Results 61 to 70 of about 190,120 (268)

Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients

EBioMedicine, 2020
Coronavirus disease-2019 (COVID-19) is associated with severe inflammation in mainly the lung, and kidney. Reports suggest a beneficial effect of the use of heparin/low molecular weight heparin (LMWH) on mortality in COVID-19.
Baranca Buijsers, Cansu Yanginlar, Marissa L. Maciej-Hulme, Quirijn de Mast, Johan van der Vlag   +4 more
doaj   +1 more source

Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain [PDF]

, 2008
Phosphatidylserine (PS)-dependent erythrocyte adhesion to endothelium and sub-endothelial matrix components is mediated in part via thrombospondin (TSP). While TSP exhibits multiple cell-binding domains, the PS-binding site on TSP is unknown.
Betal, Suhita G., Setty, Yamaja
core   +2 more sources

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

Advanced Healthcare Materials, EarlyView.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold, Stefanie Heltmann‐Meyer, Xuen J. Ng, Thomas Scheibel, Tobias Fey, Harald Wajant, Carol Geppert, Andreas Arkudas, Dominik Steiner, Raymund E. Horch   +9 more
wiley   +1 more source

Comparisons of anticoagulatory and therapeutic effects of low-molecular-weight heparin sodium versus sodium citrate in patients with severe acute kidney injury on continuous renal replacement therapy

Linchuang shenzangbing zazhi, 2021
Objective To explore the effects of sodium citrate anticoagulation on inflammatory state in patients with severe acute renal injury（AKI）on continuous renal replacement therapy（CRRT）.Methods From January 2018 to December 2019,50 AKI patients on CRRT in ...
Munire Abuliz, Zhang Jing-jing, Munire Erken, Li Su-hua, Wang Shun   +4 more
doaj  

Multifunctional and biologically active matrices from multicomponent polymeric solutions [PDF]

, 2012
A functionalized electrospun matrix for the controlled-release of biologically active agents, such as growth factors, is presented. The functionalized matrix comprises a matrix polymer, a compatibilizing polymer and a biomolecule or other small ...
Casper, Cheryl, Kiick, Kristi L., Rabolt, John, Yamaguchi, Nori   +3 more
core   +1 more source

Microenvironment Modulation‐Based Nanomaterial‐Loaded Hydrogel Dressings for Diabetic Foot Ulcers: Research Progress and Future Perspectives

Advanced Materials Interfaces, EarlyView.
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing, Chen Hong, Fan Weijing, Huang Renyan, You Yang, Liu Guobin   +5 more
wiley   +1 more source

Multi-component hybrid hydrogels – understanding the extent of orthogonal assembly and its impact on controlled release [PDF]

, 2017
This paper reports self-assembled multi-component hybrid hydrogels including a range of nanoscale systems and characterizes the extent to which each component maintains its own unique functionality, demonstrating that multi-functionality can be achieved ...
Abidine, Abul-Haija, Adams, Ahola, Albanyan, Amabilino, Babu, Banerjee, Beamish, Bimalendu, Boekhoven, Boekhoven, Bonina, Brizard, Bromfield, Bromfield, Bromfield, Bromfield, Bromfield, Buerkle, Calamai, Chakraborty, Chakraborty, Chau, Chen, Colquhoun, Cornwell, Cornwell, Cornwell, Corwnell, Das, Das, Draper, Draper, Du, Edelman, Escuder, Fan, Fechner, Fernández-Muiños, Fleming, Gutowska, Gutowska, Hanabusa, Heeres, Himmelein, Hirst, Hirst, Hirst, Hoare, Hou, Hussein, Iannuzzi, Kim, Laupheimer, Lee, Li, Liechty, Liu, Liu, Loira-Pastoriza, McLennan, Metanovic, Middeldorp, Moffat, Moffat, Morris, Nebot, Okesola, Onogi, Onogi, Pont, Rabenstein, Radivojsa, Raeburn, Raeburn, Rahfoth, Rajangam, Recha-Sancho, Rodrigo, Roveri, Sakiyama-Elbert, Sakiyama-Elbert, Sakiyama-Elbert, Sangeetha, Serwer, Singh, Skilling, Stubenrauch, Vieira, Wang, Webber, Wlodarczyk-Biegun, Yu   +93 more
core   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Thromboprophylaxis during pregnancy for prevention of adverse complications in patients with inherited thrombophilia: a literature review [PDF]

Journal of Biomedical & Clinical Research
Compared with non-pregnant women, pregnancy alone carries a three- to fivefold higher risk of venous thromboembolism (VTE). Despite the increasing use of low-molecular-weight heparin in identified high-risk patients, pulmonary embolism is still the ...
Zlatko Kirovakov, Elitsa Gyokova, Nadezdha Hinkova, Emiliana Konova   +3 more
doaj   +3 more sources

Low-molecular-weight heparin and unfractionated heparin decrease Th-1, 2, and 17 expressions. [PDF]

PLoS ONE, 2014
BACKGROUND: We evaluated the effects of T helper cell differentiation in a mite-allergic animal model treated with inhaled heparins of different molecular weight. METHOD: BALB/c mice were divided into four groups: 1. Control, 2. Mite intratracheal (mIT),
Jing-Ning Huang, Ming-Chin Tsai, Shun-Lung Fang, Margaret Dah-Tsyr Chang, Yu-Rou Wu, Jaw-Ji Tsai, Lin-Shien Fu, Heng-Kuei Lin, Yi-Jun Chen, Tsai-Wei Li   +9 more
doaj   +1 more source