Results 21 to 30 of about 42,931 (262)

Playing Jekyll and Hyde—The Dual Role of Lipids in Fatty Liver Disease

Cells, 2020
Lipids play Jekyll and Hyde in the liver. On the one hand, the lipid-laden status of hepatic stellate cells is a hallmark of healthy liver. On the other hand, the opposite is true for lipid-laden hepatocytes—they obstruct liver function.
Martijn R. Molenaar, Louis C. Penning, J. Bernd Helms   +2 more
doaj   +1 more source

Storage of vitamin A in extrahepatic stellate cells in normal rats

Journal of Lipid Research, 1997
In mammals, vitamin A is primarily stored as retinyl esters in hepatic stellate cells under normal dietary intake of the vitamin. Previously, extrahepatic vitamin A-storing stellate cells have only been identified in animals maintained on a vitamin A ...
N E Nagy, K B Holven, N Roos, H Senoo, N Kojima, K R Norum, R Blomhoff   +6 more
doaj   +1 more source

Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish

Disease Models & Mechanisms, 2016
Alcoholic liver disease (ALD) results from alcohol overconsumption and is among the leading causes of liver-related morbidity and mortality worldwide. Elevated expression of vascular endothelial growth factor (VEGF) and its receptors has been observed in
Changwen Zhang, Jillian L. Ellis, Chunyue Yin   +2 more
doaj   +1 more source

NOX as a Therapeutic Target in Liver Disease

Antioxidants, 2022
The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or NOX) plays a critical role in the inflammatory response and fibrosis in several organs such as the lungs, pancreas, kidney, liver, and heart. In the liver, NOXs contribute,
Deyamira Matuz-Mares, Héctor Vázquez-Meza, María Magdalena Vilchis-Landeros   +2 more
doaj   +1 more source

PPAR Gamma and Hepatic Stellate Cells [PDF]

Comparative Hepatology, 2004
Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC.
Hazra, Saswati, Miyahara, Takeo, Rippe, Richard A, Tsukamoto, Hidekazu   +3 more
openaire   +2 more sources

Levels of hepatic Th17 cells and regulatory T cells upregulated by hepatic stellate cells in advanced HBV-related liver fibrosis

Journal of Translational Medicine, 2017
Background Liver fibrosis which mainly occurs upon chronic hepatitis virus infection potentially leads to portal hypertension, hepatic failure and hepatocellular carcinoma.
Xiaoyan Li, Yujie Su, Xuefeng Hua, Chan Xie, Jing Liu, Yuehua Huang, Liang Zhou, Min Zhang, Xu Li, Zhiliang Gao   +9 more
doaj   +1 more source

Liver cirrhosis and hepatic stellate cells [PDF]

Acta Cirurgica Brasileira, 2006
The cirrhosis represents the final stage of several chronic hepatic diseases and it is characterized by the presence of fibrosis and morphologic conversion from the normal hepatic architecture into structurally abnormal nodules. In the evolution of the disease there is loss of the normal vascular relationship and portal hypertension.
Brandão, Daniel Ferracioli, Ramalho, Leandra Naira Zambelli, Ramalho, Fernando Silva, Zucoloto, Sérgio, Martinelli, Ana de Lourdes Candolo, Castro e Silva, Orlando de   +5 more
openaire   +4 more sources

Human Liver Stem Cell-Derived Extracellular Vesicles Target Hepatic Stellate Cells and Attenuate Their Pro-fibrotic Phenotype

Frontiers in Cell and Developmental Biology, 2021
Liver fibrosis occurs in response to chronic liver injury and is characterized by an excessive deposition of extracellular matrix. Activated hepatic stellate cells are primarily responsible for this process.
Giulia Chiabotto, Giulia Chiabotto, Elena Ceccotti, Elena Ceccotti, Marta Tapparo, Marta Tapparo, Giovanni Camussi, Giovanni Camussi, Stefania Bruno, Stefania Bruno   +9 more
doaj   +1 more source

Metabolic reprogramming in hepatic stellate cells: unveiling a novel therapeutic target for liver fibrosis

Frontiers in Physiology
Liver fibrosis represents a pathological reparative process for the liver that occurs due to persistent harm, closely linked to sustained liver damage and inflammation.
Bingbing He, Ning Wang, Ruijuan Yan, Junzhe Jiao, Junzhe Jiao, Haibo Zhang, Haibo Zhang, Qian Huang, Qi Xi, Zhanjie Chang, Xi Guan, Xi Guan, Shuguang Yan, Shuguang Yan, Jingtao Li, Jingtao Li   +15 more
doaj   +1 more source

rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP-7/Smad1/5/8 pathway

Parasites & Vectors, 2019
Background Activation of hepatic stellate cells is the dominant pathogenic event during the process of liver fibrosis. Bone morphogenic protein (BMP)-7 has recently been identified as an anti-fibrotic factor and leads to phosphorylation of Smad1/5/8 in ...
Liuting Chen, Qi Zhou, Ertao Liu, Jiali Zhang, Lian Duan, Dandan Zhu, Jinling Chen, Yinong Duan   +7 more
doaj   +1 more source