Results 71 to 80 of about 41,094 (191)

Mutational Analysis of the Bovine Hepacivirus Internal Ribosome Entry Site [PDF]

Journal of Virology, 2018
Several members of the family Flaviviridae , including HCV, have adapted cap-independent translation strategies to overcome canonical eukaryotic translation pathways and use cis -acting RNA-elements, designated viral internal ribosome entry sites (IRES), to initiate translation.
A L, Baron, A, Schoeniger, P, Becher, C, Baechlein   +3 more
openaire   +2 more sources

From Bat to Worse: The Pivotal Role of Bats for Viral Zoonosis

Microbial Biotechnology, Volume 18, Issue 7, July 2025.
Thanks to a dampened inflammatory innate immune response, various Chiropteran (bat) species frequently carry ‐ without showing symptoms – diverse viruses that can cause severe diseases in humans. The reasons why bats are a pivotal virus reservoir for emerging viral diseases are discussed in this Lilliput contribution.
Harald Brüssow
wiley   +1 more source

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Hepatitis C Virus Saint Petersburg Variant Detection With Machine Learning Methods

Journal of Medical Virology, Volume 97, Issue 2, February 2025.
ABSTRACT Hepatitis C virus infection is a significant global health concern, affecting millions worldwide. Although direct‐acting antivirals achieve over 90% success rate, treatment failures still occur, particularly when pan‐genotypic DAAs are unavailable, and drugs need to be chosen based on the present HCV genotype.
Nurhan Arslan, Bernhard Reuter, Joachim Buech, Thomas Lengauer, Martin Obermeier, Rolf Kaiser, Nico Pfeifer   +6 more
wiley   +1 more source

HepacivirusInfection in Domestic Horses, Brazil, 2011–2013

Emerging Infectious Diseases, 2014
To the Editor: An estimated ≈150 million persons (3% of the world population) are chronically infected with hepatitis C virus (HCV). This virus is the prototype of the genus Hepacivirus and a major cause of liver cirrhosis and hepatocellular carcinoma around the world.
Bernard Salame Gemaque, Alex Junior Souza de Souza, Manoel do Carmo Pereira Soares, Andreza Pinheiro Malheiros, Andrea Lima Silva, Max Moreira Alves, Michele Soares Gomes-Gouvêa, João Renato Rebello Pinho, Heriberto Ferreira de Figueiredo, Djacy Barbosa Ribeiro, Jonan Souza da Silva, Leopoldo Augusto Moraes, Ana Silvia Sardinha Ribeiro, Washington Luiz Assunção Pereira   +13 more
openaire   +3 more sources

Comprehensive Enteroviral Serology Links Infection and Anti‐Melanoma Differentiation‐Associated Protein 5 Dermatomyositis

ACR Open Rheumatology, Volume 7, Issue 1, January 2025.
Objective Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous, systemic autoimmune diseases characterized by specific clinical features and, frequently, skeletal muscle inflammation. Specific subtypes of IIMs can be characterized by myositis‐specific autoantibodies and are associated with distinct clinical phenotypes.
Sahana Jayaraman, Eleni Tiniakou, William R. Morgenlander, Miso Na, Lisa Christopher‐Stine, H. Benjamin Larman   +5 more
wiley   +1 more source

A highly divergent hepacivirus-like flavivirus in domestic ducks

Journal of General Virology, 2019
Using random amplification and reverse transcription-PCR, a novel RNA virus was detected in sera of domestic ducks. The full genome of the virus was determined for three strains, identifying the first hepacivirus-like flavivirus in birds. The virus, that we tentatively named duck hepacivirus-like virus (DuHV), possesses several unique molecular ...
Lili Chu, Meiling Jin, Chonglun Feng, Xiaoyan Wang, Dabing Zhang   +4 more
openaire   +2 more sources

Influence of Host and Landscape‐Associated Factors in the Infection and Transmission of Pathogens: The Case of Directly Transmitted Virus in Mammals

Veterinary Medicine and Science, Volume 11, Issue 1, January 2025.
The figure shows the effects (increasing upward arrow or decreasing downward arrow) the most common host traits, landscape attributes, climatic features and anthropogenic variables recorded in the review had on the infection and transmission of directly transmitted virus to mammals.
María del Carmen Villalobos‐Segura, Oscar Rico‐Chávez, Gerardo Suzán, Andrea Chaves   +3 more
wiley   +1 more source

Equine hepacivirus persistent infection in a horse with chronic wasting

Transboundary and Emerging Diseases, 2017
Equine hepacivirus is the closest homologue of hepatitis C virus. Limited data on the clinical features of this infection are available. We report the identification of a horse with high-titre viremia by equine hepacivirus. Over a 15-month follow-up, the clinical signs and the viremic status persisted, suggesting a chronic evolution.
G. Elia, G. Lanave, E. Lorusso, A. Parisi, A. Trotta, R. Buono, V. Martella, N. Decaro, C. Buonavoglia   +8 more
openaire   +3 more sources

Final Report of Unmet Needs of Interferon-Based Therapy for Chronic Hepatitis C in Korea: Basis for Moving into the Direct-Acting Antiviral Era

Gut and Liver, 2017
Background/AimsTo evaluate the era of direct acting antivirals (DAAs), we must understand the treatment patterns and outcomes of interferon-based therapy for hepatitis C virus (HCV) infection.
Eun Sun Jang, Young Seok Kim, Kyung-Ah Kim, Youn Jae Lee, Woo Jin Chung, In Hee Kim, Byung Seok Lee, Sook-Hyang Jeong   +7 more
doaj   +1 more source