Results 181 to 190 of about 43,155 (225)

Hepatic lipase in the rat

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1967
Abstract 1. 1. Whole homogenates of rat liver are capable of hydrolyzing artificial triglyceride emulsions in vitro at a pH of 7.4. The products of the reaction are primarily free fatty acids and glycerol. The lipolytic activity is progressively inactivated after 30 min at 37°. Hydrolysis is inhibited by divalent cations.
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Assay of lipoprotein lipase and hepatic lipase

1992
Abstract Lipoprotein lipase (LPL) and hepatic lipase (HL) are two key enzymes in the metabolism and interconversion of lipoproteins (1-3; Table 1). The reactions occur at endothelial surfaces of blood vessels, where the enzymes are attached by interaction with polyanions, probably heparan sulphate proteo glycans anchored in the ...
Gunilla Bengtsson-Olivecrona, Thomas Olivecrona   +1 more
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Familial Hepatic Lipase Deficiency

1986
We have described a kindred with familial hepatic lipase (HL) deficiency [1]. The proband presented with marked hyperlipoproteinemia and β-VLDL and was originally thought to have Type III hyperlipoproteinemia. However, he was investigated further because of an unusually high proportion of triglyceride in low density and high density lipoproteins and a ...
J A, Little, P W, Connelly
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Hepatic lipase and HDL metabolism

Current Opinion in Lipidology, 2000
Hepatic lipase is a lipolytic enzyme that has been suggested to have a role in HDL metabolism. Evidence suggests that HDL-cholesterol level is at least partly regulated by hepatic lipase level. Recent studies have shown that hepatic lipase not only hydrolyzes triglyceride and phospholipid in HDL, but also stimulates HDL cholesterol ester uptake by ...
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Human hepatic lipase mutations and polymorphisms

Human Mutation, 1992
Human hepatic lipase (HL) is a 477 residue glycoprotein that hydrolyzes triglycerides from plasma lipoproteins. Familial HL deficiency is a rare recessive disorder that is characterized by premature atherosclerosis and abnormal circulating lipoproteins.
R A, Hegele, L, Tu, P W, Connelly
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5 Lipoprotein Lipase and Hepatic Lipase

1983
Publisher Summary This chapter reviews information on the two major lipolytic enzymes in postheparin plasma, lipoprotein lipase (LpL), and hepatic triglyceride lipase (H-TGL), particularly focusing on their structure, mechanism of action, and role in lipoprotein metabolism.
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Enzymology and physiological role of hepatic lipase

Biochemical Society Transactions, 1985
Owen, J. S. & McIntyre, N. (1982) Trends Bioehem. Sci 7 , 95-98 Owen, J. S . , Hutton, R. A., Bruckdorfer, K. R., Day, R. C. & McIntyre, N. (1981) J. Lipid Res. 22, 423430 Owen, J. S., Bruckdorfer, K. R., Day, R. C. & McIntyre, N. (1982) J. Lipid Res. 23, 124-132 Owen, J. S., Brown, D. J. C., Harry, D. S . , McIntyre, N., Beaven, G.
H, Jansen, W C, Hülsmann
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Hepatic triglyceride lipase in diabetic dogs

Metabolism, 1985
Circulating triglyceride is cleared by a combination of hepatic triglyceride lipase (H-TGL) and lipoprotein lipase (LPL). Although LPL has been extensively studied in diabetes, the effect of insulinization on H-TGL activity has not been well characterized.
D L, Muller, C D, Saudek, D, Applebaum-Bowden   +2 more
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Hepatic lipase

Current Opinion in Lipidology, 1999
Hepatic lipase catalyses the hydrolysis of triglycerides and phospholipids in all major classes of lipoproteins. Genetic deficiency of this enzyme is associated with a unique plasma lipoprotein profile, characterized by hypertriglyceridemia and elevated concentrations of intermediate density lipoproteins and HDL.
J C, Cohen, G L, Vega, S M, Grundy
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Genetics and molecular biology of hepatic lipase

Current Opinion in Lipidology, 1996
Hepatic lipase is emerging as a major factor in the control of HDL metabolism. Hepatic lipase plays a central role in the hydrolysis of HDL2 triglycerides and phospholipids and in the concomitant apolipoprotein A-I efflux from this density class. New data suggest that allelic variation at the hepatic lipase gene locus accounts for 25% of the total ...
A, Bensadoun, D E, Berryman
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