Mutations within the hepatitis C virus genotype 1b E2-PePHD domain do not correlate with treatment outcome. [PDF]
, 2005 The hepatitis C virus (HCV) envelope protein 2 (E2) interacts in vitro with the interferon alpha (IFN-alpha)-inducible double-stranded RNA-activated protein kinase, suggesting a possible mechanism by which HCV may evade the antiviral effects of IFN-alpha.
C. Gaudy-Graffin +5 more
core +2 more sources
Ecologic Traits Analysis for Identifying Rodent Hosts for Arenavirus and Hepacivirus in the Americas
Biotropica, Volume 57, Issue 6, November 2025.Over half of emerging human pathogens originate from wildlife, with rodents serving as key zoonotic hosts. This study used ecological trait‐based models to identify rodent traits associated with arenavirus and hepacivirus infections and detect potential host species across the Americas, our models achieve high predictive accuracy (AUC = 0.92–0.96).
María del Carmen Villalobos‐Segura +3 more
wiley +1 more source
Evaluation of ribavirin efficacy and tolerance in subjects with chronic hepatitis C virus infection [PDF]
Vojnosanitetski Pregled, 2002 Background. Reports by hepatologists indicated that anti-HCV antibodies might be detected in 71% to 84% of cases of post-transfusion hepatitis and in up to 50% of cases of sporadic non-A non-B hepatitis.
Stanimirović Violeta +4 more
doaj +1 more source
Journal of Medical Virology, Volume 97, Issue 9, September 2025.ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti +11 more
wiley +1 more source
Treatment outcomes for equine osteoarthritis with mesenchymal stromal cells and hyaluronic acid
Equine Veterinary Journal, Volume 57, Issue 5, Page 1245-1254, September 2025.Abstract Background Mesenchymal stromal cells (MSCs) are widely used to treat osteoarthritis (OA). Optimising dose, timing, and safety while comparing efficacy with standard therapies like hyaluronic acid (HA) is essential for their standardisation. Objectives To assess the safety and efficacy of equine umbilical cord‐derived (eCB) MSCs in client‐owned
Rodrigo Munevar Luque +6 more
wiley +1 more source
Gut and Liver, 2017 Background/AimsThe approval of sofosbuvir (SOF), a direct-acting antiviral, has revolutionized the treatment of chronic hepatitis C virus (HCV).Methods : We assessed the sustained virological response (SVR) of SOF-based regimens in a real-world single ...
Hyun Phil Shin +8 more
doaj +1 more source
Development of diagnostic methods and study of the immunoreactivity of a mixture of recombinant core and E2 proteins fused to GST with control serum positive for hepatitis C [PDF]
, 2013 The hepatitis C virus (HCV) is an enveloped virus that is about 50–70nm in diameter, has positive-strand RNA, and belongs to the genus Hepacivirus and the family Flaviridae.
Kenfe, Flávia Regina +5 more
core +1 more source
The Small Cysteine‐Rich Protein of Potato Mop‐Top Virus Exhibits Viroporin Activity
Molecular Plant Pathology, Volume 26, Issue 9, September 2025.The cysteine‐rich 8K protein of PMTV exhibits a viroporin activity that forms multimers on endomembrane, alters membrane permeability, and conducts potassium and protons. ABSTRACT Potato mop‐top virus (PMTV) is the causal agent of potato tuber spraing disease, which causes significant economic losses to potato production worldwide.
Ye Liu +9 more
wiley +1 more source
Gut and Liver, 2017 Background/AimsThe association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea.
Joo Yeong Baeg +9 more
doaj +1 more source
Comparative evaluation of the total hepatitis C virus core antigen, branched-DNA, and amplicor monitor assays in determining viremia for patients with chronic hepatitis C during interferon plus ribavirin combination therapy. [PDF]
, 2003 An assay prototype designed to detect and quantify total hepatitis C virus [HCV] core antigen (HCV core Ag) protein in serum and plasma in the presence or absence of anti-HCV antibodies has been recently developed by Ortho-Clinical Diagnostics.
P. Veillon +5 more
core +2 more sources