Results 41 to 50 of about 367,035 (204)

Mechanisms of hepatocellular toxicity associated with dronedarone and other mitochondrial toxicants [PDF]

open access: yes, 2014
Idiosyncratic drug-induced liver injury is a rare toxic event that typically occurs at therapeutic doses, which are generally safe to the majority of patients.
Felser, Andrea Debora
core   +1 more source

Diffuse hepatic steatosis.

open access: yes, 2021
Diffuse hepatic steatosis seen on standard of care imaging (a) and VSI (b). In both images there is significant increase in hepatic echogenicity.
Deborah J. Rubens (11261691)   +13 more
core   +1 more source

Effect of Vildagliptin on Hepatic Steatosis [PDF]

open access: yesThe Journal of Clinical Endocrinology & Metabolism, 2015
Although dipeptidyl-peptidase-4 inhibitors exert their major action via an incretin mechanism, a favorable effect of vildagliptin on lipid metabolism remains unexplained.The objective was to examine hepatic triglyceride levels and insulin sensitivity on vildagliptin.This was a 6-month, randomized, double-blind, placebo-controlled trial.This was an ...
Macauley M   +7 more
openaire   +3 more sources

Comparative study of ultrasound attenuation analysis and controlled attenuation parameter in the diagnosis and grading of liver steatosis in non-alcoholic fatty liver disease patients

open access: yesBMC Gastroenterology
Purpose To assess the diagnostic performance of Ultrasound Attenuation Analysis (USAT) in the diagnosis and grading of hepatic steatosis in patients with non-alcoholic fatty liver disease (NAFLD) using Controlled Attenuation Parameters (CAP) as a ...
Mengyun Wang   +10 more
doaj   +1 more source

Hepatic steatosis with significant fibrosis is associated with an increased 10-year estimated risk of cardiovascular disease in adults with type 1 diabetes mellitus

open access: yesCardiovascular Diabetology, 2023
Background We assessed whether hepatic steatosis with or without significant fibrosis (determined by validated non-invasive biomarkers) is associated with an increased 10-year estimated risk for cardiovascular disease (CVD) in people with type 1 diabetes
Alessandro Mantovani   +18 more
doaj   +1 more source

Perturbations métaboliques hépatiques : implication des xénosenseurs CAR (Constitutive Androstane Receptor) et PXR (Pregnane X Receptor) et d'un perturbateur endocrinien, le Bisphénol A [PDF]

open access: yes, 2012
L'exposition à des contaminants environnementaux est suspectée de perturber les fonctions endocrino-métaboliques des organismes et contribuer au développement de pathologies métaboliques comme le diabète et la stéatose hépatique non alcoolique.
Marmugi, Alice
core  

The role of systemically perturbed PTEN and PKBß/AKT2 signaling in accumulation of hepatic lipids [PDF]

open access: yes, 2013
Non-alcoholic fatty liver disease (NAFLD) is a major health problem and occurs frequently in the context of obesity and type 2 diabetes mellitus (T2D).
Schultze, Simon Manuel
core   +1 more source

Increased Expression of Enzymes of Triglyceride Synthesis Is Essential for the Development of Hepatic Steatosis

open access: yesCell Reports, 2013
Molecular mechanisms underpinning nonalcoholic fatty liver disease (NAFLD) are not well understood. The earliest step of NAFLD is hepatic steatosis, which is one of the main characteristics of aging liver.
Jingling Jin   +8 more
doaj   +1 more source

Elevated systemic monocyte chemoattractrant protein-1 in hepatic steatosis without significant hepatic inflammation

open access: yes, 2011
Non-alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and the metabolic syndrome. It encompasses a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). The latter develops
Lukas Moleda   +19 more
core   +1 more source

Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits [PDF]

open access: yes, 2011
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis ...
Palmer Cameron D.   +803 more
core   +5 more sources

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