Results 91 to 100 of about 39,579 (251)

The endothelial glycocalyx: composition, functions, and visualization [PDF]

, 2007
This review aims at presenting state-of-the-art knowledge on the composition and functions of the endothelial glycocalyx. The endothelial glycocalyx is a network of membrane-bound proteoglycans and glycoproteins, covering the endothelium luminally.
Sietze Reitsma, Dick W. Slaaf, Hans Vink, Marc A. M. J. van Zandvoort, Mirjam G. A. oude Egbrink, P Algenstaedt, S Ali, BL Allen, ML Ballinger, AL Barker, A Beresewicz, MC Berndt, RJ Beuk, L Bode, L Bode, T Bombeli, DJ Carey, AA Constantinescu, FR Curry, S Das, PF Davies, C Desjardins, CF Dewey Jr, VS Dole, XL Du, MG Egbrink, JD Esko, SP Evanko, JA Florian, LA Fransson, JR Fromm, JL Funderburgh, L Ghitescu, RM Gibson, M Gouverneur, N Grammatikakis, DN Granger, YF Han, GK Hansson, CB Henry, CB Henry, C Hjalmarsson, G Ho, AJ Hoogewerf, X Hu, MT Huang, VH Huxley, NS Ihrcke, RV Iozzo, M Jacob, GH Janssen, U Jung, GS Kansas, H Kato, MG Kinsella, B Klitzman, B Klitzman, JA Koedam, H Kresse, AM Kupinski, I Kurose, TC Laurent, JY Lee, Q Li, P Libby, X Lin, HH Lipowsky, HH Lipowsky, F Lopez-Casillas, JA Lopez, JH Luft, RTA Megens, CC Michel, S Mochizuki, AW Mulivor, AM Muller, A Nandi, DM Nathan, M Nieuwdorp, M Nieuwdorp, M Nieuwdorp, MG Oliver, MG oude Egbrink, JR Pappenheimer, KA Parker, KD Patel, N Perrimon, AR Pries, AR Pries, AR Pries, AR Pries, NS Quinsey, R Raman, A Rapraeger, A Rapraeger, M Rehm, CJ Robinson, R Ross, J Rostgaard, J Rostgaard, GM Rubanyi, I Rubio-Gayosso, C Ruegg, ZM Ruggeri, S Salek-Ardakani, IH Sarelius, K Sasaki, JE Scott, JE Scott, JB Seal, TW Secomb, K Shimada, M Sperandio, M Sperandio, D Spillmann, TA Springer, EH Starling, RJ Stewart, K Sugahara, L Tan, JM Tarbell, JM Tarbell, LM Title, E Tkachenko, AM Tovar, A Ueda, B Berg van den, BM Berg van den, BM Berg van den, PM Haaren van, PM Haaren van, M Zandvoort van, H Vink, H Vink, H Vink, CA Vogl-Willis, B Vollmar, CS Wang, BJ Ward, PH Weigel, H Weiler, S Weinbaum, S Weinbaum, W Weninger, LC Wilsie, G Wu, JP Xiong, K Yamashita, X Zhang, L Zhuo   +149 more
core   +1 more source

Controlled Triazine‐Based Covalent Functionalization of Black Phosphorus for Degradable Hybrid Materials

Small, EarlyView.
A scalable triazine‐based covalent functionalization strategy of black phosphorus nanosheets provides controlled P‐N surface chemistry with enhanced grafting density in the presence of a phase‐transfer catalyst. As a representative example, BP‐sulfated polymer conjugates exhibit strong in vitro antiviral activity against enveloped viruses and ...
Jasmin Er, Sreejita Ray, Enyu Xie, Robert Schusterbauer, Maik Rosentreter, Ranen Etouki, Na Xing, Anja Wiesner, Philip Nickl, Rameez Ahmed, Taylor Page, Ana Hočevar, Obida Bawadkji, Andreas Herrmann, Jörg Radnik, Vasile‐Dan Hodoroaba, Christian Sieben, Beate Paulus, Ievgen S. Donskyi   +18 more
wiley   +1 more source

Heparan sulfate proteoglycans regulate autophagy in Drosophila [PDF]

Autophagy, 2017
Heparan sulfate-modified proteoglycans (HSPGs) are important regulators of signaling and molecular recognition at the cell surface and in the extracellular space. Disruption of HSPG core proteins, HS-synthesis, or HS-degradation can have profound effects on growth, patterning, and cell survival.
Reynolds-Peterson, Claire E., Zhao, Na, Xu, Jie, Serman, Taryn M., Xu, Jielin, Selleck, Scott B.   +5 more
openaire   +2 more sources

Proteinase activity regulation by glycosaminoglycans [PDF]

, 2002
There are few reports concerning the biological role and the mechanisms of interaction between proteinases and carbohydrates other than those involved in clotting. It has been shown that the interplay of enzymes and glycosaminoglycans is able to modulate
Almeida, P.c., Chagas, Jair Ribeiro, Pimenta, D.c., Tersariol, Ivarne Luis dos Santos   +3 more
core   +3 more sources

Alteration in oral and non‐oral tissues in ligature‐induced periodontitis mice with the Alzheimer's disease risk factor APOE4

European Journal of Oral Sciences, EarlyView.
Abstract The APOE4 gene, particularly the ε4 allele, is linked to susceptibility to Alzheimer's disease, and periodontitis can cause pathological changes in multiple organs, but combined effects of these conditions and the impact of tumor necrosis factor (TNF)‐α regulation on the combined effects remain unclear.
Ae Ri Kim, Yun‐Jung Yoo, Eun‐Jung Bak   +2 more
wiley   +1 more source

Chemical Tumor Biology of Heparan Sulfate Proteoglycans [PDF]

Current Chemical Biology, 2010
Heparan sulfate proteoglycans (HSPGs) play vital roles in every step of tumor progression allowing cancer cells to proliferate, escape from immune response, invade neighboring tissues, and metastasize to distal sites away from the primary site. Several cancers including breast, lung, brain, pancreatic, skin, and colorectal cancers show aberrant ...
Karthik, Raman, Balagurunathan, Kuberan
openaire   +2 more sources

Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids.

PLoS ONE, 2012
BackgroundStromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. Heparan sulfate proteoglycans, present both
Cecilia Österholm, Ning Lu, Åsa Lidén, Tine V Karlsen, Donald Gullberg, Rolf K Reed, Marion Kusche-Gullberg   +6 more
doaj   +1 more source

Inhibition of Heparan Sulfate and Chondroitin Sulfate Proteoglycan Biosynthesis [PDF]

Journal of Biological Chemistry, 2008
Proteoglycans (PGs) are composed of a protein moiety and a complex glycosaminoglycan (GAG) polysaccharide moiety. GAG chains are responsible for various biological activities. GAG chains are covalently attached to serine residues of the core protein. The first step in PG biosynthesis is xylosylation of certain serine residues of the core protein.
Dinesh R, Garud, Vy M, Tran, Xylophone V, Victor, Mamoru, Koketsu, Balagurunathan, Kuberan   +4 more
openaire   +2 more sources

Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis [PDF]

, 2014
Background Heparan sulfate proteoglycans (HSPG) are important for embryonic development via the regulation of gradient formation and signaling of multiple growth factors and morphogens.
Cai, Zhigang, Grobe, Kay, Zhang, Xin
core   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source