Results 131 to 140 of about 59,051 (216)

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Hepatitis B in Organ Transplantation—Current Evidence and Clinical Gaps

Transplant Infectious Disease, EarlyView.
ABSTRACT Over the past several decades there have been significant advances in nucleos(t)ide analogue (NA) antiviral therapy for hepatitis B virus (HBV) and global expansion of primary prevention through immunization. Despite this, HBV remains a leading cause of chronic liver disease globally, affecting over 250 million people.
Oscar A. Fernandez‐Garcia, Britta L. Hirsch, Irene A. Abela, Karen E. Doucette   +3 more
wiley   +1 more source

How to Do a Laparoscopic Left Hepatectomy for Cystic Lesions Compressing the Middle Hepatic Vein: The Hemodynamic Advantage of Pneumoperitoneum

ANZ Journal of Surgery, EarlyView.
Jonathan Ben Daniel, Krishna Kotecha, Kai Brown, Anubhav Mittal, Jaswinder Samra   +4 more
wiley   +1 more source

Temporary caval occlusion technique during right divisional hepatectomy for massive hepatocellular carcinoma with caudal vena cava compression/involvement in dogs

Veterinary Surgery, EarlyView.
Abstract Objective To describe the perioperative and long‐term outcomes of dogs with massive hepatocellular carcinoma (HCC) in the right hepatic division causing compression or involvement of the caudal vena cava (CVC) treated with right divisional hepatectomy using temporary caval occlusion (TCO). Study design Retrospective case series.
Kumiko Ishigaki, Kazushi Asano, Kei Tamura, Tatsuya Heishima, Takeshi Hayakawa, Teppei Fujimoto, Kenji Teshima   +6 more
wiley   +1 more source

Hypoxia and post-hepatectomy liver failure : a double-edged sword post-extended hepatectomy

Liver resection is the only curative treatment for liver tumors but is associated with a significant risk of post-hepatectomy liver failure (PHLF), marked by high mortality. The lack of mechanistic understanding limits treatment options.
De Rudder, Maxime
core  

Indocyanine Green Fluorescence Cholangiography With Selective Intraoperative Cholangiography: A Proposed Standard for Laparoscopic Cholecystectomy

ANZ Journal of Surgery, EarlyView.
Jaswinder S. Samra, Krishna Kotecha, Anubhav Mittal   +2 more
wiley   +1 more source

Staged caval occlusion enabling en bloc right divisional hepatectomy in two dogs with hepatocellular carcinoma

Veterinary Surgery, EarlyView.
Abstract Objective To describe staged pre‐renal caudal vena cava (CVC) occlusion before en bloc right divisional hepatectomy with segmental caval resection in two dogs with right divisional hepatocellular carcinoma (HCC) involving the CVC. Animals Two client‐owned, 11‐year‐old neutered male dogs (Siberian Husky and Shih Tzu).
Kumiko Ishigaki, Kazushi Asano
wiley   +1 more source

Clinical Utility and Safety of a Novel Ultraslim Catheter‐Type Peroral Cholangioscope/Pancreatoscope: A Single‐Center Case Series

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Peroral cholangioscopy (POCS) and peroral pancreatoscopy (POPS) enable direct intraductal visualization for pancreatobiliary disease diagnosis and management. Nonetheless, conventional devices have relatively large diameters, limiting their use in narrow ducts.
Hiroyuki Kojima, Shuntaro Mukai, Atsushi Sofuni, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Kazumasa Nagai, Yukitoshi Matsunami, Hirohito Minami, Noriyuki Hirakawa, Kyoko Asano, Kento Shionoya, Kazuki Hama, Takao Itoi   +13 more
wiley   +1 more source