Results 101 to 110 of about 23,189 (236)

Cathepsin X binds to cell surface heparan sulfate proteoglycans

, 2005
Glycosaminoglycans have been shown to be important regulators of activity of several papain-like cathepsins. Binding of glycosaminoglycans to cathepsins thus directly affects catalytic activity, stability or the rate of autocatalytic activation of ...
Nader, H. B., Nantes, I. L., Stefe, L., Turk, B., Juliano, L., Tersariol, ILS, Nascimento, F. D., Rizzi, CCA, Carmona, A. K.   +8 more
core   +1 more source

APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans.

, 2021
Atherosclerotic cardiovascular disease causes heart attacks and strokes, which are the leading causes of mortality worldwide1. The formation of atherosclerotic plaques is initiated when low-density lipoproteins bind to heparan-sulfate proteoglycans ...
Simon, Tabassome, Kubicek, Stefan, Scharnagl, Hubert, Jørgensen, Helle F, Smeets, D., Afonyushkin, T., Fogelstrand, Per,, Jorgensen, H. F., Porsch, Florentina, Ozsvar-Kozma, Maria, Frommlet, Florian, Weißer, Juliane, Mayer, F. J., März, Winfried, Fogelstrand, Per, Hess, Henry, Tsiantoulas, D., Borén, Jan, Binder, Christoph J, Danchin, N., Smeets, Diede, Enders, Lennart, Danchin, Nicolas, Schneider, P., Pasterkamp, Gerard, Porsch, F., Kiss, M. G., Hendrikx, T., Lambert, J., Borén, Jan,, Eslami, M., Murphy, J. E., Simon, T., Lambert, Jordi, Göderle, Laura, Murphy, Jane E, Frommlet, F., Donzé, Olivier, Hess, H., Hoke, Matthias, Binder, C. J., Eslami, Mahya, Mallat, Z., Enders, L., Donze, O., Willen, L., Hoke, M., Mallat, Ziad, Goderle, L., Mayer, Florian J, Hendrikx, Tim, Willen, Laure, Afonyushkin, Taras, Mueller, A., Obermayer, Georg, Weisser, J., Ozsvar-Kozma, M., Marz, W., Kiss, Máté G, Mueller, André, Scharnagl, H., Tsiantoulas, Dimitrios, Obermayer, G., Clement, M., Schneider, Pascal, Pasterkamp, G., Kubicek, S., Clement, Marc   +67 more
core   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity

Frontiers in Molecular Neuroscience, 2018
Neural circuits consist of distinct neuronal cell types connected in specific patterns. The specificity of these connections is achieved in a series of sequential developmental steps that involve the targeting of neurites, the identification of synaptic ...
Giuseppe Condomitti, Giuseppe Condomitti, Joris de Wit, Joris de Wit   +3 more
doaj   +1 more source

Control of cell division in the adult brain by heparan sulfates in fractones and vascular basement membranes

, 2010
Regulation of cell division in adult tissues and organs requires the coordination of growth factors at the surface of potentially-dividing cells in specific anatomic loci named germinal niches.
Frederic Mercier, Vanessa Douet
core  

Angiopoietin‐like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride‐rich lipoproteins in humans

Journal of Internal Medicine, EarlyView.
Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Marcello Arca, Elias Björnson, Laura D'Erasmo, Alessia Di Costanzo, Simone Bini, Ilenia Minicocci, Daniele Tramontano, Stella Covino, Giuseppe Ciarlo, Manuela Lombardi, Sanni Söderlund, Niina Matikainen, Linda Andersson, Martin Adiels, Marja‐Riitta Taskinen, Chris J. Packard, Jan Borén   +16 more
wiley   +1 more source

Heparan sulfate in human cutaneous Meissner's and Pacinian corpuscles

, 2020
Heparan sulfate proteoglycans are pericellular/cell surface molecules involved in somatosensory axon guidance in the peripheral nervous system. However, the distribution of heparan sulfate proteoglycans in the extracellular matrix of human cutaneous ...
Cobo R., García-Mesa Y., García-Fernandez B., Quirós L.M., Feito J., García-Suárez O., Vega J.A., Martín-Biedma B., García-Piqueras J.   +8 more
core   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Multiple Administration of Dexamethasone Possesses a Deferred Long-Term Effect to Glycosylated Components of Mouse Brain

Neurology International
Glucocorticoids are used during glioblastoma treatment to prevent the cerebral edema effect surrounding normal brain tissue. The aim of our study was to investigate the long-term effects of multiple administrations of glucocorticoids onto the ...
Stanislav D. Aladev, Dmitry K. Sokolov, Anastasia V. Strokotova, Galina M. Kazanskaya, Alexander M. Volkov, Svetlana V. Aidagulova, Elvira V. Grigorieva   +6 more
doaj   +1 more source

Demystifying heparan sulfate-protein interactions. [PDF]

, 2014
Numerous proteins, including cytokines and chemokines, enzymes and enzyme inhibitors, extracellular matrix proteins, and membrane receptors, bind heparin.
Esko, Jeffrey D, Xu, Ding
core   +1 more source