Results 111 to 120 of about 39,579 (251)

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.
ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells [PDF]

, 2009
Background Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane.
Bodil Fadnes, Øystein Rekdal, Lars Uhlin-Hansen, HG Boman, D Hultmark, B Cornet, ZQ Li, B Bechinger, IV Polozov, LT Eliassen, LT Eliassen, N Papo, Y Chen, SR Dennison, JS Mader, SA Johnstone, RA Cruciani, Y Ohsaki, S Kim, K Matsuzaki, Y Pouny, Z Oren, HM Ellerby, MR Yeaman, T Utsugi, CD Bucana, M Sugimura, LV Rao, YJ Kim, DH Dube, L Kjellen, K Sugahara, E Tkachenko, DL Rabenstein, F Zsila, J Kleeff, K Matsuda, RD Sanderson, GC Jayson, F Safaiyan, JS Mader, YC Yoo, H Jenssen, JD Esko, X Bai, LT Eliassen, KM Keller, M Yanagishita, JE Shively, H Greve, L Uhlin-Hansen, SE Stringer, A Risso, H Schroder-Borm, CD Klaassen, F Safaiyan, L Zhang, TF Smetsers, A Molist, GH Guibinga, M Ueda, M Bernfield, LA Fransson, S Tumova, SG Rees, A Schmidtchen, W Baranska-Rybak, A Schmidtchen, H Jenssen, JH Andersen, A Roseanu, S Ashikari-Hada, Y Yuguchi, M Kusche, Y Mahalingam, M Rintala, K Harada, H Kurokawa, K Bame, N Ilan   +79 more
core   +3 more sources

Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan [PDF]

, 2020
Zehra Elgundi, Michael Papanicolaou, Gretel S. Major, Thomas R. Cox, James Melrose, John M. Whitelock, Brooke L. Farrugia   +6 more
openalex   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, Volume 36, Issue 3, May 2026.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Mechanisms of cell entry by human papillomaviruses: an overview [PDF]

, 2010
peer reviewedABSTRACT: As the primary etiological agents of cervical cancer, human papillomaviruses (HPVs) must deliver their genetic material into the nucleus of the target cell.
Caroline AJ Horvath, Gaëlle AV Boulet, Virginie M Renoux, Philippe O Delvenne, John-Paul J Bogers   +4 more
core   +2 more sources

Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans.

PLoS Genetics, 2017
The regulation of cell migration is essential to animal development and physiology. Heparan sulfate proteoglycans shape the interactions of morphogens and guidance cues with their respective receptors to elicit appropriate cellular responses.
Cassandra R Blanchette, Andrea Thackeray, Paola N Perrat, Siegfried Hekimi, Claire Y Bénard   +4 more
doaj   +1 more source

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

Nature Communications, 2017
PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation.
Camilla Gustafsen, Ditte Olsen, Joachim Vilstrup, Signe Lund, Anika Reinhardt, Niels Wellner, Torben Larsen, Christian B. F. Andersen, Kathrin Weyer, Jin-ping Li, Peter H. Seeberger, Søren Thirup, Peder Madsen, Simon Glerup   +13 more
doaj   +1 more source

Regulation of heparanase expression in coronary artery disease in diabetic, hyperlipidemic swine [PDF]

, 2010
Objective Enzymatic degradation of the extracellular matrix is known to be powerful regulator of atherosclerosis. However, little is known about the enzymatic regulation of heparan sulfate proteoglycans (HSPGs) during the formation and progression of ...
Baker, Aaron B., Beigel, Roy, Chatzizisis, Ioannis, Chatzizisis, Yiannis S., Coskun, Ahmet U., Edelman, Elazer R., Feldman, Charles L., Jonas, Michael, Koskinas, Konstantinos C., Maynard, Charles, Rogers, Campbell, Stone, Benjamin V., Stone, Peter H.   +12 more
core   +1 more source

Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity

Frontiers in Molecular Neuroscience, 2018
Neural circuits consist of distinct neuronal cell types connected in specific patterns. The specificity of these connections is achieved in a series of sequential developmental steps that involve the targeting of neurites, the identification of synaptic ...
Giuseppe Condomitti, Giuseppe Condomitti, Joris de Wit, Joris de Wit   +3 more
doaj   +1 more source

Intra-articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate [PDF]

, 2010
Objective: Insulin-like growth factor 1 (IGF-1) stimulates cartilage repair but is not a practical therapy due to its short half-life. We have previously modified IGF-1 by adding a heparin-binding domain and have shown that this fusion protein (HB-IGF-1)
Cole, Ada A., Cummings, Kiersten, Grodzinsky, Alan J., Lee, Richard T., Miller, Rachel Elizabeth, Patwari, Parth, Plaas, Anna H. K.   +6 more
core   +1 more source