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Hepatic Stellate Cells and Liver Fibrosis
Comprehensive Physiology, 2013AbstractHepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a remarkable range of functions in normal and injured liver. Derived embryologically from septum transversum mesenchyme, their precursors include submesothelial cells that invade the liver parenchyma from the hepatic capsule.
Juan E, Puche +2 more
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Transcriptional regulation of hepatic stellate cells
Advanced Drug Delivery Reviews, 2009Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a wound-healing myofibroblast and acquires potent pro-inflammatory and pro-fibrogenic activities.
Mann J, Mann DA
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Signal transduction in hepatic stellate cells
Liver, 1998ABSTRACT— Hepatic stellate cells (HSC) are presently regarded as one of the key cell types involved in the progression of liver fibrosis and in the related pathophysiological and clinical complications. Following acute or chronic liver tissue damage, HSC undergo a process of activation towards a phenotype characterised by increased proliferation ...
PINZANI, MASSIMO +2 more
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Hepatic Stellate Cells in Liver Tumor
2020Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are the most common types of primary liver cancers. Moreover, the liver is the second most frequently involved organ in cancer metastasis after lymph nodes. The tumor microenvironment is crucial for the development of both primary and secondary liver cancers.
Hidenori, Shiraha +2 more
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1999
In 1876, von Kupffer discovered star-shaped cells in the hepatic lobules using the gold chloride method, and called them “Sternzellen” (stellate cells). In 1898, however, he misconstrued these cells as phagocytic cells. The original stellate cells were rediscovered in 1971.
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In 1876, von Kupffer discovered star-shaped cells in the hepatic lobules using the gold chloride method, and called them “Sternzellen” (stellate cells). In 1898, however, he misconstrued these cells as phagocytic cells. The original stellate cells were rediscovered in 1971.
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(+)‐Catechin attenuates activation of hepatic stellate cells
Cell Biology International, 2014Abstract(+)‐Catechin is a type of catechin present in large amounts in açaí fruits and cocoa seeds. Besides its antioxidant and anti‐inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)‐catechin on hepatic stellate cells.
Bragança de Moraes, Cristina Machado +11 more
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2001
Carl Kupffer, by the use of a gold chloride staining method, detected in mammalian livers a population of stellate-shaped cells that were located perisinusoidally, always attached to the sinusoidal capillaries and also to the parenchymal cells (Kupffer 1876, cited by Wake 1980).
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Carl Kupffer, by the use of a gold chloride staining method, detected in mammalian livers a population of stellate-shaped cells that were located perisinusoidally, always attached to the sinusoidal capillaries and also to the parenchymal cells (Kupffer 1876, cited by Wake 1980).
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Adipogenic Phenotype of Hepatic Stellate Cells
Alcoholism: Clinical and Experimental Research, 2005Abstract: Transdifferentiation of hepatic stellate cells (HSC) constitutes a major cellular event in the genesis of alcoholic liver fibrosis and cirrhosis and molecular mechanisms underlying this process is incompletely understood. Our laboratory proposed several years ago that HSC quiescence requires the transcriptional program known to be integral ...
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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