Results 51 to 60 of about 1,492 (99)

Ebolavirus evolution and emergence are associated with land use change

Ecological Monographs, Volume 95, Issue 1, February 2025.
Abstract Anthropogenic land use change facilitates disease emergence by altering the interface between humans and pathogen reservoirs and is hypothesized to drive pathogen evolution. Here, we show a positive association between land use change and the evolution and dispersal of Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV).
Christian E. Lange, Thomas R. Barnum, David J. McIver, Matthew LeBreton, Karen Saylors, Charles Kumakamba, Sara Lowes, Eduardo Montero, Robert L. Cohen   +8 more
wiley   +1 more source

Dissecting Henipavirus W proteins conformational and fibrillation properties: contribution of their N‐ and C‐terminal constituent domains

The FEBS Journal, Volume 292, Issue 3, Page 556-581, February 2025.
The W proteins of Nipah and Hendra viruses exhibit fibrillation abilities in vitro, which have been attributed to the intrinsically disordered N‐terminal domain (NTD). Our research shows that the C‐terminal domain (CTD) of both viruses is intrinsically disordered and non‐fibrillogenic.
Giulia Pesce, Frank Gondelaud, Denis Ptchelkine, Christophe Bignon, Patrick Fourquet, Sonia Longhi   +5 more
wiley   +1 more source

The Current Pathogenicity and Potential Risk Assessment of Nipah Virus as Potential Cause of “Disease X”: A Narrative Review

Health Science Reports, Volume 7, Issue 12, December 2024.
ABSTRACT Background and Aims The World Health Organization (WHO) recognized the potential for a severe international epidemic and introduced the term “Disease X” to classify pathogens that not yet identified. The Nipah virus (NiV) is highly dangerous due to its zoonotic nature, high mortality rate, and ability to cause severe clinical symptoms in ...
Samiha Mehnaz, Ramisa Anjum, Fatema Rahman Mithila, Syed Masudur Rahman Dewan, Md. Rabiul Islam   +4 more
wiley   +1 more source

The Unique Immune System of Bats: An Evolutionary Analysis and Bibliometric Study

Ecology and Evolution, Volume 14, Issue 11, November 2024.
Through the evolutionary and bibliometric analyses, this study identified several critical immune genes and signaling pathways related to bat immunity. Currently, research on the immune system of bats primarily focuses on the themes of “efficient antiviral responses” and “inflammation suppression.” ABSTRACT Bats exhibit a greater capacity to tolerate ...
Rui Li, Wenliang Zhao, Apeng Chen, Zhiqiang Wu, Gejing De   +4 more
wiley   +1 more source

Current progress towards prevention of Nipah and Hendra disease in humans: A scoping review of vaccine and monoclonal antibody candidates being evaluated in clinical trials

Tropical Medicine &International Health, Volume 29, Issue 5, Page 354-364, May 2024.
Abstract Objectives Nipah and Hendra are deadly zoonotic diseases with pandemic potential. To date, no human vaccine or monoclonal antibody (mAb) has been licensed to prevent disease caused by these pathogens. The aim of this scoping review was to identify and describe all Phase I, II, and III clinical trials of vaccine candidates or mAbs candidates ...
Valerie Rodrigue, Katie Gravagna, Jacqueline Yao, Vaidehi Nafade, Nicole E. Basta   +4 more
wiley   +1 more source

Structural basis for antibody recognition of vulnerable epitopes on Nipah virus F protein

Nature Communications, 2023
Henipaviruses such as Nipah virus (NiV) cause severe encephalitis with high fatality rates in humans. NiV fusion (F) glycoprotein is a key target of the host immune response. Here, Byrne et al.
Patrick O. Byrne, Brian E. Fisher, David R. Ambrozak, Elizabeth G. Blade, Yaroslav Tsybovsky, Barney S. Graham, Jason S. McLellan, Rebecca J. Loomis   +7 more
doaj   +1 more source

Henipaviruses-A constant threat to livestock and humans.

PLoS Neglected Tropical Diseases, 2022
In this review, we highlight the risk to livestock and humans from infections with henipaviruses, which belong to the virus family Paramyxoviridae. We provide a comprehensive overview of documented outbreaks of Nipah and Hendra virus infections affecting
Susann Kummer, Denise-Carina Kranz
doaj   +1 more source

Cedar virus: a novel Henipavirus isolated from Australian bats.

PLoS Pathogens, 2012
The genus Henipavirus in the family Paramyxoviridae contains two viruses, Hendra virus (HeV) and Nipah virus (NiV) for which pteropid bats act as the main natural reservoir.
Glenn A Marsh, Carol de Jong, Jennifer A Barr, Mary Tachedjian, Craig Smith, Deborah Middleton, Meng Yu, Shawn Todd, Adam J Foord, Volker Haring, Jean Payne, Rachel Robinson, Ivano Broz, Gary Crameri, Hume E Field, Lin-Fa Wang   +15 more
doaj   +1 more source

Distinct Cell Transcriptomic Landscapes Upon Henipavirus Infections

Frontiers in Microbiology, 2020
Hendra virus (HeV) and Cedar virus (CedV) are henipaviruses, which fall into the Paramyxoviridae family of single-stranded, negative-sense RNA viruses. HeV is classified as a Biosafety Level-4 (BSL-4) agent, as it is highly pathogenic and is often fatal ...
Mingyue Chen, Mingyue Chen, Mingyue Chen, Mary Tachedjian, Glenn A. Marsh, Jie Cui, Jie Cui, Lin-Fa Wang, Lin-Fa Wang   +8 more
doaj   +1 more source

Pathology and host-pathogen interactions in a golden Syrian hamster model of Nipah virus infection

Frontiers in Veterinary Science
Nipah virus (NiV) is recognized as one of the key pathogens with pandemic potential. We have recently established a NiV hamster model, which reproduces a highly similar disease to that observed in human cases, including respiratory and neurological signs
Inés Ruedas-Torres, Stephen Findlay-Wilson, Emma Kennedy, Stuart Dowall, Francisco Javier Salguero   +4 more
doaj   +1 more source