Results 171 to 180 of about 5,865 (207)

Zoonotic henipavirus transmission

Journal of Clinical Virology, 2013
Funding. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 355 Competing interests . . . . . . . . . . . . . . . . .
Barry, Rockx, Lin-Fa, Wang
openaire   +2 more sources

Henipavirus receptor identified [PDF]

Nature Reviews Microbiology, 2005
exaly   +2 more sources

Assays for Detecting Henipavirus Antibodies

2023
While molecular detection has increasingly become the detection method of choice for infectious diseases, antibody detection remains an important approach for diagnosis and surveillance. For henipaviruses, antibody detection methods such as ELISA and Western blot played a key role in the initial discovery of bats as the natural reservoir host. Here, we
Lin-Fa, Wang, Shailendra, Mani, Chee Wah, Tan, Danielle E, Anderson   +3 more
openaire   +2 more sources

Structural Studies of Henipavirus Glycoproteins

Viruses
Henipaviruses are a genus of emerging pathogens that includes the highly virulent Nipah and Hendra viruses that cause reoccurring outbreaks of disease. Henipaviruses rely on two surface glycoproteins, known as the attachment and fusion proteins, to facilitate entry into host cells.
Aaron J May, Priyamvada Acharya
exaly   +4 more sources

Ferret Models for Henipavirus Infection

2023
Henipaviruses are emerging zoonotic viruses that can cause outbreaks of severe respiratory and neurological disease in humans and animals such as horses. The mechanism by which these viruses can cause disease remain largely unknown and to date there are no therapeutics or vaccines approved for use in humans.
Rockx, Barry, Mire, Chad E.
openaire   +3 more sources

Henipavirus pathogenesis and antiviral approaches

Expert Review of Anti-infective Therapy, 2015
Hendra virus and Nipah virus are closely related, recently emerged zoonotic paramyxoviruses, belonging to the Henipavirus genus. Both viruses induce generalized vasculitis affecting particularly the respiratory tract and CNS. The exceptionally broad species tropism of Henipavirus, the high case fatality rate and person-to-person transmission associated
Mathieu, Cyrille, Horvat, Branka
openaire   +3 more sources

Mouse Models of Henipavirus Infection

2023
The Nipah and Hendra viruses, belonging to henipavirus genus, are recently emerged zoonotic pathogens that cause severe and often fatal, neurologic, and/or respiratory diseases in both humans and various animals. As mice represent a small animal model convenient to study viral infections and provide a well-developed experimental toolbox for analysis in
Iampietro, Mathieu, Barron, Stéphane, Duthey, Aurélie, Horvat, Branka   +3 more
openaire   +4 more sources

Recombinant Soluble Henipavirus Glycoprotein Preparation

2023
Henipaviruses possess two envelope glycoproteins, the attachment (G) and the fusion (F) proteins that mediate cellular entry and are the major targets of virus-neutralizing antibody responses. Recombinant expression technologies have been used to produce soluble G and F proteins (sG and sF) that retain native-like oligomeric conformations and epitopes,
Lianying, Yan, Spencer L, Sterling, Deborah L, Fusco, Yee-Peng, Chan, Kai, Xu, Eric D, Laing, Christopher C, Broder   +6 more
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Recent progress in henipavirus research

Comparative Immunology, Microbiology and Infectious Diseases, 2007
Following the discovery of two new paramyxoviruses in the 1990s, much effort has been placed on rapidly finding the reservoir hosts, characterising the genomes, identifying the viral receptors and formulating potential vaccines and therapeutic options for these viruses, Hendra and Nipah viruses caused zoonotic disease on a scale not seen before with ...
Kim, Halpin, Bruce A, Mungall
openaire   +2 more sources

Modes of paramyxovirus fusion: a Henipavirus perspective [PDF]

Trends in Microbiology, 2011
Henipavirus is a new genus of Paramyxoviridae that uses protein-based receptors (ephrinB2 and ephrinB3) for virus entry. Paramyxovirus entry requires the coordinated action of the fusion (F) and attachment viral envelope glycoproteins. Receptor binding to the attachment protein triggers F to undergo a conformational cascade that results in membrane ...
Benhur Lee
exaly   +3 more sources