Results 151 to 160 of about 23,189 (236)

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

MedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato   +5 more
wiley   +1 more source

Heparan sulfate proteoglycans mediate the invasion of cardiomyocytes by Trypanosoma cruzi

, 2003
Cytoadherence is an important step for the invasion of a mammalian host cell by Trypanosoma cruzi. Cell surface macromolecules are implicated in the T. cruzi-cardiomyocyte recognition process.
Calvet, C. M., MIRIAN CLAUDIA S. PEREIRA, De Meirelles, M. D., CLAUDIA M. CALVET, Toma, L., De Souza, F. R., LENY TOMA, MARIA DE NAZARETH S.L. DE MEIRELLES, Pereira, MCS, FERNANDA ROCHA DE SOUZA   +9 more
core   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson's in vivo models. [PDF]

Life Sci Alliance, 2022
Chen M, Vincent J, Ezeanii A, Wakade S, Yerigenahally S, Mor DE.   +5 more
europepmc   +1 more source

Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions.

, 2000
Udgivelsesdato: 2000-MarHeparan sulfate proteoglycans are complex molecules composed of a core protein with covalently attached glycosaminoglycan chains.
Couchman, J R, Tumova, S, Woods, A
core  

Heparanase inhibition prevents glycocalyx damage and albuminuria in experimental minimal change disease

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Michael Crompton, Raina D. Ramnath, Kai Betteridge, Sara Desideri, Aldara Martin Alonso, Lulu Jiang, Monica Gamez, Holly Stowell‐Connolly, Viktoriia Vasylchenko, Karen L. Onions, Matthew J. Butler, Chris R. Neal, Andrew H. J. Salmon, Jeremy E. Turnbull, Hiroshi Kawachi, Olga V. Zubkova, Gavin I. Welsh, Simon C. Satchell, Rebecca R. Foster   +18 more
wiley   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, Volume 3, Issue 2, June 2026.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

Pericellular heparan sulfate proteoglycans: Role in regulating the biosynthetic response of nucleus pulposus cells to osmotic loading. [PDF]

JOR Spine, 2022
Krull CM, Rife J, Klamer B, Purmessur D, Walter BA.   +4 more
europepmc   +1 more source

Heparan Sulfate and Chondroitin Sulfate Proteoglycans as Detectable Biomarkers in Alzheimer's Disease

, 2017
With the focus of researchers and physicians shifting from treating patients at late stages of neurodegeneration to creating longitudinal brain health records for early diagnosis, viable biomarkers for Alzheimer’s disease will be needed.
Iregbu, Obi
core  

Controlled Triazine‐Based Covalent Functionalization of Black Phosphorus for Degradable Hybrid Materials

Small, Volume 22, Issue 34, 17 June 2026.
A scalable triazine‐based covalent functionalization strategy of black phosphorus nanosheets provides controlled P‐N surface chemistry with enhanced grafting density in the presence of a phase‐transfer catalyst. As a representative example, BP‐sulfated polymer conjugates exhibit strong in vitro antiviral activity against enveloped viruses and ...
Jasmin Er, Sreejita Ray, Enyu Xie, Robert Schusterbauer, Maik Rosentreter, Ranen Etouki, Na Xing, Anja Wiesner, Philip Nickl, Rameez Ahmed, Taylor Page, Ana Hočevar, Obida Bawadkji, Andreas Herrmann, Jörg Radnik, Vasile‐Dan Hodoroaba, Christian Sieben, Beate Paulus, Ievgen S. Donskyi   +18 more
wiley   +1 more source