Results 71 to 80 of about 20,897 (221)

Heparanase: A Novel Therapeutic Target for the Treatment of Atherosclerosis

Cells, 2022
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and its management places a huge burden on healthcare systems through hospitalisation and treatment.
Tien K. Nguyen, Stephanie Paone, Enoch Chan, Ivan K. H. Poon, Amy A. Baxter, Shane R. Thomas, Mark D. Hulett   +6 more
doaj   +1 more source

Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications

ChemBioChem, EarlyView.
Glycosaminoglycans (GAGs) are linear, anionic biopolymers with their functions tightly linked to their charge. This review approaches GAGs from a polyelectrolyte perspective, shedding light on how the distribution of sulfate groups and, thus, negative charges, governs their interactions with other biomolecules.
Gergo Peter Szekeres, Eunjin Moon, Johanna K. Elter, Bryce Roper, Jayachandran Narayanan Nair Kizhakkedathu, Matthias Ballauff, Rainer Haag, Kevin Pagel   +7 more
wiley   +1 more source

Regulation of stem cell fate by HSPGs: implication in hair follicle cycling

npj Regenerative Medicine, 2022
Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein.
Charlie Colin-Pierre, Oussama El Baraka, Louis Danoux, Vincent Bardey, Valérie André, Laurent Ramont, Stéphane Brézillon   +6 more
doaj   +1 more source

Establishment, Characterization, and Cryopreservation of Feather Follicle Fibroblast Lines From Hyacinth Macaw (Anodorhynchus hyacinthinus)

Cell Biology International, EarlyView.
ABSTRACT Cryopreservation, biobanking, and in vitro propagation of cells from endangered species represent key strategies for advancing biodiversity conservation. The Hyacinth Macaw (Anodorhynchus hyacinthinus), a flagship avian species of the Brazilian Pantanal, is among the critically vulnerable taxa that stand to benefit significantly from such ...
Iara Pastor Martins Nogueira, Rachel Castro Teixeira‐Santos, Gustavo Caldeira Cotta, Wanderson Valente, John Lennon Paiva de Coimbra, Heloísa Athaydes Seabra Ferreira, Pedro Pires Goulart Guimarães, Anderson Kenedy Santos, Fernanda Mussi Fontoura, Kefany Rodrigues de Andrade Ramalho, Neiva Maria Robaldo Guedes, Samyra Maria dos Santos Nassif Lacerda   +11 more
wiley   +1 more source

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Glycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for β3GalT6‐deficient spondylodysplastic Ehlers–Danlos syndrome

JIMD Reports, 2022
The spondylodysplastic type of Ehlers–Danlos syndrome (spEDS) is caused by genetic defects in the B4GALT7 or B3GALT6 genes both deranging the biosynthesis of the glycosaminoglycan linkage region of chondroitin/dermatan sulfate and heparan sulfate ...
Mahnaz Nikpour, Fredrik Noborn, Jonas Nilsson, Tim Van Damme, Olivier Kaye, Delfien Syx, Fransiska Malfait, Göran Larson   +7 more
doaj   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index

Molecular Nutrition &Food Research, EarlyView.
We analyzed colostrum and breast milk from 47 mothers to see how proteins change over time and with maternal health. Colostrum had more immune proteins, while mature milk had proteins linked to growth support. Gestational diabetes and higher BMI altered the protein composition.
Timo Seitz, Jenni Viitaharju, Chouaib Benchraka, Johannes Merilahti, Marko Kalliomäki, Lauri Polari, Diana Toivola, Leo Lahti, Otto Kauko, Kirsi Laitinen   +9 more
wiley   +1 more source

Role of Heparan Sulfate 2-O-Sulfotransferase in Prostate Cancer Cell Proliferation, Invasion, and Growth Factor Signaling

Prostate Cancer, 2011
Heparan-sulfate proteoglycans (HSPGs) are required for maximal growth factor signaling in prostate cancer progression. The degree of sulfate modification on the covalently attached heparan sulfate (HS) chains is one of the determining factors of growth ...
Brent W. Ferguson, Sumana Datta
doaj   +1 more source

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

Neuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai, Qing Nan, Menglu Xu, Hongbao Li   +3 more
wiley   +1 more source