Results 131 to 140 of about 255,399 (229)

Heparan sulfate proteoglycans in cancer: Pathogenesis and therapeutic potential. [PDF]

Adv Cancer Res, 2023
Yang H, Wang L.
europepmc   +1 more source

Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Hypertension is a highly prevalent clinical condition and a major contributor to global cardiovascular morbidity and mortality. Despite extensive research, its complex and multifaceted pathogenesis is yet to be fully elucidated. This paper explores the updated understanding of primary hypertension as a systemic disorder rather than an isolated
Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H. Eid   +5 more
wiley   +1 more source

Regulation of autophagy, lipid metabolism, and neurodegenerative pathology by heparan sulfate proteoglycans. [PDF]

Front Genet, 2022
Schultheis N, Becker R, Berhanu G, Kapral A, Roseman M, Shah S, Connell A, Selleck S.   +7 more
europepmc   +1 more source

Heparin Can Augment Extracellular Vesicle Yield by Inhibiting Reuptake in Donor Cells During Cell Propagation

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Heparin augments EV yield in culture by inhibiting EV binding to cell‐surface HSPG and masking EV surface. Preventing autocrine and homotypic paracrine EV uptake during cell culture results in EV accumulation and higher yield. Heparin improved EV recovery after storage in NaCl but not in complex media or protein‐rich buffer(Please see Figure 9 for ...
André Cronemberger Andrade, Rodolphe Poupardin, Martin Wolf, Liliia Paniushkina, Karim Selmi, Deepika Kundully Suresh, Nicole Maeding, Heide‐Marie Binder, Janine Zwicklhuber, Sarah Hochmann, André Görgens, Samir El Andaloussi, Katharina Schallmoser, Dirk Strunk   +13 more
wiley   +1 more source

Importance of Heparan Sulfate Proteoglycans in Pancreatic Islets and β-Cells. [PDF]

Int J Mol Sci, 2022
Takahashi I.
europepmc   +1 more source

Heparan sulfate-binding peptide promotes the deposition of proteoglycans in the extracellular matrix

, 1997
A synthetic peptide, which was shown to bind extracellular matrix heparan sulfate chains with a high degree of affinity and specificity [Colburn el al.
Kobayashi, E., Buonassisi, V, Colburn, P.   +2 more
core   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans. [PDF]

Cancers (Basel), 2023
Hassan N, Efing J, Kiesel L, Bendas G, Götte M.   +4 more
europepmc   +1 more source

Carbon Quantum Dots: From Mechanisms to Biomedical Applications

MedComm, Volume 7, Issue 10, October 2026.
Carbon quantum dots (CQDs) are promising carbon‐based nanomaterials with broad biomedical applications, including bioimaging, drug delivery, biosensing, and tissue regeneration. This Review summarizes the biological mechanisms of CQDs in tissue regeneration, focusing on their regulation of cellular functions, immune responses, and redox balance.
Bingxin Fan, Nianqiang Jin, Nuo Jin, Jiayu Shen, Xinliang Duan, Sichen Han, Yao Yuan, Zilin Wang   +7 more
wiley   +1 more source

Bioinformatics analysis identifies heparan sulfate proteoglycans acting as different progress subtypes of biliary atresia. [PDF]

Front Pediatr, 2023
Ding Z, Song W, Zhu W, Xie H, Zhu Z, Tang W.   +5 more
europepmc   +1 more source