Results 171 to 180 of about 92,598 (348)

Non‐Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
In a multi‐centre study of obeticholic acid in primary biliary cholangitis, 45% discontinued the drug over 4 years, with 11% moving to combination therapy (fibrates). Of those continuing, response rates increased from 37% (1 year) to 55% (4 years). Non‐response at 12 months and cirrhosis were independent predictors of liver‐related events.
Nadir Abbas   +18 more
wiley   +1 more source

The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients with Cirrhosis

open access: yesمجله دانشکده پزشکی اصفهان, 2014
Background: Zinc deficiency is prevalent in Iran. Regarding the effect of zinc element on pathogenesis of cirrhosis and hepatic encephalopathy, the present study has been designed to assess the zinc deficiency in patients with cirrhosis, with and without
Rahmatollah Rafiei   +4 more
doaj  

Research Communication: The Cumulated Spontaneous Portosystemic Shunts (SPSS) Area Decreases After TIPS and Impacts on Prognosis

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
This study shows that both the total SPSS area and the cumulative SPSS diameter decrease significantly and persistently after TIPS placement, whereas the total shunt diameter increases slightly and the total shunt area remains stable. The relative change in SPSS area serves as an independent predictor of mortality. ABSTRACT We evaluated the dynamics of
Marlene Hintersteininger   +14 more
wiley   +1 more source

Alterations in Gut Microbiota and Metabolism in Cirrhotic Portal Hypertension: Implications for Disease Progression

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
In‐depth multiomics analyses revealed that the gut microbiota in patients with CPH is dysbiotic. Altered gut microbiota plays an important role in the progression of CPH and affects the host's arginine metabolism to promote arginine biosynthesis. The pro‐inflammatory effects of certain gut bacteria induce iNOS expression, which together act on the ...
Qun Zhang   +15 more
wiley   +1 more source

Biomarkers of Extracellular Matrix Remodelling Are Linked to Severity and Outcome of Advanced Chronic Liver Disease

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
Extracellular matrix (ECM) remodelling biomarkers reflect portal hypertension and disease severity in advanced chronic liver disease (ACLD). However, their predictive value for disease progression is largely restricted to compensated ACLD (cACLD). ABSTRACT Background Extracellular matrix (ECM) remodelling in advanced chronic liver disease (ACLD) is ...
Benedikt Simbrunner   +17 more
wiley   +1 more source

Portosystemic shunts and refractory hepatic encephalopathy: patient selection and current options

open access: yesHepatic Medicine: Evidence and Research, 2019
Cyriac Abby Philips, Sasidharan Rajesh, Philip Augustine, Guruprasad Padsalgi, Rizwan Ahamed The Liver Unit, Cochin Gastroenterology Group, Ernakulam Medical Centre, Cochin, Kerala, India Abstract: Portosystemic shunt (PS) syndrome encompasses a spectrum
Philips CA   +4 more
doaj  

914 PLASMA AROMATIC AMINO ACID LEVELS AS BETTER MARKERS FOR HEPATIC ENCEPHALOPATHY IN A PIG LIVER ISCHEMIC INJURY MODEL

open access: bronze, 2011
Joshua A. Bundy   +10 more
openalex   +1 more source

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