Results 121 to 130 of about 41,263 (236)

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Strangulated necrotic gastric fundus due to diaphragmatic hernia presenting with hydropneumothorax 5 years after left hepatic lobectomy: a case report and literature review. [PDF]

Front Surg
Zhu Y, Wang Q, Lai J, Qin Y, Sun L, Ye M, Li J.   +6 more
europepmc   +1 more source

Glutathione peroxidase 3 preserves hepatocyte mitochondrial quality control to enhance macrophage pro‐regenerative phenotype during liver regeneration

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
(1) GPX3 inhibits VDAC1 oligomerisation by directly binding to it. (2) The loss of GPX3 leads to VDAC1 oligomerisation, resulting in dysregulation of mitochondrial quality control, characterised by enhanced fission, weakened fusion and impaired autophagy.
Yuechen Wang, Jian Xu, Zeyu Zhu, Ye Zhang, Haoran Hu, Yiyun Gao, Yuting Tao, Feifan Yao, Suiqing Zhou, Weizhe Zhong, Zhuqing Rao, Haoming Zhou, Xuehao Wang   +12 more
wiley   +1 more source

Prognostic Role of CA19-9 in Patients Undergoing Hepatectomy for Colorectal Liver Metastases. [PDF]

Cancers (Basel)
Masuda T, Beppu T, Miyata T, Okabe H, Imai K, Sakamoto K, Miyamoto Y, Hayashi H.   +7 more
europepmc   +1 more source

Pathophysiologic Study of the Changes of Blood Flow in Portal Vein and Hepatic Artery and the Role of Administration of Regadenoson in Post-hepatectomy Liver Failure. [PDF]

Cureus
Massaras D, Masourou Z, Psarras G, Pantiora E, Kordeni KC, Massara M, Kontis EA, Vezakis A, Theodoraki K, Fragulidis GP.   +9 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Analysis of Determinants and Development of a Predictive Model for Postoperative Cognitive Dysfunction in Patients Undergoing Hepatectomy. [PDF]

J Clin Med
Li Y, Xu J, Xue B, Cao J, Yang H, Li X.
europepmc   +1 more source

Temporal Biomolecular Processes Underlying Recovery Following 90% Partial Hepatectomy: A Proteomics Study in Rats

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Background Post‐hepatectomy liver failure (PHLF) remains a limitation in the surgical treatment of liver cancer. The 90% partial hepatectomy (PH) rat model reliably induces biochemical PHLF and high mortality, providing a unique platform for identifying molecular pathways necessary for successful liver regeneration.
Andrea Lund, Jakob Kirkegård, Jens Randel Nyengaard, Frank Viborg Mortensen, Mikkel Thy Thomsen   +4 more
wiley   +1 more source

Treatment of hepatic hemangiomas in the era of laparoscopic surgery: Enucleation versus hepatectomy. [PDF]

J Int Med Res
Jiang B, Liu J, Yan XF, Xi SH, Fang XS, Wang XM.   +5 more
europepmc   +1 more source

Bioartificial Livers Developed From Gene‐Edited Pig Hepatocyte Organoids Improve Amino Acid and Lipid Profiles in the Plasma of Patients With Liver Failure

MedComm, Volume 7, Issue 6, June 2026.
A bioartificial liver (BAL) integrating GGTA1‐knockout porcine hepatocytes and R‐spondin1‐overexpressing endothelial organoids was tested using plasma from patients with acute‐on‐chronic liver failure (ACLF). The BAL system actively modulates amino acid and lipid metabolism, enhances detoxification, partially restores overall metabolic balance, and ...
Yuting He, Yang Deng, Xinglong Zhu, Mengyu Gao, Qin Liu, Wanliu Peng, Yanyan Zhou, Lang Bai, Ji Bao   +8 more
wiley   +1 more source