Results 101 to 110 of about 39,579 (251)

Glycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for β3GalT6‐deficient spondylodysplastic Ehlers–Danlos syndrome

JIMD Reports, 2022
The spondylodysplastic type of Ehlers–Danlos syndrome (spEDS) is caused by genetic defects in the B4GALT7 or B3GALT6 genes both deranging the biosynthesis of the glycosaminoglycan linkage region of chondroitin/dermatan sulfate and heparan sulfate ...
Mahnaz Nikpour, Fredrik Noborn, Jonas Nilsson, Tim Van Damme, Olivier Kaye, Delfien Syx, Fransiska Malfait, Göran Larson   +7 more
doaj   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

RNA-Seq identifies SPGs as a ventral skeletal patterning cue in sea urchins [PDF]

, 2016
The sea urchin larval skeleton offers a simple model for formation of developmental patterns. The calcium carbonate skeleton is secreted by primary mesenchyme cells (PMCs) in response to largely unknown patterning cues expressed by the ectoderm.
Bardot, Evan, Blute, Todd A., Bradham, Cynthia A., Chaves, James, Chung, Oliver, Core, Amanda B., Coulombe-Huntington, Jasmin, Ferrell, Patrick, Fishman, Julie, Hameeduddin, Hajerah, Hewitt, Finnegan B., Hogan, John D., Ibn-Salem, Jonas, Keenan, Jessica L, Lee, David, Li, Christy, Luo, Lingqi, Oleinik, Ekaterina, Patel, Vijeta, Piacentino, Michael L., Poustka, Albert J., Ramachandran, Janani, Reyna, Arlene, Rose, Sviatlana, Speranza, Emily E., Yu, Jia, Zuch, Daniel T.   +26 more
core   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Role of Heparan Sulfate 2-O-Sulfotransferase in Prostate Cancer Cell Proliferation, Invasion, and Growth Factor Signaling

Prostate Cancer, 2011
Heparan-sulfate proteoglycans (HSPGs) are required for maximal growth factor signaling in prostate cancer progression. The degree of sulfate modification on the covalently attached heparan sulfate (HS) chains is one of the determining factors of growth ...
Brent W. Ferguson, Sumana Datta
doaj   +1 more source

Is Endothelial Nitric Oxide Synthase a Moonlighting Protein Whose Day Job is Cholesterol Sulfate Synthesis? Implications for Cholesterol Transport, Diabetes and Cardiovascular Disease [PDF]

, 2012
Theoretical inferences, based on biophysical, biochemical, and biosemiotic considerations, are related here to the pathogenesis of cardiovascular disease, diabetes, and other degenerative conditions.
Ali, Ann Lauritzen, Billecke, Brune, Cignarelli, Cordelier, Deniziak, Dimmeler, Drayer, Gajkowska, Girard, Gross, Hao, Hart, Ho, Hopwood, Hopwood, Ignarro, Jagger, Jakubowski, Joensuu, Laurie Lentz-Marino, McCully, Nakae, Pfennig, Pollack, Randriamboavonjy, Rearick, Robert Davidson, Seidel, Stephanie Seneff, Suzuki, Tedder, Teske, Tsai, Voeikov   +35 more
core   +4 more sources

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Heparan Sulfate Proteoglycans in Infection

, 2011
To cause infections, microbial pathogens elaborate a multitude of factors that interact with host components. Using these host–pathogen interactions to their advantage, pathogens attach, invade, disseminate, and evade host defense mechanisms to promote their survival in the hostile host environment.
Bartlett, Allison H., Park, Pyong Woo
openaire   +1 more source

Collagens and proteoglycans of the corneal extracellular matrix

Brazilian Journal of Medical and Biological Research, 2003
The cornea is a curved and transparent structure that provides the initial focusing of a light image into the eye. It consists of a central stroma that constitutes 90% of the corneal depth, covered anteriorly with epithelium and posteriorly with ...
Y.M. Michelacci
doaj   +1 more source

Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer [PDF]

, 2013
This work was supported in part by the Instituto de Salud Carlos III-Fondo de Investigación Sanitaria (grant PI051564).
Astudillo González, María Aurora, Castañón, S., Crespo, A., Fernández Vega, Iván, García Suárez, Olivia, Menéndez Rodríguez, María Primitiva, Quirós Fernández, Luis Manuel   +6 more
core   +1 more source