Results 31 to 40 of about 49,283 (257)

rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP-7/Smad1/5/8 pathway

Parasites & Vectors, 2019
Background Activation of hepatic stellate cells is the dominant pathogenic event during the process of liver fibrosis. Bone morphogenic protein (BMP)-7 has recently been identified as an anti-fibrotic factor and leads to phosphorylation of Smad1/5/8 in ...
Liuting Chen, Qi Zhou, Ertao Liu, Jiali Zhang, Lian Duan, Dandan Zhu, Jinling Chen, Yinong Duan   +7 more
doaj   +1 more source

Analysis of the effects of xanthohumol on hepatic homeostasis, inflammation, fibrosis and cancerogenesis

, 2009
Xanthohumol is the major prenylated chalcone found in hops, and it has been shown to exhibit various biological effects. However, xanthohumol effects on liver cells or in liver diseases, respectively, are widely unknown.
Dorn, Christoph Michael
core   +1 more source

Synergy of Phospholipid—Drug Formulations Significantly Deactivates Profibrogenic Human Hepatic Stellate Cells [PDF]

, 2019
The pivotal role of hepatic stellate cells (HSCs) in orchestrating the bidirectional process of progression and regression of liver fibrosis makes them an ideal target for exploring new antifibrotic therapies.
Valentino, Gina, Brülisauer, Lorine, Luciani, Paola, Zivko, Cristina, Weber, Florian, Florian Weber, Cristina Zivko, Gina Valentino, Lorine Brülisauer, Paola Luciani   +9 more
core   +1 more source

Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis

Frontiers in Endocrinology, 2022
Fatty liver disease is a spectrum of liver pathologies ranging from simple hepatic steatosis to non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and culminating with the development of cirrhosis or hepatocellular carcinoma
Bing Yang, Liqing Lu, Dongmei Zhou, Wei Fan, Lucía Barbier-Torres, Justin Steggerda, Heping Yang, Xi Yang   +7 more
doaj   +1 more source

Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression

, 2022
Hepatocyte senescence is associated with liver fibrosis. However, the possibility of a direct, causal relation between hepatocyte senescence and hepatic stellate cell (HSC) activation was the subject of this study. Liver biopsy specimens obtained from 50
Pramudi Wijayasiri, Timothy J. Kendall, Aloysious D. Aravinthan, Alexander, Graeme J., Kaye, Philip, Wijayasiri, Pramudi, Graeme J. Alexander, Philip Kaye, Stuart Astbury, Kendall, Timothy J., Fiona Oakley, Kendall, Timothy J.; id_orcid, Aravinthan, Aloysious D., Oakley, Fiona, Astbury, Stuart   +14 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy

Nature Communications, 2019
Activated hepatic stellate cells are associated with fibrosis and liver metastases. Here, the authors identify an endogenous role of relaxin in regulating the activation of hepatic stellate cells and report nanoparticle-mediated relaxin gene therapy to ...
Mengying Hu, Ying Wang, Ligeng Xu, Sai An, Yu Tang, Xuefei Zhou, Jingjing Li, Rihe Liu, Leaf Huang   +8 more
doaj   +1 more source

Hepatic Stellate Cell Senescence in Liver Fibrosis:Characteristics, Mechanisms and Perspectives [PDF]

, 2021
Myofibroblasts play an important role in fibrogenesis. Hepatic stellate cells are the main precursors of myofibroblasts. Cellular senescence is the terminal cell fate in which proliferating cells undergo irreversible cell cycle arrest.
Serna-Salas, Sandra, Damba, Turtushikh, Moshage, Han, Zhang, Mengfan, Moshage, Han; id_orcid, Demaria, Marco; id_orcid, Demaria, Marco, Serna-Salas, Sandra; id_orcid, Borghesan, Michaela   +8 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress

Frontiers in Cell and Developmental Biology, 2021
Hepatic fibrosis is the final pathway of several chronic liver diseases, which is characterized by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of hepatic stellate cells and oxidative stress (OS) play an important
Wenzhang Dai, Wenzhang Dai, Qin Qin, Zhiyong Li, Li Lin, Ruisheng Li, Zhie Fang, Yanzhong Han, Wenqing Mu, Lutong Ren, Tingting Liu, Xiaoyan Zhan, Xiaoyan Zhan, Xiaohe Xiao, Xiaohe Xiao, Xiaohe Xiao, Zhaofang Bai, Zhaofang Bai   +17 more
doaj   +1 more source