Results 51 to 60 of about 82,726 (312)

Elevated l-threonine is a biomarker for Lassa fever and Ebola

Virology Journal, 2020
Background Lassa fever and Ebola are characterized by non-specific initial presentations that can progress to severe multisystem illnesses with high fatality rates.
Trevor V. Gale, John S. Schieffelin, Luis M. Branco, Robert F. Garry, Donald S. Grant   +4 more
doaj   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Crimean-Congo Hemorrhagic Fever in the One-Humped Camel (Camelus dromedarius) in East and Northeast of Iran

Journal of Arthropod-Borne Diseases, 2016
Background: This comprehensive study was conducted on multi-purpose one-humped camel (Camelus dromedarius) sera and ticks to assess the epidemiological aspects of the Crimean-Congo hemorrhagic fever virus (CCHFV) in northeast Iran. Methods: From May 2012
Mohsen Champour, Sadegh Chinikar, Gholamreza Mohammadi, Gholamreza Razmi, Ehsan Mostafavi, Nariman Shah-Hosseini, Sahar Khakifirouz, Tahmineh Jalali   +7 more
doaj  

Data set on Lassa fever in post-conflict Sierra Leone

Data in Brief, 2019
Lassa fever is a rodent-borne illness that is endemic to parts of sub-Saharan Africa, including Sierra Leone, Nigeria, and Guinea. The disease is named after the town of Lassa, Nigeria where it was discovered in 1969.
Jeffrey G. Shaffer, John S. Schieffelin, Donald S. Grant, Augustine Goba, Mambu Momoh, Lansana Kanneh, Danielle C. Levy, Jessica N. Hartnett, Matt L. Boisen, Luis M. Branco, Robert F. Garry   +10 more
doaj   +1 more source

Clinical and pathologic features of Crimean-Congo hemorrhagic fever

, 2007
This chapter describes the story of the clinical process starting from the entrance of the virus to the human body to the death, if happens. Humans are the only known host of Crimean-Congo hemorrhagic fever virus (CCHFV) in which disease is manifested ...

core   +1 more source

The early clinical features of dengue in adults: challenges for early clinical diagnosis. [PDF]

, 2011
BACKGROUND: The emergence of dengue throughout the tropical world is affecting an increasing proportion of adult cases. The clinical features of dengue in different age groups have not been well examined, especially in the context of early clinical ...
Chaterji, S., Lee-Ching Ng, Martin L. Hibberd, Chow, Angelia, Sharon W. S. Tan, Chua, C.R., Vasudevan Subhash G., Martin L Hibberd, Ooi Eng Eong, Leo Yee Sin, Choon Rong Chua, Chua Robert, Vasudevan, Subhash G, Chaterji, Shera, Leo, Yee Sin, Cheung, Yin Bun, Ng, Lee-Ching, Leo, Y.S., Chow, A., Ong Adrian, Cheung Yin Bun, Lim Wen Yan, Yin Bun Cheung, Chua Choon Rong, Adrian Ong, Yee Sin Leo, Low, Jenny GH, Hibberd, M.L., Subhash G Vasudevan, Low Jenny G. H., Ong, A., Cheung, Y.B., Ooi, E.E., Ng, L.-C., Low, J.G.H., Vasudevan, S.G., Jenny G. H. Low, Hibberd Martin L., Wen Yan Lim, Eng Eong Ooi, Tan Li Kiang, Lee, K.W., Jenny G H Low, Ong, Adrian, Lim, W.Y., Shera Chaterji, Chua, R., Koon Wui Lee, Tan Sharon W. S., Lim, Wen Yan, Ng Lee-Ching, Subhash G. Vasudevan, Lee Koon Wui, Robert Chua, Chaterji Shera, Ooi, Eng Eong, Hibberd, Martin L, Tan, L.K., Tan, S.W.S., Angelia Chow, Li Kiang Tan, Lee, Koon Wui, Tan, Sharon WS, Tan, Li Kiang, Sharon W S Tan, Chua, Choon Rong, Chua, Robert, Chow Angelia   +67 more
core   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Imported viral haemorrhagic fever with a potential for person-to-person transmission: review and recommendations for initial management of a suspected case in Belgium.

, 2002
Viral haemorrhagic fevers are caused by a wide range of viruses. There are 4 types of viruses well known to spread from person to person and able to cause nosocomial outbreaks with a high case fatality rate: an arenavirus (Lassa fever and more ...
Borchert, M., Moreau, M, Borchert, M, Colebunders, Robert, Colebunders, R, Moreau, M., Van Esbroeck, M., Van Esbroeck, M, Colebunders, R.   +8 more
core   +1 more source

Factors Affecting Recollapse of the Augmented Vertebrae After Percutaneous Vertebral Augmentation: A Prospective Study

AGING MEDICINE, EarlyView.
To investigate the relevant factors of augmented vertebrae recollapse after percutaneous vertebral augmentation (PVA) for the treatment of osteoporotic vertebral compression fractures (OVCFs). Intervertebral cleft (IVC) and those with PVP intervention are at higher risk of recollapse.
Yawen Zhang, Junchuan Liu, Maoyu Zhao, Yudian Qiu, Quan Ji, Nan Min, Qiang Wang   +6 more
wiley   +1 more source

Dordaviprone Maintenance After Allogeneic HCT for High‐Risk Acute Myeloid Leukemia and Myelodysplastic Neoplasm

American Journal of Hematology, EarlyView.
ABSTRACT Dordaviprone is a first‐in‐class small‐molecule imipridone. In preclinical studies, it is active against leukemia cells harboring a TP53 mutation or complex karyotype and leukemia stem cells while sparing normal bone marrow cells. This study aimed to determine the safety of dordaviprone maintenance after allogeneic hematopoietic cell ...
Vijaya Raj Bhatt, Christopher S. Wichman, Alyssa Bouska, Moataz Ellithi, Michael Haddadin, Javeed Iqbal, James E. Talmadge, Lori J. Maness, Krishna Gundabolu   +8 more
wiley   +1 more source