Results 61 to 70 of about 12,554 (250)

Bioterrorism [PDF]

, 2006
Terrorism preparedness is a highly specific component of general emergency preparedness. In addition to the unique pediatric issues involved in general emergency preparedness, terrorism preparedness must consider several additional issues, including the ...
Markenson, David, Redlener, Irwin E.
core   +2 more sources

High interferon type I responses in the lung, plasma and spleen during highly pathogenic H5N1 infection of chicken [PDF]

, 2011
This study shows that high pathogenic H5N1 influenza virus infection of chicken induced high levels of bioactive interferon type I in the lung (4.3 × 105 U/mg tissue), plasma (1.1 × 105 U/mL), and spleen (9.1 × 105 U/mg tissue).
Artur Summerfield, Hervé R Moulin, Laurence Guzylack-Piriou, Manuela Ocaña-Macchi, Matthias Liniger, Nicolas Ruggli, Sylvie Python   +6 more
core   +3 more sources

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Emergence of Crimean–Congo Hemorrhagic Fever Virus in Eastern Senegal in 2022

Viruses
Crimean–Congo hemorrhagic fever (CCHF), the most widespread tick-borne viral human infection, poses a threat to global health. In this study, clinical samples collected through national surveillance systems were screened for acute CCHF virus (CCHFV ...
Ousseynou Sene, Samba Niang Sagne, Déthié Ngom, Moussa Moise Diagne, Aminata Badji, Aliou Khoulé, El Hadji Ndiaye, Safietou Sankhe, Cheikh Loucoubar, Mawlouth Diallo, Manfred Weidmann, Ndongo Dia, Etienne Simon-Lorière, Yoro Sall, Boly Diop, Mamadou Ndiaye, Anavaj Sakuntabhai, Amadou Alpha Sall, Ousmane Faye, Oumar Faye, Diawo Diallo, Mamadou Aliou Barry, Gamou Fall   +22 more
doaj   +1 more source

European survey on laboratory preparedness, response and diagnostic capacity for crimean-congo haemorrhagic fever, 2012 [PDF]

, 2014
Crimean-Congo haemorrhagic fever (CCHF) is an infectious viral disease that has (re-)emerged in the last decade in south-eastern Europe, and there is a risk for further geographical expansion to western Europe.
Aberle, S.W. (Stephan), Alves, M.J. (M. João), Avsic, T. (Tatjana), Bosevska, G. (Golubinka), Bozovic, B. (Bojana), Brooks, T. (Tim), Brown, D.W.G. (D. W G), Capobianchi, M.R. (Maria Rosaria), Ceianu, C.S., Charrel, R. (Remi), Cherpillod, P. (Pascal), Christova, I., Donoso-Mantke, O., Dudman, S.G. (Susanne Gjeruldsen), Esbroeck, M. (M.) van, Fernandez-Garcia, M.D. (Maria Dolores), Franco, L. (Leticia), Golovljova, I., Griskevicius, A. (Algirdas), Jakupi, X. (Xhevat), Klempa, B., Korukluoglu, G., Kurolt, I.-C. (Ivan-Christian), Lundkvist, Å. (Åke), Markotic, A. (Alemka), Muscat, C. (Clive), Negredo, A., Niedrig, M., Pannetier, D. (Delphine), Papa, A. (Anna), Papa, A. (Anna), Platonov, A. (Alexander), Schmidt-Chanasit, J. (Jonas), Schutten, M. (Martin), Storozenko, J. (Jelena), Tenorio, A., Tenorio, A., Wölfel, R. (Roman), Zelena, H. (Hana), Zeller, H. (Hervé)   +39 more
core  

Tradeoffs between brain and digestive tissues across elevations in Typhlomys daloushanensis: evidence for sexual dimorphism

Wildlife Biology, EarlyView.
To cope with highly stochastic and/or heterogeneous environmental conditions, animals must balance energy resource allocation across physiological processes. The digestive tract and brain exhibit structural variations under strong developmental and selective pressures that vary across environmental gradients both between and within species.
Yimei Yan, Bangqing Chen, Jifa Cui, Chris Newman, Boyu Lei, Nan Wu, Jinwei Wu, Jin Zhao, Christina D. Buesching, Youbing Zhou   +9 more
wiley   +1 more source

Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis [PDF]

, 2015
Background The Ebola virus disease outbreak that started in Western Africa in 2013 was unprecedented because it spread within densely populated urban environments and affected many thousands of people.
Baron, Bertherat, Blackley, Burke, Christie, De Roo, Faye, Formenty, Hall, Julii Brainard, Katherine Pond, Kelly Edmunds, Kunii, Lee Hooper, Mackay, McElroy, Moreau, Mupere, Nyenswah, Nyenswah, Nyenswah, Olabode, Paul R Hunter, Schibler, Victory, Vladyko, World Health Organization   +26 more
core   +1 more source

Myeloablative Busulfan, Fludarabine and Melphalan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Childhood Myeloid Malignancy

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija, Fiona Kerr, Hazel Gough, Johnathan Soggee, Laurence C. Cheung, Rishi S. Kotecha, Shanti Ramachandran   +6 more
wiley   +1 more source

A community-engaged infection prevention and control approach to Ebola. [PDF]

, 2015
The real missing link in Ebola control efforts to date may lie in the failure to apply core principles of health promotion: the early, active and sustained engagement of affected communities, their trusted leaders, networks and lay knowledge, to help ...
Banya, Sama S, Corburn, Jason, Gibson, Nancy, Marais, Frederick, Mehtar, Shaheen, Minkler, Meredith, Mwau, Baraka, Ogunsola, Folasade   +7 more
core   +2 more sources

Assessing Risk Thresholds in Controlled Human Infection Models (CHIM)

Bioethics, EarlyView.
ABSTRACT Controlled Human Infection Models (CHIMs) are a type of clinical trial involving deliberately exposing human volunteers to an infectious agent. Compared to studies of natural infection, CHIMs offers distinctive benefits, from the ability to study presymptomatic infection to a direct assessment of the efficacy of vaccines and therapeutics in a ...
Alexa Nord‐Bronzyk, Barnaby Young, Jerry Menikoff, Julian Savulescu, G. Owen Schaefer   +4 more
wiley   +1 more source