Results 201 to 210 of about 20,897 (221)
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Alzheimer s disease and heparan sulfate proteoglycan
Frontiers in Bioscience, 1998Alzheimer's disease (AD) is a debilitating neurodegenerative disorder. Cardinal histopathologic changes of AD are neurofibrillary tangles (NFTs) and deposits of beta-amyloid protein (A-beta) in the form of neuritic plaques (NPs). Several different mutations found in patients with familial AD have been demonstrated to increase A-beta production ...
Ling Li, M. Hart, Ken-ichiro Fukuchi
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Heparan Sulfate Proteoglycans in Amyloidosis
2010Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may be functionally involved in the ...
Xiao Zhang, Jin-Ping Li
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Binding of Rat Thyroglobulin to Heparan Sulfate Proteoglycans
Thyroid, 2000We previously showed that rat thyroglobulin (Tg) is a heparin-binding protein and that heparin inhibits Tg binding to megalin (gp330), an endocytic Tg receptor found on the apical surface of thyrocytes. Cooperation between cell surface receptors and heparin-like molecules, namely heparan sulfate proteoglycans (HSPGs), can facilitate cell surface ...
MARINO', MICHELE +2 more
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Integral membrane heparan sulfate proteoglycans
The FASEB Journal, 1993Heparan sulfate is a regulatory polysaccharide. It modulates specific growth factor-receptor interactions, accelerates the formation of specific proteinase-proteinase inhibitor complexes, and mediates interactions of the cell surface with several enzymes and structural proteins.
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Heparan sulfate proteoglycans in invasion and metastasis
Seminars in Cell & Developmental Biology, 2001Because heparan sulfate proteoglycans mediate cell adhesion and control the activities of numerous growth and motility factors, they play a critical role in regulating the metastatic behavior of tumor cells. Due to their utilitarian nature, heparan sulfate proteoglycans may at times act as inhibitors of cell invasion and at other times as promoters of ...
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Alterations of Heparan Sulfate Proteoglycans in Cancer [PDF]
Journal of Glycobiology, 2015 Heparan sulfate proteoglycans (HSPGs) are glycoproteins, with the common characteristic of containing covalently attached heparan sulfate glycosaminoglycan chains (GAGs). These molecules are highly modified in cancer, contributing to tumorigenesis.
Sonia Castañón +4 more
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Structural Properties of the Heparan Sulfate Proteoglycans of Brain
Journal of Neurochemistry, 1989Abstract: The heparan sulfate proteoglycans present in a deoxycholate extract of rat brain were purified by ion exchange chromatography, affinity chromatography on lipoprotein lipase agarose, and gel filtration. Heparitinase treatment of the heparan sulfate proteoglycan fraction (containing 86% heparan sulfate and 10% chondroitin sulfate) that was ...
Richard U. Margolis, James A. Ripellino
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Functions of Cell Surface Heparan Sulfate Proteoglycans
Annual Review of Biochemistry, 1999▪ Abstract The heparan sulfate on the surface of all adherent cells modulates the actions of a large number of extracellular ligands. Members of both cell surface heparan sulfate proteoglycan families, the transmembrane syndecans and the glycosylphosphoinositide-linked glypicans, bind these ligands and enhance formation of their receptor-signaling ...
Masahiro Zako +6 more
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Heparan sulfate proteoglycans and the emergence of neuronal connectivity
Current Opinion in Neurobiology, 2006With the identification of the molecular determinants of neuronal connectivity, our understanding of the extracellular information that controls axon guidance and synapse formation has evolved from single factors towards the complexity that neurons face in a living organism.
David Van Vactor +2 more
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Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans [PDF]
Glycobiology, 2001 Heparanases are endoglycosidases that cleave the heparan sulfate glycosaminoglycans from proteoglycan core proteins and degrade them to small oligosaccharides. Inside cells, these enzymes are important for the normal catabolism of heparan sulfate proteoglycans (HSPGs), generating glycosaminoglycan fragments that are then transported to lysosomes and ...
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