Results 141 to 150 of about 255,399 (229)

A High‐Throughput SPR‐Based Array for Quantitative Profiling of Glycosaminoglycan–Protein Interactions

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Glycosaminoglycans (GAGs) are linear, negatively charged, polysaccharides that mediate a wide variety of biologically critical interactions with proteins, underpinning growth factor signaling, extracellular matrix assembly, and numerous disease processes.
Holly L. Birchenough, Jonathan F. Popplewell, H. Davies‐Strickleton, Douglas Dyer, Anthony J. Day, Thomas A. Jowitt   +5 more
wiley   +1 more source

Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin

Viruses
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells.
Jiyuan Yang, Yuefan Song, Weihua Jin, Ke Xia, Grace C. Burnett, Wanjin Qiao, John T. Bates, Vitor H. Pomin, Chunyu Wang, Mingqiang Qiao, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang   +12 more
doaj   +1 more source

Small Proteoglycans, Big Impact: Decorin, Biglycan, and Asporin in Musculoskeletal Tissue Health and Disease

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT The extracellular matrix (ECM) is a dynamic and information‐rich network that integrates structural support with biochemical and mechanical signaling. Among its key regulatory components are the Small Leucine‐Rich Proteoglycans (SLRPs), a family of matrix molecules that coordinate extracellular architecture with cell signaling.
Alessandra Leone, Zsuzsa Jenei‐Lanzl, Frank Zaucke   +2 more
wiley   +1 more source

The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates. [PDF]

BMC Mol Cell Biol, 2022
Ferreira A, Royaux I, Liu J, Wang Z, Su G, Moechars D, Callewaert N, De Muynck L.   +7 more
europepmc   +1 more source

Chemistry and biology of heparin and heparan sulfate /

, 2005
The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan
Garg, Hari G., Linhardt, Robert J., Hales, Charles A.   +2 more
core  

Proteoglycans and Lyme Disease: Molecular Interfaces in Adhesion, Tissue Tropism, and Therapeutic Discovery

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Lyme disease, caused by spirochetes of the Borrelia burgdorferi sensu lato complex, is a multisystem tick‐borne infection in which bacterial dissemination depends on interactions with host cells and the extracellular matrix (ECM). Proteoglycans (PGs), composed of core proteins modified with glycosaminoglycan (GAG) chains, are abundant and ...
Fuming Zhang, Ke Xia, Yi‐Pin Lin
wiley   +1 more source

Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction. [PDF]

Viruses, 2022
Schröer K, Alshawabkeh M, Schellhorn S, Bronder K, Zhang W, Ehrhardt A.   +5 more
europepmc   +1 more source

Laminin Expression and Function in the Central Nervous System

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Laminin, an extracellular matrix protein with multiple isoforms, is a key component of the basal lamina. In the central nervous system (CNS), different cells synthesize distinct laminin isoforms, which exert a diverse range of functions, including blood‐brain barrier maintenance/repair, cell survival/migration/differentiation, myelination ...
Lingling Xu, Sarah Yuan, Yao Yao
wiley   +1 more source

An Atlas of Heparan Sulfate Proteoglycans in the Postnatal Rat Lens. [PDF]

Invest Ophthalmol Vis Sci, 2021
Wishart TFL, Lovicu FJ.
europepmc   +1 more source

Circulating SCGB3A2 Is Associated With Impaired Coronary Collateralization in Patients With Chronic Total Occlusion and Type 2 Diabetes: A Proteomic Discovery and Validation Study

Journal of Diabetes, Volume 18, Issue 10, October 2026.
Proteomic profiling identified SCGB3A2 as a novel biomarker associated with impaired coronary collateralization in patients with chronic total occlusion and Type 2 diabetes. Independent validation supports its potential for risk stratification. ABSTRACT Background Type 2 diabetes mellitus (T2DM) is associated with impaired coronary collateralization in
Jian‐Jun Chen, Shuai Chen, Jia‐Kang Wang, Ke Huang, An Wang, Lin Lu, Yang Dai, Feng‐Hua Ding   +7 more
wiley   +1 more source