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Ferret Models for Henipavirus Infection
2023Henipaviruses are emerging zoonotic viruses that can cause outbreaks of severe respiratory and neurological disease in humans and animals such as horses. The mechanism by which these viruses can cause disease remain largely unknown and to date there are no therapeutics or vaccines approved for use in humans.
Rockx, Barry, Mire, Chad E.
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Mouse Models of Henipavirus Infection
2023The Nipah and Hendra viruses, belonging to henipavirus genus, are recently emerged zoonotic pathogens that cause severe and often fatal, neurologic, and/or respiratory diseases in both humans and various animals. As mice represent a small animal model convenient to study viral infections and provide a well-developed experimental toolbox for analysis in
Iampietro, Mathieu +3 more
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Evidence of Henipavirus Infection in West African Fruit Bats
PLoS ONE, 2008 (Uploaded by Plazi for the Bat Literature Project) Henipaviruses are emerging RNA viruses of fruit bat origin that can cause fatal encephalitis in man. Ghanaian fruit bats (megachiroptera) were tested for antibodies to henipaviruses. Using a Luminex multiplexed microsphere assay, antibodies were detected in sera of Eidolon helvum to both Nipah (39%, 95%
James Wood +2 more
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Profiling Host MicroRNA Responses to Henipavirus Infection
2023Diseases caused by henipaviruses feature incubation periods of up to 16 days, during which infected animals may show no apparent signs of disease yet be capable of transmitting the virus to humans. This risk has prompted research into host-derived biomarkers for early disease detection. Here, we describe a methodology for the assaying of host microRNAs
Ryan J, Farr +5 more
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Animal models of henipavirus infection: A review
The Veterinary Journal, 2009Hendra virus (HeV) and Nipah virus (NiV) form a separate genus Henipavirus within the family Paramyxoviridae, and are classified as biosafety level four pathogens due to their high case fatality rate following human infection and because of the lack of effective vaccines or therapy.
Hana M, Weingartl +2 more
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Overview of Experimental Vaccines and Antiviral Therapeutics for Henipavirus Infection
2023Hendra virus (HeV) and Nipah virus (NiV) are highly pathogenic paramyxoviruses, which have emerged in recent decades and cause sporadic outbreaks of respiratory and encephalitic disease in Australia and Southeast Asia, respectively. Over two billion people currently live in regions potentially at risk due to the wide range of the Pteropus fruit bat ...
Benjamin A, Satterfield +2 more
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Low leukocyte count in Langya henipavirus and severity of infection
The Egyptian Journal of Haematology, 2022Aim The aim is to determine the leukocyte count in Langya henipavirus infection. Background The ‘Langya henipavirus’ is a brand new viral pathogen that first appeared in 2022. In the Chinese cities where this new virus was discovered, a big population was found with this infection ...
Rujittika Mungmunpuntipantip +1 more
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Infection and transmission of henipavirus in animals
Comparative Immunology, Microbiology and Infectious DiseasesHenipavirus (HNV) is well known for two zoonotic viruses in the genus, Hendra virus (HeV) and Nipah virus (NiV), which pose serious threat to human and animal health. In August 2022, a third zoonotic virus in the genus Henipavirus, Langya virus (LayV), was discovered in China.
Xinyu Qiu, Feng Wang, Ailong Sha
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Host Transcriptome Analysis of Ferret Tissues Following Henipavirus Infection
2023Ferrets are commonly used as experimental models of infection for a variety of viruses due to their susceptibility to human respiratory viruses and the close resemblance of pathological outcomes found in human infections. Even though ferret-specific reagents are limited, the use of ferrets as a preclinical experimental model of infection has gained ...
Tian S, Zeng +3 more
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Clinical and Pathological Manifestations of Human Henipavirus Infection
2012The clinicopathological features of human Nipah virus and Hendra virus infections appear to be similar. The clinical manifestations may be mild, but if severe, includes acute encephalitic and pulmonary syndromes with a high mortality. The pathological features in human acute henipavirus infections comprise vasculopathy (vasculitis, endothelial ...
Wong, K.T., Tan, C.T.
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