Results 131 to 140 of about 239,929 (209)

Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis

Nature Communications
Convergence and extension (C&E) cell movements that elongate the primary embryonic axis are precisely timed during vertebrate gastrulation, but mechanisms controlling their onset remain unknown.
Ailen Soledad Cervino, Amrita Basu, Ryan J. Weiss, Gursimran Kaur Bajwa, Rubén Marín-Juez, Sandra L. Grimm, Cristian Coarfa, Margot Kossmann Williams   +7 more
doaj   +1 more source

Heparan sulfate proteoglycans in cancer: Pathogenesis and therapeutic potential. [PDF]

Adv Cancer Res, 2023
Yang H, Wang L.
europepmc   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Regulation of autophagy, lipid metabolism, and neurodegenerative pathology by heparan sulfate proteoglycans. [PDF]

Front Genet, 2022
Schultheis N, Becker R, Berhanu G, Kapral A, Roseman M, Shah S, Connell A, Selleck S.   +7 more
europepmc   +1 more source

Angiopoietin‐like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride‐rich lipoproteins in humans

Journal of Internal Medicine, Volume 300, Issue 3, Page 312-328, September 2026.
Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Marcello Arca, Elias Björnson, Laura D'Erasmo, Alessia Di Costanzo, Simone Bini, Ilenia Minicocci, Daniele Tramontano, Stella Covino, Giuseppe Ciarlo, Manuela Lombardi, Sanni Söderlund, Niina Matikainen, Linda Andersson, Martin Adiels, Marja‐Riitta Taskinen, Chris J. Packard, Jan Borén   +16 more
wiley   +1 more source

Importance of Heparan Sulfate Proteoglycans in Pancreatic Islets and β-Cells. [PDF]

Int J Mol Sci, 2022
Takahashi I.
europepmc   +1 more source

The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans. [PDF]

Cancers (Basel), 2023
Hassan N, Efing J, Kiesel L, Bendas G, Götte M.   +4 more
europepmc   +1 more source

Bioinformatics analysis identifies heparan sulfate proteoglycans acting as different progress subtypes of biliary atresia. [PDF]

Front Pediatr, 2023
Ding Z, Song W, Zhu W, Xie H, Zhu Z, Tang W.   +5 more
europepmc   +1 more source

Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin

Viruses
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells.
Jiyuan Yang, Yuefan Song, Weihua Jin, Ke Xia, Grace C. Burnett, Wanjin Qiao, John T. Bates, Vitor H. Pomin, Chunyu Wang, Mingqiang Qiao, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang   +12 more
doaj   +1 more source

The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates. [PDF]

BMC Mol Cell Biol, 2022
Ferreira A, Royaux I, Liu J, Wang Z, Su G, Moechars D, Callewaert N, De Muynck L.   +7 more
europepmc   +1 more source