Results 11 to 20 of about 1,492 (99)

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science
Hendra and Nipah viruses (HNVs), zoonotic paramyxoviruses with >50% case fatality rates, cause fatal encephalitis and respiratory disease, yet lack approved therapies.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
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Structural Studies of Henipavirus Glycoproteins [PDF]

Viruses
Henipaviruses are a genus of emerging pathogens that includes the highly virulent Nipah and Hendra viruses that cause reoccurring outbreaks of disease.
Aaron J. May, Priyamvada Acharya
doaj   +2 more sources

Infectome analysis of bat kidneys from Yunnan province, China, reveals novel henipaviruses related to Hendra and Nipah viruses and prevalent bacterial and eukaryotic microbes. [PDF]

PLoS Pathogens
Bats are natural reservoirs for a wide range of microorganisms, including many notable zoonotic pathogens. However, the composition of the infectome (i.e., the collection of viral, bacterial and eukaryotic microorganisms) within bat kidneys remains ...
Guopeng Kuang, Tian Yang, Weihong Yang, Jing Wang, Hong Pan, Yuanfei Pan, Qin-Yu Gou, Wei-Chen Wu, Juan Wang, Lifeng Yang, Xi Han, Yao-Qing Chen, John-Sebastian Eden, Edward C Holmes, Mang Shi, Yun Feng   +15 more
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Henipavirus in Northern Short-Tailed Shrew, Alabama, USA [PDF]

Emerging Infectious Diseases
RNA metagenomic analysis of tissues from 4 wild-caught northern short-tailed shrews in Alabama, USA, revealed a novel henipavirus (family Paramyxoviridae).
Rhys H. Parry, KayLene Y.H. Yamada, Wendy R. Hood, Yang Zhao, Jinlong Y. Lu, Andrei Seluanov, Vera Gorbunova, Naphak Modhiran, Daniel Watterson, Ariel Isaacs   +9 more
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Prophylactic protection from lethal henipavirus disease mediated by Nipah-derived defective interfering particles is influenced by challenge virus strain and viral speciesResearch in context [PDF]

EBioMedicine
Summary: Background: Henipaviruses, including Nipah and Hendra viruses, are zoonotic pathogens that can cause severe respiratory and neurological diseases with high mortality rates in humans.
Stephen R. Welch, Jessica R. Spengler, Jessica R. Harmon, JoAnn D. Coleman-McCray, Sarah C. Genzer, Katherine A. Davies, Teresa E. Sorvillo, Florine E.M. Scholte, Sergio E. Rodriguez, Joel M. Montgomery, Stuart T. Nichol, Christina F. Spiropoulou   +11 more
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Serological and molecular analysis of henipavirus infections in synanthropic fruit bat and rodent populations in the Centre and North regions of Cameroon (2018–2020) [PDF]

BMC Veterinary Research
Background Bats and rodents have been identified as reservoirs for several highly pathogenic and zoonotic viruses including henipaviruses, a genus within the Paramyxoviridae family.
Cyrille Mbanwi Mbu’u, Pierre Gontao, Abel Wade, Maren Penning, Balal Sadeghi, Aristid Ekollo Mbange, Matthew LeBreton, Sylvain Leroy Sado Kamdem, Franziska Stoek, Martin Hermann Groschup, Wilfred Fon Mbacham, Anne Balkema-Buschmann   +11 more
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Pandemic potential of henipaviruses

Journal of Medical Science, 2023
Introduction and purpose. Hendra and Nipah are two highly dangerous zoonotic viruses belonging to the group of henipaviruses. Although they have been known for more than 20 years, no human drug or vaccine has been invented for them.
Aleksandra Wojtkiewicz, Maciej Szota, Kornelia Kędziora–Kornatowska   +2 more
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Evolution of Nipah Virus Infection: Past, Present, and Future Considerations

Tropical Medicine and Infectious Disease, 2021
Nipah virus (NiV) is a zoonotic paramyxovirus of the Henipavirus genus first identified in Malaysia in 1998. Henipaviruses have bat reservoir hosts and have been isolated from fruit bats found across Oceania, Asia, and Africa.
Naomi Hauser, Alexis C. Gushiken, Shivakumar Narayanan, Shyam Kottilil, Joel V. Chua   +4 more
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Development of a Porcine Cell Line Stably Expressing Ephrin-B2 for Nipah Virus Research and Diagnostic Testing. [PDF]

Microbiol Immunol
ABSTRACT Nipah virus (NiV) is a highly pathogenic zoonotic virus transmitted from bats to humans through pigs as a crucial intermediate host. NiV outbreaks pose significant public health and economic threats, especially for pig farmers. Although the World Organization for Animal Health recommends African green monkey‐derived Vero cells for NiV ...
Zhang H, Saito A.
europepmc   +2 more sources

The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import

Cells, 2020
Nipah and Hendra viruses are highly pathogenic, zoonotic henipaviruses that encode proteins that inhibit the host’s innate immune response. The W protein is one of four products encoded from the P gene and binds a number of host proteins to regulate ...
Sofiya Tsimbalyuk, Emily M. Cross, Mikayla Hoad, Camilla M. Donnelly, Justin A. Roby, Jade K. Forwood   +5 more
doaj   +1 more source