Results 71 to 80 of about 255,399 (229)
Proteoglycans and neuronal migration in the cerebral cortex during development and disease
Frontiers in Neuroscience, 2015 Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many proteins including growth factors, chemokines, axon guidance molecules,
Nobuaki eMaeda
doaj +1 more source
Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells [PDF]
Circulation Research, 2003 The objective of this study was to test whether a glycosaminoglycan component of the surface glycocalyx layer is a fluid shear stress sensor on endothelial cells (ECs). Because enhanced nitric oxide (NO) production in response to fluid shear stress is a characteristic and physiologically important response of ECs, we evaluated NO
Jeffry A, Florian +5 more
openaire +2 more sources
Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction
Medical Sciences, 2019 Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease.
Giulia Furini, Elisabetta A.M. Verderio
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BMEMat, EarlyView.The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu +8 more
wiley +1 more source
Heparanase: A Novel Therapeutic Target for the Treatment of Atherosclerosis
Cells, 2022 Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and its management places a huge burden on healthcare systems through hospitalisation and treatment.
Tien K. Nguyen +6 more
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Head &Neck, EarlyView.ABSTRACT Background To characterize the clinicoepidemiologic profile of HIV‐associated oral Kaposi sarcoma (OKS) and quantitatively synthesize its frequency, anatomical distribution, and temporal patterns across antiretroviral therapy (ART) eras. Methods Six databases and gray literature were searched.
Ericles Otávio +10 more
wiley +1 more source
Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids.
PLoS ONE, 2012 BackgroundStromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. Heparan sulfate proteoglycans, present both
Cecilia Österholm +6 more
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The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis [PDF]
Matrix Biology, 2018 Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in lipid homeostasis and inflammation. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions in the context of cardiovascular disease ...
Philip L.S.M. Gordts, Jeffrey D. Esko
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Demystifying heparan sulfate-protein interactions. [PDF]
, 2014 Numerous proteins, including cytokines and chemokines, enzymes and enzyme inhibitors, extracellular matrix proteins, and membrane receptors, bind heparin.
Esko, Jeffrey D, Xu, Ding
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Altered synthesis of heparan sulfate proteoglycans at low sulfate concentration
, 1986 The structural alterations in heparan sulfate produced by sulfate deprivation were studied in cell cultures of the Engelbreth-Holm-Swarm tumor. Tumor cells were labeled in vitro with [3H]glucosamine and/or [35S]sulfate in media containing either 300 μm ...
Hassell, John R. +2 more
core +1 more source