Results 71 to 80 of about 29,438 (248)

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

²²⁵Ac-rHDL Nanoparticles: A Potential Agent for Targeted Alpha-Particle Therapy of Tumors Overexpressing SR-BI Proteins

Molecules, 2022
Actinium-225 and other alpha-particle-emitting radionuclides have shown high potential for cancer treatment. Reconstituted high-density lipoproteins (rHDL) specifically recognize the scavenger receptor B type I (SR-BI) overexpressed in several types of ...
Tania Hernández-Jiménez, Guillermina Ferro-Flores, Enrique Morales-Ávila, Keila Isaac-Olivé, Blanca Ocampo-García, Liliana Aranda-Lara, Clara Santos-Cuevas, Myrna Luna-Gutiérrez, Laura De Nardo, Antonio Rosato, Laura Meléndez-Alafort   +10 more
doaj   +1 more source

Addressing Oxygen Embrittlement in Additively Manufactured Titanium via Cu‐Mediated Interstitial Site Engineering

Advanced Science, EarlyView.
A novel “Cu‐mediated interstitial site engineering” strategy is introduced to thermodynamically stabilize hexagonal oxygen (hex‐O) configurations in oxygen‐containing titanium alloys. The hex‐O configuration activates multiple slip systems and enhances dislocation pinning via long‐range repulsion.
Xiaobin Lin, Xudong Rong, Jiachen Xie, Xinru Wang, Jianteng Wang, Zhihang Xu, Dongdong Zhao, Shiwei Pan, Feng Qian, Longlong Ma, Gang Sha, Xiang Zhang, Chunsheng Shi, Chunnian He, Naiqin Zhao   +14 more
wiley   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

Redox‐Programmed Activation of a Dual‐Modal Probe for High‐Fidelity Tumor Delineation and Image‐Guided Surgery

Advanced Science, EarlyView.
This study presents a glutathione (GSH)‐activatable dual‐modality probe (GAP9) with a redox‐tuned activation window for precise tumor detection. It remains quenched (“OFF”) in normal tissue yet activates specifically in tumors for T1‐weighted magnetic resonance imaging (MRI) preoperative mapping and near‐infrared II (NIR‐II) fluorescence intraoperative
Haohao Yan, Yanbin Feng, Qian Jia, Ruili Zhang, Zhongliang Wang   +4 more
wiley   +1 more source

Molecular Docking Studies on Methanolic Propolis Extracts Collected from Different Regions in Saudi Arabia as a Potential Inhibitor of Topoisomerase IIβ

Separations, 2022
Propolis is a sticky substance made by honeybees from various plant parts that is rich in biologically active substances such as flavonoids, phenolic acids, and phenolics and has a wide range of applications in the food, cosmetics, and pharmaceutical ...
Areej A. Al-Khalaf, Ibrahim Alabdelkareem, Salim S. Al-Rejaie, Mohamed Mohany, Wael N. Hozzein   +4 more
doaj   +1 more source

The role of Coenzyme Q10 in statin-associated myopathy [PDF]

, 2009
Statins, or 3-hydroxyl-3-methylglutaryl coenzyme HMG-CoA reductase inhibitors,\ud are cholesterol-lowering drugs which are frequently used in the primary and secondary\ud prevention of coronary artery disease. Current research and recommendations support\
Kalra, Dr Sanjay
core  

Cell micropatterning inside a microchannel and assays under a stable concentration gradient [PDF]

, 2010
We describe the use of a microfluidic device to micropattern cells in a microchannel and investigated the behavior of these cells under a concentration gradient.
Fukuda Junji, Okuyama Tomoaki, Seto Yuki, Suzuki Hiroaki, Yamazoe Hironori, 福田 淳二, 鈴木 博章   +6 more
core   +1 more source

Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum

Clinical Anatomy, EarlyView.
ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery, Andrew C. Hall, Thomas H. Gillingwater, Afaf Alsolami, Abduelmenem Alashkham   +4 more
wiley   +1 more source

Estrogen-induced epigenetic silencing of FTH1 and TFRC genes reduces liver cancer cell growth and survival

Epigenetics, 2020
Estrogen (E2) regulates hundreds of genes involved in cell metabolism and disrupts iron homoeostasis in various cell types. Herein, we addressed whether E2-induced epigenetic modifications are involved in modulating the expression of iron-regulatory ...
Jibran Sualeh Muhammad, Khuloud Bajbouj, Jasmin Shafarin, Mawieh Hamad   +3 more
doaj   +1 more source