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Mouse Models of Henipavirus Infection
2023The Nipah and Hendra viruses, belonging to henipavirus genus, are recently emerged zoonotic pathogens that cause severe and often fatal, neurologic, and/or respiratory diseases in both humans and various animals. As mice represent a small animal model convenient to study viral infections and provide a well-developed experimental toolbox for analysis in
Iampietro, Mathieu +3 more
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Henipavirus pathogenesis and antiviral approaches
Expert Review of Anti-infective Therapy, 2015Hendra virus and Nipah virus are closely related, recently emerged zoonotic paramyxoviruses, belonging to the Henipavirus genus. Both viruses induce generalized vasculitis affecting particularly the respiratory tract and CNS. The exceptionally broad species tropism of Henipavirus, the high case fatality rate and person-to-person transmission associated
Mathieu, Cyrille, Horvat, Branka
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Recent progress in henipavirus research
Comparative Immunology, Microbiology and Infectious Diseases, 2007Following the discovery of two new paramyxoviruses in the 1990s, much effort has been placed on rapidly finding the reservoir hosts, characterising the genomes, identifying the viral receptors and formulating potential vaccines and therapeutic options for these viruses, Hendra and Nipah viruses caused zoonotic disease on a scale not seen before with ...
Kim, Halpin, Bruce A, Mungall
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Epidemiology of Henipavirus Disease in Humans
2012All seven recognized human cases of Hendra virus (HeV) infection have occurred in Queensland, Australia. Recognized human infections have all resulted from a HeV infected horse that was unusually efficient in transmitting the virus and a person with a high exposure to infectious secretions.
Stephen P, Luby, Emily S, Gurley
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A Henipavirus Vaccine in Sight
Science, 2012A candidate vaccine against Nipah and Hendra viruses, recently emerging zoonotic threats, looks promising.
Veronika von Messling, Roberto Cattaneo
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Recombinant Soluble Henipavirus Glycoprotein Preparation
2023Henipaviruses possess two envelope glycoproteins, the attachment (G) and the fusion (F) proteins that mediate cellular entry and are the major targets of virus-neutralizing antibody responses. Recombinant expression technologies have been used to produce soluble G and F proteins (sG and sF) that retain native-like oligomeric conformations and epitopes,
Lianying, Yan +6 more
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Infection and transmission of henipavirus in animals
Comparative Immunology, Microbiology and Infectious DiseasesHenipavirus (HNV) is well known for two zoonotic viruses in the genus, Hendra virus (HeV) and Nipah virus (NiV), which pose serious threat to human and animal health. In August 2022, a third zoonotic virus in the genus Henipavirus, Langya virus (LayV), was discovered in China.
Xinyu Qiu, Feng Wang, Ailong Sha
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Animal models of henipavirus infection: A review
The Veterinary Journal, 2009Hendra virus (HeV) and Nipah virus (NiV) form a separate genus Henipavirus within the family Paramyxoviridae, and are classified as biosafety level four pathogens due to their high case fatality rate following human infection and because of the lack of effective vaccines or therapy.
Hana M, Weingartl +2 more
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Henipavirus Membrane Fusion and Viral Entry
2012Nipah (NiV) and Hendra (HeV) viruses cause cell-cell fusion (syncytia) in brain, lung, heart, and kidney tissues, leading to encephalitis, pneumonia, and often death. Membrane fusion is essential to both viral entry and virus-induced cell-cell fusion, a hallmark of henipavirus infections.
Hector C, Aguilar, Ronald M, Iorio
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