Results 81 to 90 of about 41,094 (191)

Hepatitis C in North Africa: A Comprehensive Review of Epidemiology, Genotypic Diversity, and Hepatocellular Carcinoma

Advances in Virology, Volume 2025, Issue 1, 2025.
Hepatitis C virus (HCV) is implicated in carcinogenic infections like hepatocellular carcinoma (HCC). Given that no HCV vaccine is currently available, comprehensive epidemiological understanding is crucial for devising effective prevention strategies.
Samia Boukaira, Salma Madihi, Hind Bouafi, Zineb Rchiad, Bouchra Belkadi, Abdelouaheb Benani, Ahmed Majeed Al-Shammari   +6 more
wiley   +1 more source

Comprehensive evolutionary and phylogenetic analysis of Hepacivirus N (HNV)

Journal of General Virology, 2018
Hepaciviruses (HVs) have been detected in several domestic and wild animals and present high genetic diversity. The actual classification divides the genus Hepacivirus into 14 species (A-N), according to their phylogenetic relationships, including the bovine hepacivirus [Hepacivirus N (HNV)].
M S, da Silva, D M, Junqueira, L F, Baumbach, S P, Cibulski, A C S, Mósena, M N, Weber, S, Silveira, G M, de Moraes, R D, Maia, V C S, Coimbra, C W, Canal   +10 more
openaire   +2 more sources

Metatranscriptomic Analysis Uncovers RNA Virus Diversity in Ticks From the China–Russia–North Korea Border Region

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Ticks serve as critical viral vectors, and border regions, acting as convergence zones of complex ecosystems, provide diverse habitats for ticks and their hosts, thereby underscoring the need to investigate the tick‐borne virome composition in such areas. In this study, metatranscriptomic analysis of five tick species, namely Haemaphysalis longicornis,
Zhe Liu, Shengwei Ji, Jinqi Wang, Yuan Li, Eloiza May Galon, Shanshan Wang, Jixu Li, Xu Gao, Longzheng Yu, Yang Wang, Jianchen Song, Qichao Cui, Chenghui Li, Zhiqiang Xu, Shujiang Xue, Kamani Joshua   +15 more
wiley   +1 more source

Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy [PDF]

Clinical and Molecular Hepatology
Background/Aims Chronic hepatitis C (CHC) patients who failed antiviral therapy are at increased risk for hepatocellular carcinoma (HCC). This study assessed the potential role of metformin and statins, medications for diabetes mellitus (DM) and ...
Pei-Chien Tsai, Chung-Feng Huang, Ming-Lun Yeh, Meng-Hsuan Hsieh, Hsing-Tao Kuo, Chao-Hung Hung, Kuo-Chih Tseng, Hsueh-Chou Lai, Cheng-Yuan Peng, Jing-Houng Wang, Jyh-Jou Chen, Pei-Lun Lee, Rong-Nan Chien, Chi-Chieh Yang, Gin-Ho Lo, Jia-Horng Kao, Chun-Jen Liu, Chen-Hua Liu, Sheng-Lei Yan, Chun-Yen Lin, Wei-Wen Su, Cheng-Hsin Chu, Chih-Jen Chen, Shui-Yi Tung, Chi‐Ming Tai, Chih-Wen Lin, Ching-Chu Lo, Pin-Nan Cheng, Yen-Cheng Chiu, Chia-Chi Wang, Jin-Shiung Cheng, Wei-Lun Tsai, Han-Chieh Lin, Yi-Hsiang Huang, Chi-Yi Chen, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chung, Ming-Jong Bair, Ming-Lung Yu, T-COACH Study Group   +40 more
doaj   +1 more source

Reconstruction of the historic time course of blood‐borne virus contamination of clotting factor concentrates, 1974–1992

