Results 201 to 210 of about 255,399 (229)
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Heparan Sulfate Proteoglycans in Diabetes
Seminars in Thrombosis and Hemostasis, 2021AbstractDiabetes is a complex disorder responsible for the mortality and morbidity of millions of individuals worldwide. Although many approaches have been used to understand and treat diabetes, the role of proteoglycans, in particular heparan sulfate proteoglycans (HSPGs), has only recently received attention.
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Heparan Sulfate Proteoglycans in Amyloidosis
2010Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may be functionally involved in the ...
Xiao, Zhang, Jin-Ping, Li
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Development of Molecules Antagonizing Heparan Sulfate Proteoglycans
Seminars in Thrombosis and Hemostasis, 2021AbstractHeparan sulfate proteoglycans (HSPGs) occur in almost every tissue of the human body and consist of a protein core, with covalently attached glycosaminoglycan polysaccharide chains. These glycosaminoglycans are characterized by their polyanionic nature, due to sulfate and carboxyl groups, which are distributed along the chain.
Tanja, Gerlza +4 more
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1999
Abstract Heparan sulfate proteoglycans (HSPGs)1 are highly charged macromolecules consisting of different core proteins with covalently linked heparan sulfate chains (HS) of varying monosaccharide sequence. These molecules are involved in a multitude of biologic processes including regulation of mesoderm induction, extension of neurites,
Nicholas W Shworak, Robert D Rosenberg
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Abstract Heparan sulfate proteoglycans (HSPGs)1 are highly charged macromolecules consisting of different core proteins with covalently linked heparan sulfate chains (HS) of varying monosaccharide sequence. These molecules are involved in a multitude of biologic processes including regulation of mesoderm induction, extension of neurites,
Nicholas W Shworak, Robert D Rosenberg
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Binding of Rat Thyroglobulin to Heparan Sulfate Proteoglycans
Thyroid, 2000We previously showed that rat thyroglobulin (Tg) is a heparin-binding protein and that heparin inhibits Tg binding to megalin (gp330), an endocytic Tg receptor found on the apical surface of thyrocytes. Cooperation between cell surface receptors and heparin-like molecules, namely heparan sulfate proteoglycans (HSPGs), can facilitate cell surface ...
MARINO', MICHELE +2 more
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Alzheimer s disease and heparan sulfate proteoglycan
Frontiers in Bioscience, 1998Alzheimer's disease (AD) is a debilitating neurodegenerative disorder. Cardinal histopathologic changes of AD are neurofibrillary tangles (NFTs) and deposits of beta-amyloid protein (A-beta) in the form of neuritic plaques (NPs). Several different mutations found in patients with familial AD have been demonstrated to increase A-beta production ...
K, Fukuchi, M, Hart, L, Li
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Structural Properties of the Heparan Sulfate Proteoglycans of Brain
Journal of Neurochemistry, 1989Abstract: The heparan sulfate proteoglycans present in a deoxycholate extract of rat brain were purified by ion exchange chromatography, affinity chromatography on lipoprotein lipase agarose, and gel filtration. Heparitinase treatment of the heparan sulfate proteoglycan fraction (containing 86% heparan sulfate and 10% chondroitin sulfate) that was ...
J A, Ripellino, R U, Margolis
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Integral membrane heparan sulfate proteoglycans
The FASEB Journal, 1993Heparan sulfate is a regulatory polysaccharide. It modulates specific growth factor‐receptor interactions, accelerates the formation of specific proteinase‐proteinase inhibitor complexes, and mediates interactions of the cell surface with several enzymes and structural proteins.
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Heparan sulfate proteoglycans in healthy and diseased systems
WIREs Systems Biology and Medicine, 2011AbstractHeparin and heparan sulfate (HS) are glycosaminoglycans (GAGs) that are synthesized in the tissues and organs of mammals. They are synthesized and attached to a core protein as proteoglycans through serine–glycine concensus motifs along the core protein.
John, Whitelock, James, Melrose
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Synthesis of heparan sulfate proteoglycans by the isolated glomerulus
Biochemistry and Cell Biology, 1988Incorporation of [35S]sulfate into newly synthesized macromolecules was studied in the isolated rat glomerulus and found to be linear between 6 and 24 h. When whole glomeruli were treated under conditions that dissociate proteoglycan aggregates, >90% of incorporated label was extracted.
D M, Templeton, M, Khatchatourian
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