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Structural Studies of Henipavirus Glycoproteins
VirusesHenipaviruses are a genus of emerging pathogens that includes the highly virulent Nipah and Hendra viruses that cause reoccurring outbreaks of disease. Henipaviruses rely on two surface glycoproteins, known as the attachment and fusion proteins, to facilitate entry into host cells.
Aaron J May +2 more
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Characterization of the Interactions between the Nucleoprotein and the Phosphoprotein of Henipavirus [PDF]
Journal of Biological Chemistry, 2011 The Henipavirus genome is encapsidated by the nucleoprotein (N) within a helical nucleocapsid that recruits the polymerase complex via the phosphoprotein (P). In a previous study, we reported that in henipaviruses, the N-terminal domain of the phosphoprotein and the C-terminal domain of the nucleoprotein (N(TAIL)) are both intrinsically disordered ...
Johnny Habchi +2 more
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A Zoonotic Henipavirus in Febrile Patients in China
New England Journal of Medicine, 2022Pan-He Zhang, Heng Ding, Lin-Fa Wang
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Functional studies of host-specific ephrin-B ligands as Henipavirus receptors
Virology, 2008 Hendra virus (HeV) and Nipah virus (NiV) are closely related paramyxoviruses that infect and cause disease in a wide range of mammalian hosts. To determine whether host receptor molecules play a role in species-specific and/or virus-specific infection we
Katharine N Bossart +2 more
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Pseudotyped Virus for Henipavirus
2023The genus Henipavirus (HNV) includes two virulent infectious viruses, Nipah virus (NiV) and Hendra virus (HeV), which are the focus of considerable public health research efforts and have been classified as priority infectious diseases by the World Health Organization.
Tao, Li +3 more
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Discovery and Genomic Characterization of a Novel Henipavirus, Angavokely Virus, from Fruit Bats in Madagascar [PDF]
Journal of Virology, 2022 International audienceThe genus Henipavirus (family Paramyxoviridae) currently comprises seven viruses, four of which have demonstrated prior evidence of zoonotic capacity.
Vololoniaina Raharinosy +2 more
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Ferret Models for Henipavirus Infection
2023Henipaviruses are emerging zoonotic viruses that can cause outbreaks of severe respiratory and neurological disease in humans and animals such as horses. The mechanism by which these viruses can cause disease remain largely unknown and to date there are no therapeutics or vaccines approved for use in humans.
Rockx, Barry, Mire, Chad E.
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Zoonotic henipavirus transmission
Journal of Clinical Virology, 2013Funding. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 355 Competing interests . . . . . . . . . . . . . . . . .
Barry, Rockx, Lin-Fa, Wang
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Assays for Detecting Henipavirus Antibodies
2023While molecular detection has increasingly become the detection method of choice for infectious diseases, antibody detection remains an important approach for diagnosis and surveillance. For henipaviruses, antibody detection methods such as ELISA and Western blot played a key role in the initial discovery of bats as the natural reservoir host. Here, we
Lin-Fa, Wang +3 more
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Evidence of Henipavirus Infection in West African Fruit Bats
PLoS ONE, 2008 Henipaviruses are emerging RNA viruses of fruit bat origin that can cause fatal encephalitis in man. Ghanaian fruit bats (megachiroptera) were tested for antibodies to henipaviruses. Using a Luminex multiplexed microsphere assay, antibodies were detected
David T S Hayman +2 more
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