Ecology and EvolutionBats are known to host zoonotic viruses, including henipaviruses that cause high fatality rates in humans (Nipah virus and Hendra virus). However, the determinants of zoonotic spillover are generally unknown, as the ecological and demographic drivers of ...
Maya M. Juman +15 more
doaj +2 more sources
Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein
Advanced ScienceHendra and Nipah viruses (HNVs), zoonotic paramyxoviruses with >50% case fatality rates, cause fatal encephalitis and respiratory disease, yet lack approved therapies.
Yi Ren +19 more
doaj +2 more sources
Humans are urged to be vigilant against spillback infection of new henipaviruses
Frontiers in Immunology, 2022 Hao Yuan +8 more
exaly +3 more sources
Infectome analysis of bat kidneys from Yunnan province, China, reveals novel henipaviruses related to Hendra and Nipah viruses and prevalent bacterial and eukaryotic microbes. [PDF]
PLoS PathogensBats are natural reservoirs for a wide range of microorganisms, including many notable zoonotic pathogens. However, the composition of the infectome (i.e., the collection of viral, bacterial and eukaryotic microorganisms) within bat kidneys remains ...
Guopeng Kuang +15 more
doaj +2 more sources
Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses [PDF]
Nature Communications, 2017 The attachment glycoprotein (HNV-G) of henipaviruses interacts with host receptors at the cell surface and is a major determinant of species tropism. Here the authors provide structural and functional evidence that the emergent henipavirus, Mòjiang virus,
Ilona Rissanen +8 more
doaj +2 more sources
Henipavirus in Northern Short-Tailed Shrew, Alabama, USA [PDF]
Emerging Infectious DiseasesRNA metagenomic analysis of tissues from 4 wild-caught northern short-tailed shrews in Alabama, USA, revealed a novel henipavirus (family Paramyxoviridae).
Rhys H. Parry +9 more
doaj +2 more sources
Beyond the Headlines: Why Henipaviruses Warrant Our Attention
Acta Medica (Hradec Kralove, Czech Republic)Henipaviruses, including Hendra and Nipah viruses, represent significant zoonotic threats with higher mortality rates. Due to limited therapeutic interventions, poses substantial challenges. These bat-borne pathogens were first identified in Australia (Hendra, 1994) and Malaysia (Nipah, 1998–1999), with subsequent multiple outbreaks.
Biplab Adhikari
openaire +4 more sources
Serological and molecular analysis of henipavirus infections in synanthropic fruit bat and rodent populations in the Centre and North regions of Cameroon (2018–2020) [PDF]
BMC Veterinary ResearchBackground Bats and rodents have been identified as reservoirs for several highly pathogenic and zoonotic viruses including henipaviruses, a genus within the Paramyxoviridae family.
Cyrille Mbanwi Mbu’u +11 more
doaj +2 more sources
Prophylactic protection from lethal henipavirus disease mediated by Nipah-derived defective interfering particles is influenced by challenge virus strain and viral speciesResearch in context [PDF]
EBioMedicineSummary: Background: Henipaviruses, including Nipah and Hendra viruses, are zoonotic pathogens that can cause severe respiratory and neurological diseases with high mortality rates in humans.
Stephen R. Welch +11 more
doaj +2 more sources
Sequence-encoded determinants drive distinct early aggregation pathways and different structural outcomes in PNT1 fibrils across Henipavirus members. [PDF]
Protein SciAbstract Protein aggregation is increasingly recognized as a biologically relevant process in viral proteins, yet the molecular determinants governing such phenomena remain poorly understood. Intrinsically disordered proteins (IDPs) are ubiquitous in viral proteomes, where conformational plasticity not only enables functional diversity but also permits
Sawdekar H +6 more
europepmc +2 more sources