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Hepatic triglyceride lipase

Hepatic triglyceride lipase
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Hepatic Lipase Deficiency

Critical Reviews in Clinical Laboratory Sciences, 1998
Hepatic lipase (HL) is an enzyme that is made primarily by hepatocytes (and also found in adrenal gland and ovary) and hydrolyzes phospholipids and triglycerides of plasma lipoproteins. It is secreted and bound to the hepatocyte surface and readily released by heparin. It is a member of the lipase superfamily and is homologous to lipoprotein lipase and
Philip W Connelly, Robert A. Hegele
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Lipoprotein lipase and hepatic lipase

Current Opinion in Lipidology, 1990
Lipoprotein metabolism involves two major steps (Eisenberg 1990). First, triglyceride (TG) rich lipoproteins bind transiently to lipoprotein lipase (LPL) at the vascular endothelium (Fig. 1). The enzyme rapidly hydrolyzes triglycerides, which accomplishes two things (Eckel 1989): it enables the tissues to utilize fatty acids from the lipoproteins, and ...
Thomas Olivecrona, Gunilla Bengtsson-Olivecrona   +1 more
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Mechanism of action of lipoprotein lipase and hepatic triglyceride lipase

American Heart Journal, 1987
Lipoprotein lipase (LPL) and hepatic triglyceride lipase (H-TGL) were isolated from human postheparin plasma, and their interfacial properties were examined with mixed monolayers of trioleoylglycerol and phosphatidylcholine. LPL showed a surface pressure optimum between 20 and 22 mN/m, whereas H-TGL activity decreased at lipid packing densities of ...
R L, Jackson, L R, McLean, R A, Demel
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Hepatic Lipase: A Member of a Family of Structurally Related Lipases

Lipids and Lipid Metabolism, 1987
Partial amino acid sequence of rat hepatic lipase was obtained by gas-phase microsequence analysis of proteolytic fragments. Sequence comparison to bovine lipoprotein lipase and porcine pancreatic lipase reveals a highly conserved region existing among these three physiologically distinct lipolytic enzymes.
John E Shively, M C Schotz, Howard Wong
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Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency

Biochemical and Biophysical Research Communications, 1991
In a kindred with three hyperlipidemic subjects who had premature atherosclerosis and complete deficiency of hepatic lipase activity, we had previously identified a novel structural hepatic lipase gene variant. We now report the identification of three more hepatic lipase gene mutations in this family and demonstrate that compound heterozygosity for ...
R A, Hegele, J A, Little, P W, Connelly
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Hepatic lipase purification and characterization

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1984
Hepatic lipase has been purified to homogeneity from rat liver homogenates. The purified enzyme exhibits a single band on SDS-polyacrylamide gel electrophoresis. The molecular size of the native hepatic lipase is 200 000, while on SDS-polyacrylamide gel electrophoresis the apparent minimum molecular weight of the enzyme is 53 000, suggesting that the ...
J S, Twu, A S, Garfinkel, M C, Schotz
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Triglyceride lipases in acute hepatitis

Clinica Chimica Acta, 1976
Two triglyceride lipases in postheparin plasma, the lipoprotein lipase (LPL) and the hepatic triglyceride lipase (H-TGL) were separated by heparin-sepharose affinity chromatography and studied in controls and patients during the course of acute hepatitis. All three patients had increased content of triglycerides in the low density lipoproteins, and two
J, Sauar, J P, Blomhoff, E, Gjone
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