Repurposing Heparin as Antimalarial: Evaluation of Multiple Modifications Toward In Vivo Application [PDF]
, 2022 Heparin is a promising antimalarial drug due to its activity in inhibiting Plasmodium invasion of red blood cells and to the lack of resistance evolution by the parasite against it, but its potent anticoagulant activity is preventing the advance of ...
Aláez Versón, Carlos Raúl +4 more
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Einstein (São Paulo)Objective To determine the presence of glycosaminoglycans in the extracellular matrix of connective tissue from neoplastic and non-neoplastic colorectal tissues, since it has a central role in tumor development and progression.
Ana Paula Cleto Marolla +5 more
doaj +1 more source
Proteolysis, NaOH and ultrasound-enhanced extraction of anticoagulant and antioxidant sulfated polysaccharides from the edible seaweed, Gracilaria birdiae [PDF]
, 2014 The sulfated polysaccharides (SP) from the edible red seaweed, Gracilaria birdiae, were obtained using five different extraction conditions: Gracilaria birdiae 1 (GB1)-water; GB1s-water/sonication; GB1sp-water/sonication/proteolysis; GB2s-NaOH/sonication;
Costa, Leandro Silva +6 more
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Corneal Opacification in Infancy [PDF]
, 1972 The purpose of this paper is to present a systematic classification of the more important conditions that can manifest as corneal opacification in early infancy and to state its differential diagnostic ...
Ching, Florencio C.
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Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin [PDF]
, 2006 Cell surface heparan sulfate (HS) proteoglycans are carbohydrate-rich regulators of cell migratory, mitogenic, secretory, and inflammatory activity that bind and present soluble heparin-binding growth factors (e.g., fibroblast growth factor, Wnt, Hh ...
Beck, Shannon L. +8 more
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Chondroitin Sulfate Proteoglycans Are Associated with the Lesions of Alzheimer\u27s Disease [PDF]
, 1993 Chondroitin sulfate proteoglycans (CSPG) are extracellular matrix proteins inhibitory to neurite outgrowth in vitro and correlated with decreased neurite outgrowth after CNS injury.
Canning, David R. +3 more
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Recommendations on clinical trial design for treatment of Mucopolysaccharidosis Type III [PDF]
, 2017 Background Mucopolysaccharidosis type III is a progressive, neurodegenerative lysosomal storage disorder for which there is currently no effective therapy. Though numerous potential therapies are in development, there are several challenges to conducting
Bigger, Brian +12 more
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Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition [PDF]
, 2001 FGF signaling uses receptor tyrosine kinases that form high-affinity complexes with FGFs and heparan sulfate (HS) proteoglycans at the cell surface.
Allen, Benjamin L. +2 more
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European Journal of Biochemistry, 1989 The hydrophobic cell-surface proteoglycans of mouse mammary epithelial cells were purified by gel filtration, ion-exchange chromatography, and liposome incorporation. The size of the proteoglycans appeared to be directly proportional to the size of their
G. David, H. van den Berghe
semanticscholar +1 more source
小児における尿中酸性ムコ多糖類の排泄パターンに関する研究 第1編 正常小児の尿中酸性ムコ多糖類の排泄パターン [PDF]
, 1972 Qualitative and quantitative determination of urinary acid mucopolysaccharide (AMPS) have been studied by several methods including ECTEOLA cellulose column chromatography, Dowex I-X 2 column chromatography, electrophoresis, and enzymatic digestion with
南 良二
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