Results 161 to 170 of about 694,423 (327)

Branched‐chain amino acids and all‐cause mortality in patients with liver cirrhosis, and the onset of diabetes in liver transplant recipients

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Our study demonstrates that total BCAA levels increase following liver transplantation. In patients with cirrhosis, higher total BCAA levels are associated with a reduced risk of all‐cause mortality. However, while this association is not observed in liver transplant recipients, elevated total BCAA levels are strongly linked to an increased risk of new‐
Yakun Li   +9 more
wiley   +1 more source

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial

open access: yesHepatology, 2017
J. Bajaj   +19 more
semanticscholar   +1 more source

Cortical hemodynamics of electrographic status epilepticus in the critically ill

open access: yesEpilepsia, Volume 66, Issue 3, Page 802-816, March 2025.
Abstract Objectives The pathophysiological mechanisms of status epilepticus (SE) underlying potential brain injury remain largely unclear. This study aims to employ functional near‐infrared spectroscopy (fNIRS) combined with video‐electroencephalography (vEEG) to monitor brain hemodynamics continuously and non‐invasively in critically ill adult ...
Ali Kassab   +6 more
wiley   +1 more source

Optimizing phenobarbital dosing in critically ill patients with refractory and superrefractory status epilepticus using a population pharmacokinetic model

open access: yesEpilepsia, EarlyView.
Abstract Objective Current weight‐based dosing fails to account for pharmacokinetic variability in refractory and superrefractory status epilepticus (RSE, SRSE). However, understanding pharmacokinetics in critically ill patients with varying degrees of organ dysfunction can improve both safety and efficacy.
Maximilian Stoschus   +9 more
wiley   +1 more source

Topiramate for the treatment of neonatal seizures and beyond

open access: yesEpilepsia, EarlyView.
Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley   +1 more source

Novel neuropathological observations in an adult with Dravet syndrome

open access: yesEpilepsia, EarlyView.
Abstract Dravet syndrome (DS) is a developmental and epileptic encephalopathy associated with pathogenic variants in the SCN1A gene. The neuropathological features of adult DS remain poorly understood. We report the postmortem findings of a 55‐year‐old woman with DS due to a confirmed SCN1A pathogenic variant leading to Nav1.1 loss of function ...
Danielle M. Andrade   +7 more
wiley   +1 more source

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