Journal of Medical Virology, Volume 96, Issue 7, July 2024.
Abstract Factor VIII and IX clotting factor concentrates manufactured from pooled plasma have been identified as potent sources of virus infection in persons with hemophilia (PWHs) in the 1970s and 1980s. To investigate the range and diversity of viruses over this period, we analysed 24 clotting factor concentrates for several blood‐borne viruses ...
C. Patrick McClure, Kai Kean, Kaitlin Reid, Richard Mayne, Michael X. Fu, Piya Rajendra, Shannah Gates, Judy Breuer, Heli Harvala, Tanya Golubchik, Alexander W. Tarr, William L. Irving, Michael Makris, Peter Simmonds   +13 more
wiley   +1 more source

Natural reservoirs for homologs of hepatitis C virus

Emerging Microbes and Infections, 2014
Hepatitis C virus is considered a major public health problem, infecting 2%–3% of the human population. Hepatitis C virus infection causes acute and chronic liver disease, including chronic hepatitis, cirrhosis and hepatocellular carcinoma.
Stephanie Pfaender, Richard JP Brown, Thomas Pietschmann, Eike Steinmann   +3 more
doaj   +1 more source

Improving the safety of CAR‐T‐cell therapy: The risk and prevention of viral infection for patients with relapsed or refractory B‐cell lymphoma undergoing CAR‐T‐cell therapy

American Journal of Hematology, Volume 99, Issue 4, Page 662-678, April 2024.
Risk factors and prevention recommendations for viral infections in CAR T‐cell therapy. Abstract Chimeric antigen receptor (CAR) T‐cell therapy, an innovative immunotherapeutic against relapsed/refractory B‐cell lymphoma, faces challenges due to frequent viral infections.
Hu Qian, Xingcheng Yang, Tingting Zhang, Ping Zou, Yicheng Zhang, Weiwei Tian, Zekai Mao, Jia Wei   +7 more
wiley   +1 more source

Simeprevir-Based Triple Therapy with Reduced Doses of Pegylated Interferon α-2a Plus Ribavirin for Interferon Ineligible Patients with Genotype 1b Hepatitis C Virus

Gut and Liver, 2017
Background/AimsThe present study aimed to evaluate the safety and efficacy of simeprevir-based triple therapy with reduced doses of pegylated interferon (PEG-IFN) and ribavirin for interferon (IFN) ineligible patients, such as elderly and/or cirrhotic ...
Hideyuki Tamai, Yoshiyuki Ida, Akira Kawashima, Naoki Shingaki, Ryo Shimizu, Kosaku Moribata, Tetsushi Nasu, Takao Maekita, Mikitaka Iguchi, Jun Kato, Taisei Nakao, Masayuki Kitano   +11 more
doaj   +1 more source

Low-Dose Pegylated Interferon α-2b Plus Ribavirin for Elderly and/or Cirrhotic Patients with Genotype 2 Hepatitis C Virus

Gut and Liver, 2016
Background/AimsThis study aimed to predict sustained viral response (SVR) to low-dose pegylated interferon (PEG-IFN) plus ribavirin of elderly and/or cirrhotic patients with genotype 2 hepatitis C virus (HCV) using viral response within 2 weeks.Methods :
Hideyuki Tamai, Naoki Shingaki, Yoshiyuki Mori, Kosaku Moribata, Akira Kawashima, Yoshimasa Maeda, Toru Niwa, Hisanobu Deguchi, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Jun Kato, Masao Ichinose   +12 more
doaj   +1 more source

Design and nonviral delivery of live attenuated vaccine to prevent chronic hepatitis C virus-like infection

Nature Communications
An effective vaccine for the hepatitis C virus (HCV) remains an unmet medical need. There is no animal model for assessing HCV vaccines; however, rodent hepacivirus (RHV) infection in laboratory rats recapitulates the lifelong chronic hepatotropic ...
Sheetal Trivedi, Piyush Dravid, Tim C. Passchier, Satyapramod Murthy, Kripa Shanker Kasudhan, Narendran Reguraman, Justin Kellar, Rahul Chandra, Cole Cassady, Peter D. Burbelo, Arash Grakoui, Himanshu Sharma, Peter Simmonds, Amit Kapoor   +13 more
doaj   +1 more source