Results 141 to 150 of about 23,189 (236)

The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates. [PDF]

BMC Mol Cell Biol, 2022
Ferreira A, Royaux I, Liu J, Wang Z, Su G, Moechars D, Callewaert N, De Muynck L.   +7 more
europepmc   +1 more source

Heparanase‐Loaded CAR T Extracellular Vesicles Remodel the Colorectal Tumour Microenvironment and Boost T Cell Antitumor Immunity

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Dense ECM restricts CAR T efficacy in solid tumours. Zhu et al. design mesothelin‐targeted CAR T cells that secrete heparanase‐rich extracellular vesicles via a truncated hepatitis A virus pX domain (pX‐Δ1‐30), promoting ECM degradation, durable memory, and less exhausted phenotypes, leading to strong antitumor responses in colorectal cancer spheroids ...
Songshan Zhu, Jun Yin, Weiqiang Yang, Xin Fu, Yiwei Zeng, Na Huang, Ling Zhang, Cong Yu, Ping Ouyang, Kaisong Huang, Rui Chen, Xiaolei Zhao, Dan Jiang, Guangxian Xu   +13 more
wiley   +1 more source

Heparan sulfate-binding peptide promotes the deposition of proteoglycans in the extracellular matrix

, 1997
A synthetic peptide, which was shown to bind extracellular matrix heparan sulfate chains with a high degree of affinity and specificity [Colburn el al.
Kobayashi, E., Buonassisi, V, Colburn, P.   +2 more
core   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin

Viruses
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells.
Jiyuan Yang, Yuefan Song, Weihua Jin, Ke Xia, Grace C. Burnett, Wanjin Qiao, John T. Bates, Vitor H. Pomin, Chunyu Wang, Mingqiang Qiao, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang   +12 more
doaj   +1 more source

Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction. [PDF]

Viruses, 2022
Schröer K, Alshawabkeh M, Schellhorn S, Bronder K, Zhang W, Ehrhardt A.   +5 more
europepmc   +1 more source

From 2D to 3D Bioprinted In Vitro Breast Cancer Model: A Comparative Study of Proliferation, Tissue Structure, and mTOR Signaling

MedComm, Volume 7, Issue 6, June 2026.
A 3D bioprinted breast cancer model was created to more accurately reproduce in vivo tumor characteristics compared to conventional 2D cultures. Distinct cell adhesion patterns, reduced mTOR signaling, and altered drug responses were observed under 3D conditions.
Dorottya Moldvai, Gábor Petővári, Rebeka Gelencsér, Dániel Sztankovics, Risa Miyaura, Viktória Varga, Fatime Szalai, Kornélia Baghy, Ildikó Krencz, Titanilla Dankó, Anna Sebestyén   +10 more
wiley   +1 more source

An Atlas of Heparan Sulfate Proteoglycans in the Postnatal Rat Lens. [PDF]

Invest Ophthalmol Vis Sci, 2021
Wishart TFL, Lovicu FJ.
europepmc   +1 more source

In vivo turnover of the basement membrane and other heparan sulfate proteoglycans of rat glomerulus.

, 1989
Udgivelsesdato: 1989-MarThe metabolic turnover of rat glomerular proteoglycans in vivo was investigated. Newly synthesized proteoglycans were labeled during a 7-h period after injecting sodium [35S]sulfate intraperitoneally.
Beavan, L A, Davies, M, Couchman, J R, Williams, M A, Mason, R M   +4 more
core  

Heparan Sulfate proteoglycans, tumour progression and the cancer stem cell niche

, 2009
The cancer stem cell hypothesis states that tumours arise from cells with the ability to self-renew and differentiate into multiple cell types, and that these cells persist in tumors as a distinct population that can cause disease relapse and hence ...
Haupt, Larisa, Griffiths, Lyn R., Griffiths, Lyn, Haupt, Larisa M.   +3 more
core   +1 more source