHO declared the epidemic to be a "public health emergency of international concern." METHODS ...
Aylward, Bruce +61 more
core +2 more sources
Проблемы особо опасных инфекций, 2015 Objective of the study was to forecast the scale of the outbreak that would emerge after arrival of persons infected with Ebola virus into the Russian Federation.
V. B. Kirillov +2 more
doaj +1 more source
Mapping the zoonotic niche of Marburg virus disease in Africa. [PDF]
, 2015 BACKGROUND: Marburg virus disease (MVD) describes a viral haemorrhagic fever responsible for a number of outbreaks across eastern and southern Africa. It is a zoonotic disease, with the Egyptian rousette (Rousettus aegyptiacus) identified as a reservoir ...
Brady, Oliver J +7 more
core +2 more sources
Emergence of Lassa Fever Disease in Northern Togo: Report of Two Cases in Oti District in 2016
Case Reports in Infectious Diseases, 2017 Background. Lassa fever belongs to the group of potentially fatal hemorrhagic fevers, never reported in Togo. The aim of this paper is to report the first two cases of Lassa fever infection in Togo. Case Presentation.
Akouda Akessiwe Patassi +14 more
doaj +1 more source
Ebola virus disease: Essential clinical knowledge
Avicenna Journal of Medicine, 2017 Since its initial outbreak in 1976, Ebola virus disease (EVD) has affected thousands of people, causing severe illness with high mortality rates. In the absence of a vaccine or effective specific treatment, as well as the lack of early diagnostic and ...
Mahmoud Tawfik Khalafallah +3 more
doaj +1 more source
Crimean-Congo hemorrhagic fever in pregnancy: A systematic review and case series from Russia, Kazakhstan and Turkey. [PDF]
, 2017 Background Crimean-Congo hemorrhagic fever (CCHF) is acute viral infection and a major emerging infectious diseases threat, affecting a large geographical area. There is no proven antiviral therapy and it has a case fatality rate of 4–30%. The natural
Abuova, Gulzhan Narkenovna +8 more
core +4 more sources
Ebola Hemorrhagic Fever: Genetic Biomarkers and Vaccine Development [PDF]
Genetic Testing and Molecular Biomarkers, 2014 The Ebola virus causes a highly virulent systemic disease that involves viral hemorrhagic fever, affects multiple organ systems, and leads to internal bleeding and, in most cases, death. The World Health Organization estimates that as of August 31, 2014, there have been 3,685 cases and 1,841 deaths during the current outbreak (World Health Organization,
openaire +2 more sources
EBOV-RNA test with RT-PCR in ocular fluids of Ebola survivors can help to safely perform cataract surgery [PDF]
, 2018 Since the Ebola virus (EBOV) was discovered in 1976, the recent 2014−2016 Ebola virus disease (EVD) outbreak in West Africa was the largest with 28,600 cases and about 11,300 deaths.
Iozzo, Nicola, Spadea, Leopoldo
core +1 more source