Results 191 to 200 of about 2,060,229 (274)

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

Beyond-Rule-of-Five Compounds Are Not Different: In Vitro-In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set. [PDF]

Pharmaceuticals (Basel)
Maurer CK, Fang Z, Duevel HM, Harlfinger S, Petersson C.   +4 more
europepmc   +1 more source

Genomic context analysis enables the discovery of an unusual NAD‐dependent racemase in phosphonate catabolism

The FEBS Journal, EarlyView.
The authors identify PbfF (previously annotated as a NAD‐dependent dehydrogenase) as a hitherto unknown enzyme in phosphonate catabolism. Guided by genome context analysis, they show that PbfF is actually a racemase, serving to degrade the natural compound (S)‐2‐amino‐1‐hydroxyethylphosphonate (S‐HAEP).
Francesca Ruffolo, Silvia Conciatori, Giovanni Merici, Tamara Dinhof, Jason P. Chin, Claudio Rivetti, Andrea Secchi, Katharina Pallitsch, Alessio Peracchi   +8 more
wiley   +1 more source

Bioactive Polysaccharides from <i>Hericium erinaceus</i>: Extraction, Structure, Bioactivities, and Applications. [PDF]

Molecules
Ge F, Chen Y, Wang B, Zhou W, Du B, Hou L.   +5 more
europepmc   +1 more source

Mild Acidic pH Inhibition of the Major Pathway of Herpes Simplex Virus Entry into HEp-2 Cells

, 1989
Ken S. Rosenthal, Jeanette Killius, Cheryl M. Hodnichak, Tom M. Venetta, L. Gyurgyik, Karen E. Janiga   +5 more
openalex   +1 more source

Mining bioactive components in agricultural crop and food production residue for sustainable solutions: In silico screening for skin anti‐ageing properties

International Journal of Cosmetic Science, EarlyView.
A workflow for identifying sustainable anti‐ageing solutions from agricultural crop and food production residues (ACFPR). A combination of in silico techniques, like database interrogations, target predictions, molecular docking, and ADME predictions can pave the way for the development of innovative, eco‐friendly anti‐ageing cosmetics.
Senka Vidović, Milan Ilić, Jelena Nakomčić, Nataša Nastić, Jelena Kvrgić, Xuanpeng Song, Dimitar Jakimov, Aleksandra Jovanović Galović, Nataša Lješković Jovanović, Mire Zloh   +9 more
wiley   +1 more source

Biosynthesis of silver nanoparticles by Talaromyces funiculosus for therapeutic applications and safety evaluation. [PDF]

Sci Rep
El Deeb BA, Faheem GG, Bakhit MS.
europepmc   +1 more source

Objective sleep monitoring at home in older adults: A scoping review

Journal of Sleep Research, EarlyView.
Summary Inadequate sleep in older adults is linked to health issues such as frailty, cognitive impairment and cardiovascular disorders. Maintaining regular sleep patterns is important for healthy aging, making effective sleep monitoring essential.
Sarah Nauman Ghazi, Anders Behrens, Jessica Berner, Johan Sanmartin Berglund, Peter Anderberg   +4 more
wiley   +1 more source

Dual-Mode Treatment of Hepatocellular Carcinoma Using RGD Cyclopeptide-Modified Liposomes Loaded with Ce6/DOX. [PDF]

Int J Nanomedicine
Xu W, Zheng J, Zhang J, Shi H, Peng W, Liu Y, Feng G, Wang Y, Liang YJ, Chen J.   +9 more
europepmc   +1 more source

Mechanisms governing bacterial capsular polysaccharide attachment and chain length

Annals of the New York Academy of Sciences, EarlyView.
Abstract Capsular polysaccharides (CPSs) are high‐molecular weight glycopolymers that form a capsule layer on the surface of many bacterial species. This layer serves as a crucial barrier between bacteria and their environment, protecting them from host immune responses and environmental stressors while facilitating adaptation to host niches.
Saroj Khadka, Emily L. Kinney, Brooke E. Ryan, Laura A. Mike   +3 more
wiley   +1 more source