Results 51 to 60 of about 522,479 (352)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Heparin bonded lines offer a solution that is difficult to implement Rapid Response to Dobson,R "Half the cases of bacteraemia in hospitals in England are linked to devices) [PDF]

, 2003
[Full text] The BMJ news report[1] that devices, particularly central venous lines, are linked to over half the cases of hospital acquired bacteraemia has long been a source of concern to clinicians in intensive care. Unfortunately, one simple, effective
Gilbert, R, Howard, R, Mok, Q
core  

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Perioperative optimization of Crohn's disease

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 10-26, January 2023., 2023
Most Crohn's disease patients require surgery during the course of their illness, especially those who experience complications. The management of perioperative medications and surgery‐related decision‐making should be individualized and patient‐centered based on a multidisciplinary approach.
Chun‐Chi Lin, Hung‐Hsin Lin, Hui‐Chuen Chen, Nai‐Chia Chen, I‐Lun Shih, Ji‐Shiang Hung, Te‐Cheng Yueh, Feng‐Fan Chiang, Ping‐Wei Lin, Yuan‐Yao Tsai, Shu‐Chen Wei   +10 more
wiley   +1 more source

The potential impact of Covid-19 on the capacity of routine laboratory tests to detect heparin-induced thrombocytopenia

Thrombosis Journal, 2022
In Covid-19, anticoagulation with heparin is often administered to prevent or treat thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a severe complication of heparin treatment, caused by heparin-dependent, platelet activating anti ...
Dominik F. Draxler, Justine Brodard, Björn Zante, Stephan M. Jakob, Jan Wiegand, Johanna A. Kremer Hovinga, Anne Angelillo-Scherrer, Alicia Rovo   +7 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies

Blood Advances, 2017
: Anti-protamine (PRT)/heparin antibodies are a newly described class of heparin-dependent antibodies occurring in patients exposed to PRT and heparin during cardiac surgery.
Grace M. Lee, Manali Joglekar, Maragatha Kuchibhatla, Sanjay Khandelwal, Rui Qi, Lubica Rauova, Gowthami M. Arepally   +6 more
doaj  

Effect of Non-Anticoagulant N-Desulfated Heparin on Basic Fibroblast Growth Factor Expression, Angiogenesis, and Metastasis of Gastric Carcinoma In Vitro and In Vivo

Gastroenterology Research and Practice, 2012
Objective. The present study was performed to investigate the effect of N-desulfated heparin on basic fibroblast growth factor (bFGF) expression, tumor angiogenesis and metastasis of gastric carcinoma. Methods.
Jin-Lian Chen, Jing Fan, Ming-Xiang Chen, Ying Dong, Jian-Zhong Gu   +4 more
doaj   +1 more source

Hydrolytic and lysozymic degradability of chitosan systems with heparin-mimicking pendant groups [PDF]

, 2016
Chitosan (CT) is an antibacterial polysaccharide that has been investigated for drug carriers, haemostats and wound dressings. For these applications, customised CT devices can often be obtained with specific experimental conditions, which can irreversibly alter native biopolymer properties and functions and lead to unreliable material behaviour.
arxiv   +1 more source

Universal Proteomic Signature After Exercise‐Induced Muscle Injury in Muscular Dystrophies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Several neuromuscular disorders (NMDs) are characterized by progressive muscle damage and are marked by the elevation of circulating muscle proteins from activity‐related injury. Despite a diverse array of genetic drivers, many NMDs share similar patterns of exercise intolerance and higher concentrations of muscle injury proteins ...
Mads G. Stemmerik, Benjamin Barthel, Nanna R. Andersen, Sofie V. Skriver, Alan J. Russell, John Vissing   +5 more
wiley   +1 more source