Results 111 to 120 of about 205,561 (359)

Decursin ameliorates carbon-tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells [PDF]

, 2022
Renye Que, Mengxing Cao, Yan-Cheng Dai, Yi Zhou, Yirong Chen, Liubing Lin   +5 more
openalex   +1 more source

Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ. [PDF]

, 2015
Background&aimsHepatic stellate cells (HSCs) play a key role in liver fibrosis in various chronic liver disorders including nonalcoholic fatty liver disease (NAFLD).
Alisi, Anna, de Araujo Horcel, Lucas, Eguchi, Akiko, Feldstein, Ariel E, Johnson, Casey D, Nobili, Valerio, Panera, Nadia, Papouchado, Bettina G, Pinatel, Eva M, Povero, Davide   +9 more
core  

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

miR-12135 ameliorates liver fibrosis accompanied with the downregulation of integrin subunit alpha 11

iScience
Summary: Cirrhosis is becoming one of the most common diseases worldwide. Abnormal upregulation of transforming growth factor β (TGF-β) signaling plays a pivotal role in the excess activation of hepatic stellate cells.
Motofumi Kumazoe, Emi Miyamoto, Chihiro Oka, Miyuki Kondo, Ren Yoshitomi, Hiroaki Onda, Yu Shimada, Yoshinori Fujimura, Hirofumi Tachibana   +8 more
doaj   +1 more source

TLR4-Dependent Secretion by Hepatic Stellate Cells of the Neutrophil-Chemoattractant CXCL1 Mediates Liver Response to Gut Microbiota.

PLoS ONE, 2016
Background & aimsThe gut microbiota significantly influences hepatic immunity. Little is known on the precise mechanism by which liver cells mediate recognition of gut microbes at steady state.
Amélie E Bigorgne, Beena John, Mohammad R Ebrahimkhani, Masami Shimizu-Albergine, Jean S Campbell, Ian N Crispe   +5 more
doaj   +1 more source

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Nature, 2022
A. Filliol, Yoshinobu Saito, A. Nair, D. Dapito, Le-xing Yu, Aashreya Ravichandra, S. Bhattacharjee, Silvia Affò, N. Fujiwara, H. Su, Qiuyan Sun, Thomas M. Savage, J. Wilson-Kanamori, J. Caviglia, Likang Chin, Dongning Chen, Xiaobo Wang, S. Caruso, Jin Ku Kang, A. D. Amin, Sebastian Wallace, R. Dobie, Deqi Yin, Oscar M Rodriguez-Fiallos, C. Yin, Adam Mehal, Benjamin Izar, R. Friedman, R. Wells, U. Pajvani, Y. Hoshida, H. Remotti, Nicholas Arpaia, J. Zucman‐Rossi, M. Karin, N. Henderson, I. Tabas, R. Schwabe   +37 more
semanticscholar   +1 more source

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis

Cells, 2019
Activation of hepatic stellate cells (HSCs) and their trans-differentiation towards collagen-secreting myofibroblasts (MFB) promote liver fibrosis progression. During chronic liver disease, resting HSCs become activated by inflammatory and injury signals.
O. Krenkel, J. Hundertmark, T. Ritz, R. Weiskirchen, F. Tacke   +4 more
semanticscholar   +1 more source

Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. [PDF]

, 2017
Human serum amyloid P (hSAP), a member of the pentraxin family, inhibits the activation of fibrocytes in culture and inhibits experimental renal, lung, skin and cardiac fibrosis.
Bao, Xiaoli, Brenner, David A, Cong, Min, Fan, Xu, Jia, Jidong, Kisseleva, Tatiana, Liu, Tianhui, Wang, Ping, You, Hong, Zhai, Qingling, Zhang, Dong, Zhao, Weihua, Zhuang, Hui   +12 more
core   +2 more sources

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Hepatic Stellate Cells in the Context of Liver Fibrosis

Khyber Medical University Journal, 2013
Liver fibrosis is a wound healing response caused by either acute or chronic cellular damage. If left untreated, can lead to cirrhosis that progress to liver failure and can causes death.
Muhammad Ashfaq khan, Roshan Ali
doaj