Lipid-Linked Heparan Sulfate Proteoglycan.
Trends in Glycoscience and Glycotechnology, 1991 ヘパラン硫酸のコアタンパク質に脂質が共有結合すると、これらの遺伝子産物と細胞膜間に新しい分子結合が出来ることになる。プロテオグリカンは糖脂質化することで細胞頂上部へのふるい分けと標的となる膜への移動を行ない、細胞表面のプロテオグリカンが酵素反応により敏速に遊離される機構が出来上がる。プロテオグリカンが脂肪酸でアシル化されることは、疎水的な相互作用と、恐らく受容体を介した結合を仲介し、細胞内のプロテオグリカン/プロテオグリカン同士の相互作用の新しい機構を提供し、代謝回転に直接的な役割を果たすかも知れない。脂質を介した繋留に必要となる微細構造上の要求性や複合的なな酵素反応装置が同定出来ると、プロテオグリカンのこの新しい翻訳後の修飾が機能的に重要であることが明らかとなるであろう。
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Neurology InternationalGlucocorticoids are used during glioblastoma treatment to prevent the cerebral edema effect surrounding normal brain tissue. The aim of our study was to investigate the long-term effects of multiple administrations of glucocorticoids onto the ...
Stanislav D. Aladev +6 more
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Heparan sulfate proteoglycan is an important attachment factor for cell entry of Akabane and Schmallenberg viruses [PDF]
, 2017 Akabane (AKAV) and Schmallenberg (SBV) viruses are Orthobunyavirus transmitted by arthropod vectors with a broad cellular tropism in vitro as well as in vivo Both AKAV and SBV cause arthrogryposis-hydranencephaly syndrome in ruminants.
Horimoto, Taisuke +6 more
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Opticin Binds to Heparan and Chondroitin Sulfate Proteoglycans
Investigative Opthalmology & Visual Science, 2005 The extracellular matrix glycoprotein opticin is a small leucine-rich repeat proteoglycan/protein family member that was discovered associated with vitreous humor collagen fibrils. Opticin is present throughout the vitreous, but is particularly concentrated at the internal limiting lamina, where it colocalizes with type XVIII collagen.
Hindson, V. John +3 more
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Nature Communications, 2019 Proteoglycans are glycosylated proteins that play a number of structural and signalling functions. Here, Corti, Wang et al. show that the N-terminal sequence of proteoglycan Syndecan-2 selectively increases 6-O sulfation of its heparan sulfate chains ...
Federico Corti +11 more
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Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature. [PDF]
, 2018 Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and ...
Andreuzzi, Eva +5 more
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Bench-to-bedside review: The role of glycosaminoglycans in respiratory disease. [PDF]
, 2006 The extracellular matrix (ECM) plays a significant role in the mechanical behaviour of the lung parenchyma. The ECM is composed of a three-dimensional fibre mesh that is filled with various macromolecules, among which are the glycosaminoglycans (GAGs ...
PELOSI P.P. +2 more
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P1‐445: Glycosaminoglycan sulfate moieties and chain length important for heparan sulfate proteoglycan interactions with amyloid‐beta [PDF]
, 2008 Nienke Timmer +2 more
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Flow cytometry analysis of mouse islet cell expressionof heparan sulfate (HS), heparan sulfate proteoglycans (HSPGs) and heparanase (HPSE) v1 [PDF]
, 2020 Sarah Popp +2 more
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Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells
Haematologica, 2012 Background Although mobilization of hematopoietic stem cells and hematopoietic progenitor cells can be achieved with a combination of granulocyte colony-stimulating factor and plerixafor (AMD3100), improving approaches for hematopoietic progenitor cell ...
Fabio Di Giacomo +6 more
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