Results 51 to 60 of about 83,464 (331)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Suspected Crimean-Congo Haemorrhagic Fever Re-Infection: A Case Report with Atypical Serological Profile

Journal of Medical Microbiology and Infectious Diseases
A 53-year-old male farmer presented with clinical manifestations consistent with Crimean-Congo Hemorrhagic Fever (CCHF) virus infection, reporting a recent history of tick bite.
Mostafa Salehi-Vaziri, Tahmineh Jalali, Ali Asghar Bolandakhtar, Mehdi Fazlalipour, Ehsan Mostafavi, Sana Eybpoosh, Vahid Baniasadi, Mahsa Tavakoli, Tahereh Mohammadi, Sanam Azad-Manjiri, Motahareh Hosseini, Zahra Fereydouni, Mohammad Mehdi Gouya, Gary P Kobinger, Mohammad Hassan Pouriayevali   +14 more
doaj   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

A Case of Methotrexate Intoxication Misdiagnosed as Crimean-Congo Hemorrhagic Fever

Journal of Medical Microbiology and Infectious Diseases, 2016
[No Abstract] Crimean-Congo hemorrhagic fever (CCHF) is considered as the most important arboviral infection in Iran. Early diagnosis of CCHF is essential for preventing the spread of the infection and providing appropriate treatment to patients.
Mehdi Fazlalipour, Vahid Baniasadi, Mohammad Hassan Pouriayevali, Tahmineh Jalali, Tahereh Mohammadi, Sanam Azad-Manjiri, Yasaman Jamshidi, Sara Azizizadeh, Motahareh Hosseini, Sahar Khakifirouz, Mostafa Salehi-Vaziri   +10 more
doaj  

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Viral hemorrhagic fevers - a recurrent public health threat

Health Problems of Civilization, 2021
Viral hemorrhagic fevers (VHFs) caused by viruses are severe infectious diseases that lead to serious disturbances of the body’s homeostasis, in most cases accompanied by symptoms of hemorrhagic diathesis.
Marcin Weiner, Karolina Tarasiuk
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

No Detection of Crimean Congo Hemorrhagic Fever (CCHF) Virus in Ticks from Kerman Province of Iran

Journal of Medical Microbiology and Infectious Diseases, 2018
Introduction: Crimean Congo Hemorrhagic Fever (CCHF) is a fatal tick-borne viral zoonosis with a case fatality rate of 5% to 30%. CCHF has been documented as the most frequent tick-borne viral infection in Iran with more than 50 cases annually.
Sahar Khakifirouz, Seyed Javad Mowla, Vahid Baniasadi, Mehdi Fazlalipour, Tahmineh Jalali, Seyedeh Maryam Mirghiasi, Mostafa Salehi-Vaziri   +6 more
doaj  

Dengue and Other Viral Hemorrhagic Fevers

Indian Journal of Critical Care Medicine, 2021
How to cite this article: Shastri PS, Taneja S. Dengue and Other Viral Hemorrhagic Fevers. Indian J Crit Care Med 2021;25(Suppl 2):S130-S133.
Shastri, Prakash S, Taneja, Saurabh
openaire   +3 more sources