Results 121 to 130 of about 23,189 (236)

Heterogeneity of heparan sulfate proteoglycans synthesized by PYS-2 cells

, 1984
Antibodies to the basement membrane proteoglycan produced by the EHS tumor were used to immunoprecipitate [35S]sulfate-labeled protoglycans produced by PYS-2 cells.
Hassell, John R., Horigan, Elizabeth A., Klippenstein, Donald L., Tyree, Bernadette   +3 more
core  

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

An NMR and molecular modelling study on the solution conformation of Heparan Sulphate: new insights into the relationship between structure and function

, 2007
A deeper insight into the structural biology of HS is key to understanding its nearuniversal functional role as a co-receptor for growth factors and morphogens.
Murphy, K.J.
core  

A working model for CCN3 C‐terminal domain‐mediated transcriptional modulation of the plasminogen activation system

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Plasminogen is a circulating zymogen that is converted into active plasmin by plasminogen activators such as tissue plasminogen activator (tPA) and urokinase‐type PA (uPA). This conversion is regulated by plasminogen activator inhibitors (PAI‐1, PAI‐2) and by inhibitors of plasmin itself, maintaining a fine balance between activation and inhibition of ...
Bernard Perbal
wiley   +1 more source

Renal Heparan Sulfate Proteoglycans Modulate Fibroblast Growth Factor 2 Signaling in Experimental Chronic Transplant Dysfunction

, 2013
Depending on the glycan structure, proteoglycans can act as coreceptors for growth factors. We hypothesized that proteoglycans and their growth factor ligands orchestrate tissue remodeling in chronic transplant dysfunction.
van den Born, Jacob, Hillebrands, Jan-Luuk; id_orcid, Molema, G., Navis, G., Berden, Jo H. M., Celie, J.W., Mencke, R., Mencke, Rik, Hillebrands, Jan-Luuk, Celie, Johanna W. A. M., van Goor, Harry; id_orcid, Berden, J.H.M., Boersema, Miriam, Boersema, M., Molema, Grietje; id_orcid, Rienstra, H., Rienstra, Heleen, Katta, K., Born, J. van den, Navis, Gerjan, Katta, Kirankumar, Adepu, Saritha, van Goor, Harry, Hillebrands, J.L., Molema, Grietje, Goor, H. van, Adepu, S.   +26 more
core   +1 more source

Hydrogen Sulfide Rescues Microglia From HIV Tat‐Driven Ferroptosis: Implications for HIV‐Associated Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
HIV Tat induces ferroptosis and proinflammatory activation in microglia through iron accumulation and oxidative stress. Hydrogen sulfide donor NaHS suppresses HIV Tat‐induced ferroptosis by restoring redox balance, reinforcing the SLC7A11‐GPX4 axis, and attenuating microglial inflammation, highlighting hydrogen sulfide as a potential therapeutic ...
Aitizaz Ul Ahsan, Frida L. Martínez‐Cuevas, Elias Horanieh, Seema Singh, Uma Maheswari Deshetty, Palsamy Periyasamy, Shilpa Buch   +6 more
wiley   +1 more source

Molecular Modelling of the Complex Polysaccharide Heparan Sulphate

Heparan Sulphate plays an important role in many life processes and so an understanding of its role as a universal co-receptor is of great importance. Traditionally oligosaccharides derived from the related molecule heparin have been at the forefront of
Swift, Simone
core  

Sensing and Communicating β‐Cell Stress in the Context of T1D Etiology: New Opportunities for Therapeutic Impact

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Type 1 diabetes (T1D) results from the immune‐mediated destruction of insulin‐producing pancreatic β‐cells. Recent human studies show that early β‐cell stress maladaptations precede overt immune cell infiltration. DOC2B, a vesicle secretion regulatory protein that supports β‐cell functionality and resilience against stress, declines early in T1D ...
Diana Esparza, Chathurani S. Jayasena, Tijana Jovanovic‐Talisman, Debbie C. Thurmond   +3 more
wiley   +1 more source

Heparan sulfate proteoglycans in cancer: Pathogenesis and therapeutic potential. [PDF]

Adv Cancer Res, 2023
Yang H, Wang L.
europepmc   +1 more source

Regulation of autophagy, lipid metabolism, and neurodegenerative pathology by heparan sulfate proteoglycans. [PDF]

Front Genet, 2022
Schultheis N, Becker R, Berhanu G, Kapral A, Roseman M, Shah S, Connell A, Selleck S.   +7 more
europepmc   +1 more source