Results 221 to 230 of about 157,614 (311)

Glucagon Receptor Deficiency Causes Early-Onset Hepatic Steatosis. [PDF]

Diabetes
Cacciottolo TM, Lawler K, Méndez-Acevedo KM, Mendes de Oliveira E, Syanda A, Henning E, Keogh JM, Bounds R, Smith M, Ashraf D, Harman D, Duckworth A, Godfrey EM, Watson L, Hoare M, Jones B, Baker A, Rashid T, Farooqi IS.   +18 more
europepmc   +1 more source

Elevated serum aminotransferases in an infant with failure to thrive: A clinicopathological case report

JPGN Reports, EarlyView.
Jamie M. Klapp, Lauren Nichols, Nicholas J. Gloude, Amber Hildreth, Kathleen B. Schwarz   +4 more
wiley   +1 more source

Retatrutide Shows Multiple Metabolic Benefits in Diet‐Induced Obese MASH Mouse and Hamster Models

Obesity, EarlyView.
ABSTRACT Objective/Methods Our aim was to evaluate the efficacy of the triple glucagon, GIP, and GLP‐1 receptor agonist retatrutide in diet‐induced obese MASH mouse and hamster models, two preclinical models that we routinely use for assessing new therapies targeting obesity.
François Briand, Camille Le Cudennec, Estelle Grasset, Natalia Breyner, Claire Bigot, Pierre Dillard, Thierry Sulpice   +6 more
wiley   +1 more source

Prevalence and Predictors of Hepatic Steatosis in Patients Undergoing Sleeve Gastrectomy: A Biopsy-proven Study. [PDF]

Obes Surg
Soliman R, Helmy A, Mikhail N, Ezzat H, Gad AM, Halim EA, Zalata K, Masoud R, Hassan A, Farahat A, Eisa MEEA, Elbasiony M, Shiha G.   +12 more
europepmc   +1 more source

Platelet‐Activating Factor Pathway in Women With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity

Obesity, EarlyView.
Increased hepatic PAFR expression in MASLD is associated with histological disease severity and may contribute to progression through platelet activation, whereas circulating Lp‐PLA2 levels lack discriminatory value as a noninvasive biomarker. ABSTRACT Objective This study aimed to investigate the platelet‐activating factor (PAF) pathway in obesity ...
Joan Duran‐Bertran, Helena Clavero‐Mestres, Razieh Mahmoudian, Sara Muñiz‐Piera, Carmen Aguilar, David Riesco, Javier Camaron, Salomé Martínez, Margarida Vives, Marta París, Fàtima Sabench, Teresa Auguet   +11 more
wiley   +1 more source

Sangyod rice extract attenuates oleic acid-induced hepatic steatosis by modulating apoptotic, inflammatory, and lipid metabolic pathways. [PDF]

Food Chem (Oxf)
Moolsup F, Suttithumsatid W, Woonnoi W, Saetan J, Noothong D, Tanasawet S, Sukketsiri W.   +6 more
europepmc   +1 more source

Prevalence of non‐alcoholic fatty liver disease and its association with different combinations of weight status and metabolic abnormalities in children aged 6–18 years

Pediatric Investigation, EarlyView.
Children with non‐overweight combined with metabolic risk factors might increase the risk of non‐alcoholic fatty liver disease (NAFLD). These findings suggest that overweight and obesity should not be the sole criterion for NAFLD screening in children. In particular, more attention should be given to non‐overweight combined with metabolic abnormalities
Peiyu Ye, Luting Peng, Liwang Gao, Xiaonan Li, Qin Liu, Pei Xiao, Liang Wang, Xiaoyan Shi, Jun Ma, Yanhui Dong, Dongling Dai, Qinghua Yang, Xinchun Chen, Xin Fan, Naijun Wan, Jin Zhang, Bin Li, Lin Zhou, Guangsheng Wu, Lin Yang, Yan He, Yinkun Yan, Jie Mi   +22 more
wiley   +1 more source

Chronic Stress Induces Hepatic Steatosis via Brain-Hepatic Sympathetic Axis Mediated Catecholamine Resistance. [PDF]

Int J Biol Sci
Wu S, Liu J, Huang S, Guo Y, Bi Y.
europepmc   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Choline attenuates NEFA-induced hepatic steatosis via GNMT regulation in hepatocytes. [PDF]

Stress Biol
Du X, Wang L, Dai Y, Lu J, Li H, Wang D, Zhang J, Cai C, Liu S, Yao J, Wang J, Cao Y.   +11 more
europepmc   +1 more source