Results 11 to 20 of about 180,751 (262)
Current Opinion in Gastroenterology, 2009 This review will summarize the most significant work that contributed to the understanding of liver fibrosis progression and resolution, which in turn has yielded new areas of therapeutic targeting.Liver fibrosis is the result of an imbalance between production and dissolution of extracellular matrix.
Jingjing, Jiao +2 more
openaire +3 more sources
Research Progress of Structure, Function and Mechanism of Action of Mitofusin 2 in Liver Diseases [PDF]
Zhongguo quanke yixue, 2023 The liver is the largest metabolic organ in the human body, and impaired liver function can lead to a variety of acute and chronic liver diseases, which can affect the quality of life in mild cases or be life-threatening in severe cases. Therefore, it is
YUAN Xiwei, NAN Yuemin
doaj +1 more source
New Drugs for Hepatic Fibrosis
Frontiers in Pharmacology, 2022 The morbidity and mortality of hepatic fibrosis caused by various etiologies are high worldwide, and the trend is increasing annually. At present, there is no effective method to cure hepatic fibrosis except liver transplantation, and its serious ...
Liang Shan +10 more
doaj +1 more source
Pathogenesis of Viral Hepatitis-Induced Chronic Liver Disease: Role of Extracellular Vesicles
Frontiers in Cellular and Infection Microbiology, 2020 Extracellular vesicles are encapsulated lipid nanoparticles secreted by a variety of cell types in living organisms. They are known to carry proteins, metabolites, nucleic acids, and lipids as their cargoes and are important mediators of intercellular ...
Hong Kiat Lim +6 more
doaj +1 more source
Programmed cell death in hepatic fibrosis: current and perspectives
Cell Death Discovery, 2023 The initiation, development and resolution of hepatic fibrosis are influenced by various cytokines, chemokines, damage-associated molecular patterns (DAMPs) and signaling pathways.
Ju-Lu Lu, Chuan-Xin Yu, Li-Jun Song
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Hepatic fibrosis is the final pathway of several chronic liver diseases, which is characterized by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of hepatic stellate cells and oxidative stress (OS) play an important
Wenzhang Dai +17 more
doaj +1 more source
Scientific Reports, 2021 Aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 Index (Fib4) have been validated against liver biopsy for detecting advanced hepatic fibrosis in HFE hemochromatosis.
Sim Yee Ong +13 more
doaj +1 more source
Advances on Nanomedicines for Diagnosis and Theranostics of Hepatic Fibrosis
Advanced NanoBiomed Research, 2021 Hepatic fibrosis is induced by chronic hepatic injuries before it turns into hepatic cirrhosis/carcinoma. It is characterized by the formation of collagen and other extracellular matrices around damaged hepatic tissues; consequently, the normal ...
Xinghang Dai +5 more
doaj +1 more source
Pharmacological Research, 2023 Hepatic fibrosis is caused by liver damage as a consequence of wound healing response. Recent studies have shown that hepatic fibrosis could be effectively reversed, partly through regression of activated hepatic stellate cells (HSCs).
Liangyun Li +10 more
doaj +1 more source
Adipocytokines and hepatic fibrosis [PDF]
Trends in Endocrinology & Metabolism, 2015 Obesity and metabolic syndrome pose significant risk for the progression of many types of chronic illness, including liver disease. Hormones released from adipocytes, adipocytokines, associated with obesity and metabolic syndrome, have been shown to control hepatic inflammation and fibrosis.
Saxena, Neeraj K., Anania, Frank A.
openaire +2 more sources