Results 311 to 320 of about 79,018 (355)
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P311 modulates hepatic stellate cells migration
Liver International, 2014AbstractBackground & AimsLiver fibrosis is induced by the accumulation of extracellular matrix, deposited mainly by activated hepatic stellate cells (HSCs). One key characteristic of stellate cell activation is the directional migration to the site of injury during the wound‐healing process.
Stradiot, Leslie +4 more
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1998
The hepatic stellate cell (HSC) has emerged as a major regulator of normal liver homeostasis and growth, as well as a key effector in the hepatic fibrogenic response. In this chapter, we review the biological characteristics of the hepatic stellate cell, addressing historical perspectives, morphologic characteristics, methods of isolation, and their ...
Victor Ankoma-Sey, Scott L. Friedman
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The hepatic stellate cell (HSC) has emerged as a major regulator of normal liver homeostasis and growth, as well as a key effector in the hepatic fibrogenic response. In this chapter, we review the biological characteristics of the hepatic stellate cell, addressing historical perspectives, morphologic characteristics, methods of isolation, and their ...
Victor Ankoma-Sey, Scott L. Friedman
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Transcriptional Regulation in Hepatic Stellate Cells
Seminars in Liver Disease, 2001Modulation of gene expression through altered transcription regulates stellate cell behavior in normal liver and following hepatic injury. Transcription factors are generally classified according to conserved motifs within either the activation- or DNA- binding domains of the molecules.
F J, Eng, S L, Friedman
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Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation
Journal of Laboratory and Clinical Medicine, 1999The prevention of cirrhosis in alcohol-fed baboons by the administration of a soybean extract-43% to 50% of which was dilinoleoyl-phosphatidylcholine (DLPC) and 24% of which was 1,palmitoyl 2,linoleoyl-phosphatidylcholine (PLPC)-was associated with a significant reduction in the number of stellate cells transformed to myofibroblast-like cells. To study
J, Poniachik +3 more
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Hepatic Stellate Cells and Liver Fibrosis
Comprehensive Physiology, 2013AbstractHepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a remarkable range of functions in normal and injured liver. Derived embryologically from septum transversum mesenchyme, their precursors include submesothelial cells that invade the liver parenchyma from the hepatic capsule.
Juan E, Puche +2 more
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Signal transduction in hepatic stellate cells
Liver, 1998ABSTRACT— Hepatic stellate cells (HSC) are presently regarded as one of the key cell types involved in the progression of liver fibrosis and in the related pathophysiological and clinical complications. Following acute or chronic liver tissue damage, HSC undergo a process of activation towards a phenotype characterised by increased proliferation ...
PINZANI, MASSIMO +2 more
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Hepatic Stellate Cells in Liver Tumor
2020Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are the most common types of primary liver cancers. Moreover, the liver is the second most frequently involved organ in cancer metastasis after lymph nodes. The tumor microenvironment is crucial for the development of both primary and secondary liver cancers.
Hidenori, Shiraha +2 more
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1999
In 1876, von Kupffer discovered star-shaped cells in the hepatic lobules using the gold chloride method, and called them “Sternzellen” (stellate cells). In 1898, however, he misconstrued these cells as phagocytic cells. The original stellate cells were rediscovered in 1971.
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In 1876, von Kupffer discovered star-shaped cells in the hepatic lobules using the gold chloride method, and called them “Sternzellen” (stellate cells). In 1898, however, he misconstrued these cells as phagocytic cells. The original stellate cells were rediscovered in 1971.
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(+)‐Catechin attenuates activation of hepatic stellate cells
Cell Biology International, 2014Abstract(+)‐Catechin is a type of catechin present in large amounts in açaí fruits and cocoa seeds. Besides its antioxidant and anti‐inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)‐catechin on hepatic stellate cells.
Bragança de Moraes, Cristina Machado +11 more
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2001
Carl Kupffer, by the use of a gold chloride staining method, detected in mammalian livers a population of stellate-shaped cells that were located perisinusoidally, always attached to the sinusoidal capillaries and also to the parenchymal cells (Kupffer 1876, cited by Wake 1980).
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Carl Kupffer, by the use of a gold chloride staining method, detected in mammalian livers a population of stellate-shaped cells that were located perisinusoidally, always attached to the sinusoidal capillaries and also to the parenchymal cells (Kupffer 1876, cited by Wake 1980).
openaire +1 more source