Results 21 to 30 of about 49,283 (257)

Toll-Like Receptor Signaling and Liver Fibrosis

Gastroenterology Research and Practice, 2010
Liver fibrosis occurs as a wound-healing scar response following acute and chronic liver inflammation including alcoholic liver disease, non-alcoholic steatohepatitis, hepatitis B and C, and autoimmune hepatitis.
Tomonori Aoyama, Yong-Han Paik, Ekihiro Seki   +2 more
doaj   +1 more source

Reelin expression in human liver of patients with chronic hepatitis C infection

European Journal of Histochemistry, 2017
Reelin is a secreted extracellular glycoprotein that plays a critical role during brain development. Several studies have described Reelin expression in hepatic stellate cells of the human liver. In order to investigate the possible role of Reelin in the
Simone Carotti, Giuseppe Perrone, Michelina Amato, Umberto Vespasiani Gentilucci, Daniela Righi, Maria Francesconi, Claudio Pellegrini, Francesca Zalfa, Maria Zingariello, Antonio Picardi, Andrea Onetti Muda, Sergio Morini   +11 more
doaj   +1 more source

Storage of vitamin A in extrahepatic stellate cells in normal rats

Journal of Lipid Research, 1997
In mammals, vitamin A is primarily stored as retinyl esters in hepatic stellate cells under normal dietary intake of the vitamin. Previously, extrahepatic vitamin A-storing stellate cells have only been identified in animals maintained on a vitamin A ...
N E Nagy, K B Holven, N Roos, H Senoo, N Kojima, K R Norum, R Blomhoff   +6 more
doaj   +1 more source

Playing Jekyll and Hyde—The Dual Role of Lipids in Fatty Liver Disease

Cells, 2020
Lipids play Jekyll and Hyde in the liver. On the one hand, the lipid-laden status of hepatic stellate cells is a hallmark of healthy liver. On the other hand, the opposite is true for lipid-laden hepatocytes—they obstruct liver function.
Martijn R. Molenaar, Louis C. Penning, J. Bernd Helms   +2 more
doaj   +1 more source

Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish

Disease Models & Mechanisms, 2016
Alcoholic liver disease (ALD) results from alcohol overconsumption and is among the leading causes of liver-related morbidity and mortality worldwide. Elevated expression of vascular endothelial growth factor (VEGF) and its receptors has been observed in
Changwen Zhang, Jillian L. Ellis, Chunyue Yin   +2 more
doaj   +1 more source

Adipokines and redox signaling: impact on fatty liver disease. [PDF]

, 2011
Adipokines (adipose tissue cytokines) are polypeptide factors secreted by adipose tissue in a highly regulated manner. The 'classical' adipokines (leptin, adiponectin, and resistin) are expressed only by adipocytes, but other adipokines have been shown ...
Marra, Fabio., Parola, Maurizio, Parola, Maurizio.   +2 more
core   +1 more source

NOX as a Therapeutic Target in Liver Disease

Antioxidants, 2022
The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or NOX) plays a critical role in the inflammatory response and fibrosis in several organs such as the lungs, pancreas, kidney, liver, and heart. In the liver, NOXs contribute,
Deyamira Matuz-Mares, Héctor Vázquez-Meza, María Magdalena Vilchis-Landeros   +2 more
doaj   +1 more source

Hepatic stellate cell heterogeneity and function during the hepatic regenerative response

, 2023
INTRODUCTION: Acetaminophen (APAP) poisoning is the commonest cause of acute liver failure (ALF) in the Western world1 and results in centrilobular hepatic necrosis.
Kitto, Laura
core   +1 more source

N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. [In supplement: 11th International Symposium on the Cells of the Hepatic Sinusoid and their Relation to Other Cells]

, 2004
Apoptosis of hepatic stellate cells (HSC) has previously been shown to occur during spontaneous resolution of experimental liver fibrosis. TIMP-1 has also been shown to have a key role because of its ability to inhibit apoptosis of HSC via matrix ...
Iredale, John P., Julian Waung, Derek Mann, R Christopher Benyon, Collins, Jane, Arthur, Michael J.P., Murphy, Frank, Nagase, Hideaki, Hideaki Nagase, John P Iredale, Mann, Derek, Frank Murphy, Waung, Julian, Jane Collins, Benyon, R. Christopher, Michael JP Arthur   +15 more
core   +1 more source

Human Liver Stem Cell-Derived Extracellular Vesicles Target Hepatic Stellate Cells and Attenuate Their Pro-fibrotic Phenotype

Frontiers in Cell and Developmental Biology, 2021
Liver fibrosis occurs in response to chronic liver injury and is characterized by an excessive deposition of extracellular matrix. Activated hepatic stellate cells are primarily responsible for this process.
Giulia Chiabotto, Giulia Chiabotto, Elena Ceccotti, Elena Ceccotti, Marta Tapparo, Marta Tapparo, Giovanni Camussi, Giovanni Camussi, Stefania Bruno, Stefania Bruno   +9 more
doaj   +1 more source