Results 1 to 10 of about 1,196,134 (401)

Programmed cell death in hepatic fibrosis: current and perspectives

Cell Death Discovery, 2023
The initiation, development and resolution of hepatic fibrosis are influenced by various cytokines, chemokines, damage-associated molecular patterns (DAMPs) and signaling pathways.
Ju-Lu Lu, Chuan-Xin Yu, Li-Jun Song
doaj   +2 more sources

New Drugs for Hepatic Fibrosis

Frontiers in Pharmacology, 2022
The morbidity and mortality of hepatic fibrosis caused by various etiologies are high worldwide, and the trend is increasing annually. At present, there is no effective method to cure hepatic fibrosis except liver transplantation, and its serious ...
Liang Shan, Liang Shan, Liang Shan, Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv, Xiongwen Lv, Xiongwen Lv   +10 more
doaj   +2 more sources

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

JCI Insight, 2021
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion ...
Noelia Arroyo, Laura Villamayor, Irene Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martín, David A. Cano, Anabel Rojas   +10 more
doaj   +2 more sources

Hepatic fibrosis [PDF]

Current Opinion in Gastroenterology, 2009
This review will summarize the most significant work that contributed to the understanding of liver fibrosis progression and resolution, which in turn has yielded new areas of therapeutic targeting.Liver fibrosis is the result of an imbalance between production and dissolution of extracellular matrix.
Jingjing, Jiao, Scott L, Friedman, Costica, Aloman   +2 more
openaire   +3 more sources

Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice

Nature Communications, 2023
Parabacteroides distasonis ( P. distasonis ) plays an important role in human health, including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that P.
Qi Zhao, Manyun Dai, Ruoyue Huang, Jingyi Duan, Ting Zhang, Weimin Bao, Jing-Yi Zhang, Shao-Qiang Gui, Shu-Min Xia, Cong-Ting Dai, Ying-mei Tang, F. Gonzalez, Fei Li   +12 more
semanticscholar   +1 more source

Research Progress of Structure, Function and Mechanism of Action of Mitofusin 2 in Liver Diseases [PDF]

Zhongguo quanke yixue, 2023
The liver is the largest metabolic organ in the human body, and impaired liver function can lead to a variety of acute and chronic liver diseases, which can affect the quality of life in mild cases or be life-threatening in severe cases. Therefore, it is
YUAN Xiwei, NAN Yuemin
doaj   +1 more source

Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism

Journal of Nanobiotechnology, 2023
Liver fibrosis is a chronic liver disease with the presence of progressive wound healing response caused by liver injury. Currently, there are no approved therapies for liver fibrosis.
Zilong Zhang, Jin Shang, Qinyan Yang, Zonglin Dai, Yuxin Liang, Chunyou Lai, Tianhang Feng, Deyuan Zhong, Haibo Zou, Lelin Sun, Y. Su, Su Yan, Jie Chen, Yutong Yao, Ying Shi, Xiaolun Huang   +15 more
semanticscholar   +1 more source

Hepatic fibrosis 2022: Unmet needs and a blueprint for the future

Hepatology, 2021
Steady progress over four decades toward understanding the pathogenesis and clinical consequences of hepatic fibrosis has led to the expectation of effective antifibrotic drugs, yet none has been approved.
S. Friedman, M. Pinzani
semanticscholar   +1 more source

Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis

Frontiers in Molecular Biosciences, 2023
Chronic liver disease or repeated damage to hepatocytes can give rise to hepatic fibrosis. Hepatic fibrosis (HF) is a pathological process of excessive sedimentation of extracellular matrix (ECM) proteins such as collagens, glycoproteins, and ...
Yuan Zhao, Xiaodan Deng, Guo-qi Xu, Jie Lin, Hua-Ze Lu, Jie Chen   +5 more
semanticscholar   +1 more source

ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis

Stem cell research & therapeutics, 2022
Background Hepatic fibrosis is a common pathologic stage in chronic liver disease development, which might ultimately lead to liver cirrhosis. Accumulating evidence suggests that adipose-derived stromal cells (ADSCs)-based therapies show excellent ...
Baitong Wu, Jiuxing Feng, Jingyi Guo, Jian Wang, Guanghui Xiu, Jiaqi Xu, Ke Ning, Bin Ling, Qing‐chun Fu, Junliang Xu   +9 more
semanticscholar   +1 more source