Results 121 to 130 of about 239,929 (209)
EXT proteins: Role in heparan sulfate Assembly and in Tumor biology [PDF]
, 2018 The exostosin family of proteins is necessary for heparan sulfate biosynthesis. Heparan sulfate polysaccharide biosynthesis is one of several different forms of proteinglycosylation processes that take place in the Golgi apparatus.
Sembajwe, Lawrence Fred
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Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells
Haematologica, 2012 Background Although mobilization of hematopoietic stem cells and hematopoietic progenitor cells can be achieved with a combination of granulocyte colony-stimulating factor and plerixafor (AMD3100), improving approaches for hematopoietic progenitor cell ...
Fabio Di Giacomo +6 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Integrative single‐cell multi‐omics analysis reveals molecular heterogeneity among piriform cortex principal neurons and identifies Reln+ superficial‐layer neurons as a selectively vulnerable population in Alzheimer's disease. Cross‐region comparison with entorhinal cortex layer II neurons reveals a shared Gpc5‐high/Sort1‐low vulnerability‐associated ...
Jiayue Meng +9 more
wiley +1 more source
Chemistry and biology of heparin and heparan sulfate /
, 2005 The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan
Garg, Hari G. +2 more
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My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award
JOR SPINE, Volume 9, Issue 3, September 2026.ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley +1 more source
Advances in FGF/FGFR Signaling: Implications for Disease and Therapy
MedComm, Volume 7, Issue 9, September 2026.The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song +4 more
wiley +1 more source
MedComm – Oncology, Volume 5, Issue 3, September 2026.This review provides a comprehensive overview of carbon dot–based technologies for breast cancer diagnosis and therapy, including their toxicity profiles. It outlines how C‐dots function as a versatile platform—serving simultaneously as therapeutic agents, drug‐delivery vehicles, and bioimaging tools. The article also highlights cutting‐edge approaches
Srija Sur, Pegah Varamini
wiley +1 more source
Neuroprotection, Volume 4, Issue 3, Page 213-228, September 2026.ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan +3 more
wiley +1 more source
Cathepsin X binds to cell surface heparan sulfate proteoglycans
, 2005 Glycosaminoglycans have been shown to be important regulators of activity of several papain-like cathepsins. Binding of glycosaminoglycans to cathepsins thus directly affects catalytic activity, stability or the rate of autocatalytic activation of ...
Nader, H. B. +8 more
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Human Cytomegalovirus Genetic Diversity, Clinical Relevance, and Emerging Insights
Reviews in Medical Virology, Volume 36, Issue 5, September 2026.ABSTRACT Human cytomegalovirus (HCMV) is a globally prevalent virus that poses a significant public health concern, especially for newborns and immunocompromised patients, causing a wide range of infections. Clinical outcomes associated with HCMV infection include congenital disease, graft rejection in transplant recipients, and life‐threatening ...
Hajar Y. AlQahtani +2 more
wiley +1 more source