Results 1 to 10 of about 857 (131)

Real‐World Experience with a Human Fibrinogen Concentrate: Clinical Data from Adult and Pediatric Patients Requiring Fibrinogen for Bleeding Control and Prevention

open access: yesThe Journal of Clinical Pharmacology, Volume 63, Issue 11, Page 1186-1196, November 2023., 2023
Abstract Human fibrinogen concentrate (Fibryga) received temporary approval for fibrinogen replacement therapy in France (2017), with subsequent full approval for congenital and acquired hypofibrinogenemia. We evaluated real‐world use for on‐demand treatment of bleeding and prophylaxis to enhance our knowledge on fibrinogen concentrate as an option for
Francois Stéphan   +8 more
wiley   +1 more source

Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia

open access: yesEuropean Journal of Neurology, Volume 30, Issue 5, Page 1335-1345, May 2023., 2023
Abstract Background and purpose Cerebral venous sinus thrombosis due to vaccine‐induced immune thrombotic thrombocytopenia (CVST‐VITT) is an adverse drug reaction occurring after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination.
Katarzyna Krzywicka   +52 more
wiley   +1 more source

Neurological symptoms and complications in predominantly hospitalized COVID‐19 patients: Results of the European multinational Lean European Open Survey on SARS‐Infected Patients (LEOSS)

open access: yesEuropean Journal of Neurology, Volume 28, Issue 12, Page 3925-3937, December 2021., 2021
We retrospectively analyzed data from 6537 predominantly hospitalized COVID‐19 patients registered in the European multinational Lean European Open Survey on SARS‐Infected Patients (LEOSS) registry between January 2020 and February 2021. Common neurological symptoms were excessive tiredness (28.0%), headache (18.5%), nausea/emesis (16.6%), muscular ...
Nina N. Kleineberg   +31 more
wiley   +1 more source

Umbilical cord mesenchymal stem cells for COVID‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial

open access: yesSTEM CELLS Translational Medicine, Volume 10, Issue 5, Page 660-673, May 2021., 2021
Abstract Acute respiratory distress syndrome (ARDS) in COVID‐19 is associated with high mortality. Mesenchymal stem cells are known to exert immunomodulatory and anti‐inflammatory effects and could yield beneficial effects in COVID‐19 ARDS. The objective of this study was to determine safety and explore efficacy of umbilical cord mesenchymal stem cell (
Giacomo Lanzoni   +30 more
wiley   +1 more source

Recovery from Liver Failure and Fibrosis in a Rat Portacaval Anastomosis Model after Neurointermediate Pituitary Lobectomy

open access: yesJournal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
Liver diseases, including cirrhosis, viral hepatitis, and hepatocellular carcinoma, account for approximately two million annual deaths worldwide. They place a huge burden on the global healthcare systems, compelling researchers to find effective treatment for liver fibrosis‐cirrhosis.
Martín Muñoz-Ortega   +8 more
wiley   +1 more source

Single‐molecule mechanochemical characterization of E. coli pol III core catalytic activity

open access: yesProtein Science, Volume 26, Issue 7, Page 1413-1426, July 2017., 2017
Abstract Pol III core is the three‐subunit subassembly of the E. coli replicative DNA polymerase III holoenzyme. It contains the catalytic polymerase subunit α, the 3′ → 5′ proofreading exonuclease ε, and a subunit of unknown function, θ. We employ optical tweezers to characterize pol III core activity on a single DNA substrate.
M. Nabuan Naufer   +4 more
wiley   +1 more source

Investigation of Luminescence Characteristics of Osmium(II) Complexes in the Presence of Heparin Polyanions

open access: yesInternational Journal of Analytical Chemistry, Volume 2013, Issue 1, 2013., 2013
The luminescence characteristics of six osmium carbonyl complexes with phenanthroline (phen) or bipyridine (bpy) and pyridine (py), 4‐phenylpyridine (4‐phpy), or triphenylphosphine (PPh3) complexes in the presence of polyanion heparin were studied in both ethanol and aqueous solutions.
Yixi Xie   +7 more
wiley   +1 more source

Evaluation of Wedged Arterial Injection as a New Technique for Delivery of Experimental Therapeutic Sustances into the Porcine Pancreas

open access: yesJournal of Diabetes Research, Volume 2011, Issue 1, 2011., 2011
Objectives. To prospectively evaluate the technical feasibility and efficacy of wedged arterial injection (WAI) as a potential route for experimental selective therapy to the pancreas of healthy pigs. Materials and Methods. Selective angiographies were completed in ten pigs under general anaesthesia.
Rafael Latorre   +8 more
wiley   +1 more source

Physiologic Responses to Infrarenal Aortic Cross‐Clamping during Laparoscopic or Conventional Vascular Surgery in Experimental Animal Model: Comparative Study

open access: yesAnesthesiology Research and Practice, Volume 2008, Issue 1, 2008., 2008
The aim of this study was to compare the hemodynamic and ventilatory effects of prolonged infrarenal aortic cross‐clamping in pigs undergoing either laparotomy or laparoscopy. 18 pigs were used for this study. Infrarenal aortic crossclamping was performed for 60 minutes in groups I (laparotomy, n = 6) and II (laparoscopy, n = 6). Group III (laparoscopy,
María F. Martín-Cancho   +7 more
wiley   +1 more source

Comparative Evaluation of Follicular Flushing Frequency and Scraping Time During Ovum Pick‐Up in Mares: Effects on Oocyte Recovery Rate and Technical Considerations

open access: yesReproduction in Domestic Animals, Volume 61, Issue 2, February 2026.
ABSTRACT Transvaginal ultrasound‐guided follicular aspiration or ovum pick‐up (OPU) has become the standard technique for oocyte collection in mares for intracytoplasmic sperm injection (ICSI). Although repeated follicular flushes and wall scraping are commonly used to improve oocyte recovery rate (ORR), the relative contribution of each remains ...
Adrián Márquez‐Moya   +4 more
wiley   +1 more source

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