Results 51 to 60 of about 190,120 (268)

IS THE INCIDENCE TREND OF HEPARIN-INDUCED THROMBOCYTOPENIA DECREASED BY THE INCREASED USE OF LOW-MOLECULAR-WEIGHT-HEPARIN?

Mediterranean Journal of Hematology and Infectious Diseases, 2015
Background: The increasing trend of using low-molecular-weight-heparin (LMWH) versus unfractionated heparin (UFH) in hospitalized adult patients is raising concerns about the incidence of heparin-induced thrombocytopenia (HIT).
Fahad Al-Eidan
doaj   +1 more source

Blood loss in primary total knee arthroplasty-body temperature is not a significant risk factor-a prospective, consecutive, observational cohort study [PDF]

, 2015
BACKGROUND: Hypothermia related to anaesthesia and operating theatre environment is associated with increased blood loss in a number of surgical disciplines, including total hip arthroplasty.
Beller, Elaine, Dan, Michael, Jones, Peter, Liu, David, Martos, Sara Martinez, Randle, Ray   +5 more
core   +2 more sources

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Bioequivalence of a biosimilar enoxaparin (Cloti‐Xa™) and its innovator (Clexane®): A single‐dose, randomized, double‐blind, two‐period, two‐treatment, two‐sequence, crossover, balanced study in healthy human subjects

Pharmacology Research & Perspectives, 2022
Currently, several biosimilars of low‐molecular‐weight heparins (LMWHs) with differing potencies are being developed and marketed globally. Thus, it is important that the potency of each biosimilar LMWH be compared with its innovator's molecule.
Sumit Saxena, Manu Chaudhary, Saransh Chaudhary, Anmol Aggarwal   +3 more
doaj   +1 more source

pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells [PDF]

, 2019
Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding.
Korzhikov-Vlakh, Viktor, Pilipenko, Iuliia, Rühl, Eckart, Schäfer-Korting, Monika, Sharoyko, Vladimir, Tennikova, Tatiana, Zhang, Nan, Zoschke, Christian   +7 more
core   +1 more source

Safety of Needle Electromyography in Critically Ill Patients [PDF]

, 2020
Introduction: To evaluate the safety of needle electromyography (EMG) in critically ill intensive care unit (ICU) patients who are on anticoagulants and have comorbidities that increase the risk of bleeding and infections.
Bollu, Pradeep, Brannagan, Thomas, Digala, Lakshmi, Govindarajan, Raghav, Nagarajan, Elanagan, Yelam, Anudeep   +5 more
core   +2 more sources

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

The anti-factor Xa range for low molecular weight heparin thromboprophylaxis

Hematology Reports, 2015
Low molecular weight heparins (LMWHs) are now the mainstay option in the prevention and treatment of venous thromboembolism. In some patients receiving therapeutic doses of LMWH, activity can be measured by quantifying the presence of Anti-factor Xa ...
Matthew Y. Wei, Salena M. Ward
doaj   +1 more source

Prophylaxis for venous thromboembolic disease in pregnancy and the early postnatal period [PDF]

, 2010
Some women are at risk of forming blood clots in a deep vein during pregnancy, after a caesarean birth, or during the first few weeks after childbirth. If part of the clot breaks off and lodges in a blood vessel in the lungs, it can be life-threatening ...
Abou-Nassar, Abou-Nassar, Alfirevic, Alikhan, Andersen, Atrash, Badawy, Barbour, Bates, Blomback, Brenner, Brenner, Brenner, Brenner, Brenner, Brenner, Brill-Edwards, Brocklehurst, Brocklehurst, Brocklehurst, Burrows, Casele, Casele, Chistolini, Cohen, Conard, Connolly, Cornette, Dargaud, Dendrinos, Dittmer, Ellison, Ellison, Ellison, Empson, Farquharson, Friederich, Gates, Gates, Gates, Gherman, Gibson, Hall, Hamersley, Harenberg, Heilman, Heilmann, Heit, Hill, Hill, Howell, Högberg, Kaandorp, Kakkos, Kamin, Knight, Krauss, Kutteh, Kutteh, Larciprete, Letsky, Lewis, Lindhagen, Lindqvist, Macklon, Middeldorp, Nelson-Piercy, Noble, Orme, Paull, Pettila, Pettila, Pomp, Rai, Ramos, Rey, Rey, Rodger, Rodger, Rodger, Rutherford, Segal, Simpson, Stefano, Stephenson, Taylor, Testroote, Thaler, Tulppala, Veciana, Walker, Welti, Wu   +92 more
core   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source