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Integral membrane heparan sulfate proteoglycans
The FASEB Journal, 1993Heparan sulfate is a regulatory polysaccharide. It modulates specific growth factor‐receptor interactions, accelerates the formation of specific proteinase‐proteinase inhibitor complexes, and mediates interactions of the cell surface with several enzymes and structural proteins.
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Heparan sulfate proteoglycans in healthy and diseased systems
WIREs Systems Biology and Medicine, 2011AbstractHeparin and heparan sulfate (HS) are glycosaminoglycans (GAGs) that are synthesized in the tissues and organs of mammals. They are synthesized and attached to a core protein as proteoglycans through serine–glycine concensus motifs along the core protein.
John, Whitelock, James, Melrose
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Synthesis of heparan sulfate proteoglycans by the isolated glomerulus
Biochemistry and Cell Biology, 1988Incorporation of [35S]sulfate into newly synthesized macromolecules was studied in the isolated rat glomerulus and found to be linear between 6 and 24 h. When whole glomeruli were treated under conditions that dissociate proteoglycan aggregates, >90% of incorporated label was extracted.
D M, Templeton, M, Khatchatourian
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Heparan sulfate proteoglycans in extravasation
Frontiers in Bioscience, 2009Heparan sulfate proteoglycans (HSPGs) are glycoconjugates that are implicated in various biological processes including development, inflammation and repair, which is based on their capacity to bind and present several proteins via their carbohydrate side chains (glycosaminoglycans; GAGs). Well-known HSPGs include the family of syndecans and glypicans,
Celie, Johanna W. A. M. +2 more
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Heparan sulfate proteoglycans in Drosophila neuromuscular development
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017Heparan sulfate proteoglycans (HSPGs) are glycoconjugates bearing heparan sulfate (HS) chains covalently attached to core proteins, which are ubiquitously distributed on the cell surface and in the extracellular matrix. HSPGs interact with a number of molecules mainly through HS chains, which play critical roles in diverse physiological and disease ...
Keisuke, Kamimura, Nobuaki, Maeda
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Heparan Sulfate Proteoglycan-Mediated Polyamine Uptake
2011The polyamines are polycationic compounds essential for cellular proliferation and transformation. In addition to a well-defined biosynthesis pathway, polyamines are internalized into cells by as yet incompletely defined mechanisms. Numerous reports have shown that efficient polyamine uptake depends on the presence of polyanionic, cell surface ...
Johanna, Welch +3 more
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Heparan sulfate proteoglycans and the emergence of neuronal connectivity
Current Opinion in Neurobiology, 2006With the identification of the molecular determinants of neuronal connectivity, our understanding of the extracellular information that controls axon guidance and synapse formation has evolved from single factors towards the complexity that neurons face in a living organism.
David, Van Vactor +2 more
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Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans
Glycobiology, 2001Heparanases are endoglycosidases that cleave the heparan sulfate glycosaminoglycans from proteoglycan core proteins and degrade them to small oligosaccharides. Inside cells, these enzymes are important for the normal catabolism of heparan sulfate proteoglycans (HSPGs), generating glycosaminoglycan fragments that are then transported to lysosomes and ...
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Autoantibodies to heparan sulfate proteoglycans
Autoimmunity Reviews, 2002Yves, Renaudineau +4 more
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